scholarly journals A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

2016 ◽  
Vol 12 (3) ◽  
pp. 839-849 ◽  
Author(s):  
Z. Lin ◽  
K. S. Bishop ◽  
H. Sutherland ◽  
G. Marlow ◽  
P. Murray ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Chronic Inflammation ◽  
Hdac Inhibitor ◽  
Cholesterol Biosynthesis ◽  
Prostate Cancer Cells ◽  
Resolution Of Inflammation ◽  
Expression Pathways

Chronic inflammation can lead to the development of cancers and resolution of inflammation is an ongoing challenge.

Abstract 309: Effect of histone deacetylase (HDAC) inhibitor on gene expression in MDM2 transfected prostate cancer cells

2017 ◽  
Author(s):  
Thiagarajan Venkatesan ◽  
Ali Alaseem ◽  
Khalid Alhazzani ◽  
Thanigaivelan Kanagasabai ◽  
Appu Rathinavelu
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Hdac Inhibitor ◽  
Prostate Cancer Cells

scholarly journals Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression

2017 ◽  
Vol 46 (7) ◽  
pp. 1495-1504 ◽  
Author(s):  
Neda Shajari ◽  
Sadaf Davudian ◽  
Tohid Kazemi ◽  
Behzad Mansoori ◽  
Shima Salehi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Related Gene ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

scholarly journals 1100: Gene Expression Profiles of Doxazosin-Treated LNCaP Prostate Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 290-290
Author(s):  
José M. Arencibia ◽  
Mónica Del Río ◽  
Ana Bonnin ◽  
Mónica López-Barahona
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostate Cancer Cells

C/EBPβ regulates metastatic gene expression and confers TNF-α resistance to prostate cancer cells

The Prostate ◽  
2009 ◽  
Vol 69 (13) ◽  
pp. 1435-1447 ◽  
Author(s):  
Myoung H. Kim ◽  
Alena Z. Minton ◽  
Vikas Agrawal
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Tnf Α

scholarly journals Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines

2016 ◽  
Vol 94 (1) ◽  
pp. 71-81 ◽  
Author(s):  
Ata Abbas ◽  
J. Adam Hall ◽  
William L. Patterson ◽  
Emily Ho ◽  
Anna Hsu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Prostate Cancer Cell ◽  
Histone H3 ◽  
Htert Promoter ◽  
Prostate Cancer Cells ◽  
Inhibitor Activity ◽  
Prostate Cancer Cell Lines

Epidemiologic studies have revealed that diets rich in sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables, are associated with a marked decrease in prostate cancer incidence. The chemo-preventive role of SFN is associated with its histone de-acetylase inhibitor activity. However, the effect of SFN on chromatin composition and dynamic folding, especially in relation to HDAC inhibitor activity, remains poorly understood. In this study, we found that SFN can inhibit the expression and activity of human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, in 2 prostate cancer cell lines. This decrease in gene expression is correlated with SFN-induced changes in chromatin structure and composition. The SFN-mediated changes in levels of histone post-translational modifications, more specifically acetylation of histone H3 lysine 18 and di-methylation of histone H3 lysine 4, 2 modifications linked with high risk of prostate cancer recurrence, were associated with regulatory elements within the hTERT promoter region. Chromatin condensation may also play a role in SFN-mediated hTERT repression, since expression and recruitment of MeCP2, a known chromatin compactor, were altered in SFN treated prostate cancer cells. Chromatin immuno-precipitation (ChIP) of MeCP2 showed enrichment over regions of the hTERT promoter with increased nucleosome density. These combined results strongly support a role for SFN in the mediation of epigenetic events leading to the repression of hTERT in prostate cancer cells. This ability of SFN to modify chromatin composition and structure associated with target gene expression provides a new model by which dietary phytochemicals may exert their chemoprevention activity.

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