Comparative proteomic profiling of Hodgkin lymphoma cell lines

2016 ◽  
Vol 12 (1) ◽  
pp. 219-232 ◽  
Author(s):  
D. Vergara ◽  
P. Simeone ◽  
S. De Matteis ◽  
S. Carloni ◽  
P. Lanuti ◽  
...  
Keyword(s):  
Protein Expression ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lines ◽  
Expression Profiles ◽  
Lymphoma Cell ◽  
Classical Hodgkin Lymphoma ◽  
Proteomic Profiling ◽  
Hodgkin Lymphoma Cell ◽  
Protein Expression Profiles

Classical Hodgkin lymphoma models of T- and B-cell derivation show significant differences in their protein expression profiles.

scholarly journals PO-379 Novel tumour specific miRNA expressed in classical hodgkin lymphoma cell lines

2018 ◽  
Author(s):  
A Ustaszewski ◽  
J Paczkowska ◽  
J Janiszewska ◽  
S Hartmann ◽  
J Bein ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Cell Lines ◽  
Lymphoma Cell ◽  
Classical Hodgkin Lymphoma ◽  
Hodgkin Lymphoma Cell

Recurrent genetic defects in classical Hodgkin lymphoma cell lines

2016 ◽  
Vol 57 (12) ◽  
pp. 2890-2900 ◽  
Author(s):  
S. David Hudnall ◽  
Hailong Meng ◽  
Larissa Lozovatsky ◽  
Peining Li ◽  
Matthew Strout ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Cell Lines ◽  
Lymphoma Cell ◽  
Genetic Defects ◽  
Classical Hodgkin Lymphoma ◽  
Hodgkin Lymphoma Cell

scholarly journals PD‑1 blockade enhances cytokine‑induced killer cell‑mediated cytotoxicity in B‑cell non‑Hodgkin lymphoma cell lines

2021 ◽  
Vol 22 (2) ◽  
Author(s):  
Yutao Li ◽  
Amit Sharma ◽  
Maurits Bloemendal ◽  
Roland Schmidt‑Wolf ◽  
Miroslaw Kornek ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lines ◽  
Killer Cell ◽  
Lymphoma Cell ◽  
Non Hodgkin Lymphoma ◽  
Hodgkin Lymphoma Cell

Patterned CpG Methylation of Silenced B Cell Gene Promoters in Classical Hodgkin Lymphoma-derived and Primary Effusion Lymphoma Cell Lines

2005 ◽  
Vol 350 (4) ◽  
pp. 631-640 ◽  
Author(s):  
Jeanette R. Doerr ◽  
Cindy S. Malone ◽  
Francesca M. Fike ◽  
Melinda S. Gordon ◽  
Shahe V. Soghomonian ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lines ◽  
Primary Effusion Lymphoma ◽  
Cpg Methylation ◽  
Lymphoma Cell ◽  
Gene Promoters ◽  
Classical Hodgkin Lymphoma ◽  
Primary Effusion Lymphoma Cell ◽  
Cell Gene

scholarly journals Deregulated miRNAs Contribute to Silencing of B-Cell Specific Transcription Factors and Activation of NF-κB in Classical Hodgkin Lymphoma

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3131
Author(s):  
Julia Paczkowska ◽  
Joanna Janiszewska ◽  
Adam Ustaszewski ◽  
Julia Bein ◽  
Marcin Skalski ◽  
...  
Keyword(s):  
Transcription Factors ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lines ◽  
Target Genes ◽  
Cell Phenotype ◽  
Classical Hodgkin Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
Hodgkin Lymphoma Cell ◽  
Mirna Expression Profiling

A hallmark of classical Hodgkin lymphoma (cHL) is the attenuation of B-cell transcription factors leading to global transcriptional reprogramming. The role of miRNAs (microRNAs) involved in this process is poorly studied. Therefore, we performed global miRNA expression profiling using RNA-seq on commonly used cHL cell lines, non-Hodgkin lymphoma cell lines and sorted normal CD77+ germinal centre B-cells as controls and characterized the cHL miRNome (microRNome). Among the 298 miRNAs expressed in cHL, 56 were significantly overexpressed and 23 downregulated (p < 0.05) compared to the controls. Moreover, we identified five miRNAs (hsa-miR-9-5p, hsa-miR-24-3p, hsa-miR-196a-5p, hsa-miR-21-5p, hsa-miR-155-5p) as especially important in the pathogenesis of this lymphoma. Target genes of the overexpressed miRNAs in cHL were significantly enriched (p < 0.05) in gene ontologies related to transcription factor activity. Therefore, we further focused on selected interactions with the SPI1 and ELF1 transcription factors attenuated in cHL and the NF-ĸB inhibitor TNFAIP3. We confirmed the interactions between hsa-miR-27a-5p:SPI1, hsa-miR-330-3p:ELF-1, hsa-miR-450b-5p:ELF-1 and hsa-miR-23a-3p:TNFAIP3, which suggest that overexpression of these miRNAs contributes to silencing of the respective genes. Moreover, by analyzing microdissected HRS cells, we demonstrated that these miRNAs are also overexpressed in primary tumor cells. Therefore, these miRNAs play a role in silencing the B-cell phenotype in cHL.

BAY 43‐9006/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines

2011 ◽  
Vol 155 (3) ◽  
pp. 398-402 ◽  
Author(s):  
Katrin Ullrich ◽  
Kathrin D. Wurster ◽  
Björn Lamprecht ◽  
Karl Köchert ◽  
Andreas Engert ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Cell Lines ◽  
Lymphoma Cell ◽  
Classical Hodgkin Lymphoma ◽  
Hodgkin Lymphoma Cell
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