scholarly journals Bacterial iron–sulfur cluster sensors in mammalian pathogens

Metallomics ◽  
2015 ◽  
Vol 7 (6) ◽  
pp. 943-956 ◽  
Author(s):  
Halie K. Miller ◽  
Victoria Auerbuch
Keyword(s):  
Gene Expression ◽  
Bacterial Pathogenesis ◽  
Environmental Cues ◽  
Iron Sulfur Cluster ◽  
Control Of Gene Expression ◽  
Sulfur Cluster ◽  
Iron Sulfur

We review how iron–sulfur cluster-containing regulators contribute to bacterial pathogenesis through control of gene expression in response to environmental cues.

scholarly journals Iron-sulfur cluster proteins: electron transfer and beyond.

2006 ◽  
Vol 53 (4) ◽  
pp. 685-691 ◽  
Author(s):  
Kamil Brzóska ◽  
Sylwia Meczyńska ◽  
Marcin Kruszewski
Keyword(s):  
Electron Transfer ◽  
Cellular Response ◽  
Iron Sulfur Cluster ◽  
Control Of Gene Expression ◽  
Sulfur Cluster ◽  
Labile Iron Pool ◽  
Cellular Processes ◽  
Iron Sulfur ◽  
Synthesis And Processing ◽  
Iron Pool

Iron-sulfur clusters-containing proteins participate in many cellular processes, including crucial biological events like DNA synthesis and processing of dioxygen. In most iron-sulfur proteins, the clusters function as electron-transfer groups in mediating one-electron redox processes and as such they are integral components of respiratory and photosynthetic electron transfer chains and numerous redox enzymes involved in carbon, oxygen, hydrogen, sulfur and nitrogen metabolism. Recently, novel regulatory and enzymatic functions of these proteins have emerged. Iron-sulfur cluster proteins participate in the control of gene expression, oxygen/nitrogen sensing, control of labile iron pool and DNA damage recognition and repair. Their role in cellular response to oxidative stress and as a source of free iron ions is also discussed.

scholarly journals Sensing mechanisms of iron-sulfur cluster regulatory proteins elucidated using native mass spectrometry

2021 ◽  
Author(s):  
Jason C Crack ◽  
Elizabeth Gray ◽  
Nick Le Brun
Keyword(s):  
Mass Spectrometry ◽  
Native Mass Spectrometry ◽  
Regulatory Proteins ◽  
Environmental Cues ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur ◽  
Sense And Respond

The ability to sense and respond to various key environmental cues is important for the survival and adaptability of many bacteria, including pathogens. The particular sensitivity of iron-sulfur (Fe-S) clusters...

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