1-[(2E)-3-Phenylprop-2-enoyl]-1H-benzimidazoles as anticancer agents: synthesis, crystal structure analysis and binding studies of the most potent anticancer molecule with serum albumin

MedChemComm ◽  
2015 ◽  
Vol 6 (11) ◽  
pp. 1942-1953 ◽  
Author(s):  
Veerendra Kumar A. Kalalbandi ◽  
J. Seetharamappa
Keyword(s):  
Crystal Structure ◽  
Antitumor Activity ◽  
Serum Albumin ◽  
Anticancer Activity ◽  
Anticancer Agents ◽  
Spectral Methods ◽  
Crystal Structure Analysis ◽  
Selectivity Ratio ◽  
Binding Studies ◽  
Mechanism Of Interaction

The anticancer activity of 1H-benzimidazoles was studied against NCI 60 cell panel. Compound 3f showed antitumor activity with good to moderate selectivity ratio. Mechanism of interaction of 3f with protein was studied by spectral methods.

scholarly journals Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate

2018 ◽  
Vol 13 ◽  
pp. 78-82 ◽  
Author(s):  
Akito Kawai ◽  
Keishi Yamasaki ◽  
Taisuke Enokida ◽  
Shuichi Miyamoto ◽  
Masaki Otagiri
Keyword(s):  
Crystal Structure ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Structure Analysis ◽  
Crystal Structure Analysis

scholarly journals Chirality in Anticancer Agents

2021 ◽  
Author(s):  
Jindra Valentová ◽  
Lucia Lintnerová
Keyword(s):  
Biological Activity ◽  
Antitumor Activity ◽  
Nucleic Acids ◽  
Anticancer Activity ◽  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Biological Molecules ◽  
Therapeutic Activity ◽  
Specific Recognition

Many drugs are chiral and their therapeutic activity depends on specific recognition of chiral biomolecules. The biological activity of enantiomers can also differ drastically in terms of toxicity and pharmacokinetics. Chiral natural biological molecules, such as nucleic acids, enzymes are targeted molecules for the development of anticancer drugs. The interest in chiral agents is logically a result of the different interaction with biomolecules leading in the end consequence to improve anticancer activity and maybe to less undesirable effects. This review outlines the effects of chirality on the efficiency of anticancer metal-based agents and potential organic drugs. A variety of up-to-date examples of structurally diverse chiral agents exhibiting different mechanisms in their antitumor activity is presented.

scholarly journals Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin

2001 ◽  
Vol 276 (25) ◽  
pp. 22804-22809 ◽  
Author(s):  
Isabelle Petitpas ◽  
Ananyo A. Bhattacharya ◽  
Sue Twine ◽  
Malcolm East ◽  
Stephen Curry
Keyword(s):  
Crystal Structure ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Structure Analysis ◽  
Crystal Structure Analysis

Crystal Structure Analysis of Cu-Zr Alloys by Convergent Beam Diffraction

1981 ◽  
Vol 39 ◽  
pp. 354-355
Author(s):  
A. F. Marshall ◽  
J. W. Steeds ◽  
D. Bouchet ◽  
S. L. Shinde ◽  
R. G. Walmsley
Keyword(s):  
Crystal Structure ◽  
Point Group ◽  
Intermetallic Phase ◽  
Three Dimensional ◽  
Crystal Structure Analysis ◽  
Ion Milling ◽  
Composition And Structure ◽  
Unit Cells ◽  
Sputter Deposited ◽  
Convergent Beam

Convergent beam electron diffraction is a powerful technique for determining the crystal structure of a material in TEM. In this paper we have applied it to the study of the intermetallic phases in the Cu-rich end of the Cu-Zr system. These phases are highly ordered. Their composition and structure has been previously studied by microprobe and x-ray diffraction with sometimes conflicting results.The crystalline phases were obtained by annealing amorphous sputter-deposited Cu-Zr. Specimens were thinned for TEM by ion milling and observed in a Philips EM 400. Due to the large unit cells involved, a small convergence angle of diffraction was used; however, the three-dimensional lattice and symmetry information of convergent beam microdiffraction patterns is still present. The results are as follows:1) 21 at% Zr in Cu: annealed at 500°C for 5 hours. An intermetallic phase, Cu3.6Zr (21.7% Zr), space group P6/m has been proposed near this composition (2). The major phase of our annealed material was hexagonal with a point group determined as 6/m.

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