Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework

2015 ◽  
Vol 11 (11) ◽  
pp. 3011-3021 ◽  
Author(s):  
Yuan Wang ◽  
Zihu Guo ◽  
Xuetong Chen ◽  
Wenjuan Zhang ◽  
Aiping Lu ◽  
...  
Keyword(s):  
Cell Survival ◽  
Cell Fate ◽  
Mammalian Cells ◽  
Regulatory Process ◽  
Systems Pharmacology ◽  
Multi Scale ◽  
Scale Modeling ◽  
Multi Scale Modeling ◽  
P53 Network

The determination of cell fate is a key regulatory process for the development of complex organisms that are controlled by distinct genes in mammalian cells.

Crack Growth Resistance of CMC Attachment Element and Turbine Joint in Aircraft Engines

2017 ◽  
Author(s):  
Frank Abdi ◽  
Saber DorMohammadi ◽  
Jalees Ahmad ◽  
Cody Godines ◽  
Gregory N. Morscher ◽  
...  
Keyword(s):  
Fracture Energy ◽  
Crack Growth ◽  
Building Block ◽  
Structural Integrity ◽  
Crack Growth Resistance ◽  
Multi Scale ◽  
Scale Modeling ◽  
Multi Scale Modeling ◽  
Service Loading

A Durability and Damage Tolerance (D&DT) analysis of an S200 Nicalon/SiNC CVI SiC/SiC attachment joint was conducted to determine the CMC components material structural integrity during service loading. A building block validation strategy is proposed that includes: (i) Room, and High Temperature (RT/HT) testing with AE (Acoustic Emission) and ER (Electrical Resistivity) strategies; (ii) Advanced multi-scale modeling; (iii) Interpretation test/model; and (iv) ASTM draft submittal of simplified beam equation supported by FEM/test compliance and round robin exercise. The following building block calibration, verification, validation, and accreditation strategy were performed: 1) Material characterization analysis to determine the damage evolution under uniaxial tensile loads and compared with test; 2) Crack Growth Resistance (CGR) analysis and test of wedge loaded DCB (Double Cantilever Beam) to determine the crack growth length, zig-zag pattern, fracture, shift in failure mechanisms and derivation of fracture energy vs. crack length simple formulation at RT; 3) Joint loading multi scale modeling and comparison with observed test load displacement curve, and determination of fracture energy; and 4) blade structural integrity and response under service loading using Multi-Scale Progressive Failure Analysis (MS-PFA) and determination of contributing damage and delamination types and their locations. FE based MS-PFA of the material and structure studied addressed the critical damage events (damage initiation, damage propagation, fracture initiation, and fracture propagation) as the components were being loaded. All dehomogenized multi scale methods CMC parameters were implemented in the material and structural modeling strategy, such as crack density effects and architecture (2D, 3D orthogonal, and mixed) interphase thickness, and interfacial shear strength. Many parameters that contribute to specimen failure including interface coating thickness, mixed mode failure evolution, interlaminar defects, delamination damage, crack bridging, and fiber fracture were all studied in detail in this work. Several FE-based multi-scale modeling techniques were investigated: a) MS-PFA; b) Virtual Crack Closure Technique (VCCT); and c) integrated damage and fracture evolution methodology using combined MS-PFA and VCCT.

Multi-Scale Modeling of Cementitious Materials (Briefing Chart)

2014 ◽  
Author(s):  
M. M. Shahzamanian ◽  
T. Tadepalli ◽  
A. M. Rajendran ◽  
W. D. Hodo ◽  
R. Mohan ◽  
...  
Keyword(s):  
Cementitious Materials ◽  
Multi Scale ◽  
Scale Modeling ◽  
Multi Scale Modeling

Multi-Scale Modeling of Neural Structure in X-Ray Imagery

2021 ◽  
Author(s):  
Aishwarya Balwani ◽  
Joseph Miano ◽  
Ran Liu ◽  
Lindsey Kitchell ◽  
Judy A. Prasad ◽  
...  
Keyword(s):  
Neural Structure ◽  
X Ray ◽  
Multi Scale ◽  
Scale Modeling ◽  
Multi Scale Modeling

Multi-scale modeling and experimental study of fatigue of plain-woven SiC/SiC composites

2021 ◽  
pp. 106725
Author(s):  
Hongnian Dong ◽  
Xiguang Gao ◽  
Sheng Zhang ◽  
Guoqiang Yu ◽  
Yingdong Song ◽  
...  
Keyword(s):  
Experimental Study ◽  
Multi Scale ◽  
Scale Modeling ◽  
Multi Scale Modeling ◽  
Sic Composites

A novel synergistic multi-scale modeling framework to predict micro- and meso-scale damage behaviors of 2D triaxially braided composite

2021 ◽  
pp. 105678952110339
Author(s):  
Hongyong Jiang ◽  
Yiru Ren ◽  
Qiduo Jin
Keyword(s):  
Compressive Load ◽  
Scale Model ◽  
Modeling Framework ◽  
Braided Composite ◽  
Multi Scale ◽  
Scale Modeling ◽  
Bridge Model ◽  
Multi Scale Modeling ◽  
Transverse Damage ◽  
Meso Scale

A novel synergistic multi-scale modeling framework with a coupling of micro- and meso-scale is proposed to predict damage behaviors of 2D-triaxially braided composite (2DTBC). Based on the Bridge model, the internal stress and micro damage of constituent materials are respectively coupled with the stress and damage of tow. The initial effective elastic properties of tow (IEEP) used as the predefined data are estimated by micro-mechanics models. Due to in-situ effects, stress concentration factor (SCF) is considered in the micro matrix, exhibiting progressive damage accumulation. Comparisons of IEEP and strengths between the Bridge and Chamis’ theory are conducted to validate the values of IEEP and SCF. Based on the representative volume element (RVE), the macro properties and damage modes of 2DTBC are predicted to be consistent with available experiments and meso-scale simulation. Both axial and transverse damage mechanisms of 2DTBC under tensile or compressive load are revealed. Micro fiber and matrix damage accumulations have significant effects on the meso-scale axial and transverse damage of tows due to multi-scale coupling effects. Different from existing meso-/multi-scale models, the proposed multi-scale model can capture a crucial phenomenon that the transverse damage of tow is vulnerable to micro fiber fracture. The proposed multi-scale framework provides a robust tool for future systematic studies on constituent materials level to larger-scale aeronautical materials.

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