Targeting copper in cancer therapy: ‘Copper That Cancer’

Metallomics ◽  
2015 ◽  
Vol 7 (11) ◽  
pp. 1459-1476 ◽  
Author(s):  
Delphine Denoyer ◽  
Shashank Masaldan ◽  
Sharon La Fontaine ◽  
Michael A. Cater
Keyword(s):  
Cancer Therapy ◽  
Coordination Compounds ◽  
Copper Coordination

Copper coordination compounds target copper in cancer by diverse mechanisms.

scholarly journals Copper(II) 2,2-Bis(Hydroxymethyl)Propionate Coordination Compounds with Hexamethylenetetramine: From Mononuclear Complex to One-Dimensional Coordination Polymer

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3358
Author(s):  
Sadaf Rauf ◽  
Agata Trzesowska-Kruszynska ◽  
Tomasz Sierański ◽  
Marcin Świątkowski
Keyword(s):  
Coordination Polymer ◽  
Coordination Compounds ◽  
Structural Diversity ◽  
Structural Features ◽  
Mononuclear Complex ◽  
Molar Ratio ◽  
One Dimensional ◽  
1D Coordination Polymer ◽  
Copper Coordination ◽  
Stretching Vibrations

Three new copper coordination compounds derived from 2,2-bis(hydroxymethyl)propionic acid (dmpa) and hexamethylenetetramine (hmta) were obtained and their crystal structures were determined. The stoichiometry of the reagents applied in the syntheses reflects the metal to ligand molar ratio in the formed solid products. Due to the multiple coordination modes of the used ligands, wide structural diversity was achieved among synthesized compounds, i.e., mononuclear [Cu(dmp)2(hmta)2(H2O)] (1), dinuclear [Cu2(dmp)4(hmta)2] (2), and 1D coordination polymer [Cu2(dmp)4(hmta)]n (3). Their supramolecular structures are governed by O—H•••O and O—H•••N hydrogen bonds. The compounds were characterized in terms of absorption (UV-Vis and IR) and thermal properties. The relationships between structural features and properties were discussed in detail. Owing to discrepancies in the coordination mode of a dmp ligand, bidentate chelating in 1, and bidentate bridging in 2 and 3, there is a noticeable change in the position of the bands corresponding to the stretching vibrations of the carboxylate group in the IR spectra. The differences in the structures of the compounds are also reflected in the nature and position of the UV-Vis absorption maxima, which are located at lower wavelengths for 1.

Coordination compounds of biogenic metals as cytotoxic agents for the cancer therapy

2021 ◽  
Vol 90 ◽  
Author(s):  
Dmitry Alexandrovich Guk ◽  
Olga Olegovna Krasnovskaya ◽  
Elena Kimovna Beloglazkina
Keyword(s):  
Cancer Therapy ◽  
Coordination Compounds ◽  
Cytotoxic Agents ◽  
Biogenic Metals

Syntheses and properties of two chiral multidentate carboxylate copper coordination compounds

2012 ◽  
Vol 65 (23) ◽  
pp. 4137-4146 ◽  
Author(s):  
Ying-Hui Yu ◽  
Chang-Yue Ren ◽  
Guang-Feng Hou ◽  
Hantao Ye ◽  
Jin-Sheng Gao
Keyword(s):  
Coordination Compounds ◽  
Copper Coordination

Novel heteronuclear ruthenium–copper coordination compounds as efficient DNA-cleaving agents

2010 ◽  
Vol 46 (20) ◽  
pp. 3568 ◽  
Author(s):  
Stefanie van der Steen ◽  
Paul de Hoog ◽  
Karlijn van der Schilden ◽  
Patrick Gamez ◽  
Marguerite Pitié ◽  
...  
Keyword(s):  
Coordination Compounds ◽  
Dna Cleaving ◽  
Copper Coordination

scholarly journals Encapsulation of antitumor copper coordination compounds into liposomes

2021 ◽  
Vol 1 (Supplement) ◽  
Author(s):  
T. Yakimova ◽  
K. Vlasova ◽  
A. Bubley ◽  
O. Krasnovskaya ◽  
N. Klyachko
Keyword(s):  
Coordination Compounds ◽  
Copper Coordination
Sign in / Sign up

Export Citation Format

Share Document