Ultratrace analysis of krypton isotopes by resonant ionization spectroscopy-time of flight mass spectrometry (RIS-TOF)

2016 ◽  
Vol 31 (4) ◽  
pp. 994-1001 ◽  
Author(s):  
Eric Gilabert ◽  
Bernard Lavielle ◽  
Bertrand Thomas ◽  
Sylvain Topin ◽  
Fabien Pointurier ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
High Sensitivity ◽  
Isotope Ratios ◽  
Ultratrace Analysis ◽  
Resonant Ionization ◽  
Flight Mass Spectrometry

A new RIS-TOF instrument, called FAKIR (Facility for Analyzing Krypton Isotope Ratios), has been developed at CENBG in order to measure Kr isotope ratios with an extremely high sensitivity.

scholarly journals High mass resolution MALDI-TOF MS for profiling biomolecules in mixtures

2018 ◽  
Author(s):  
Wenfa Ng
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
High Sensitivity ◽  
Mass Resolution ◽  
High Mass ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Flight Mass Spectrometry ◽  
High Mass Resolution ◽  
Tof Ms

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules by mass spectrometry without inducing fragmentation. Doing so generates an ensemble of ionized intact biomolecules able to be profiled by high sensitivity time-of-flight detector for accurate determination of each biomolecule mass, and thus, identity. Specifically, in time-of-flight detection, high mass resolution determination would require high sensitivity in detecting small differences in time of arrival of biomolecule ions to the detector. While current time-of-flight mass spectrometry provides high mass resolution, greater mass resolution is needed for discriminating different biomolecules in a mixture, where mass differences between biomolecules could be at the sub-Dalton level. With the ability to reliably detect biomolecules with sub-Dalton mass resolution, mass spectrometry with time-of-flight detector such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) could find use in identifying the compendium of biomolecules present in a mixture without tedious and time-consuming separation. The larger question would subsequently be coupling sample preparation needs with the conditions conducive for MALDI-TOF MS analysis. Overall, high mass resolution mass spectrometry techniques for profiling biomolecules would find use as an enabling tool in many areas of analytical science and biological sciences such as proteomics and metabolomics.

Quantitation of Metal Isotope Ratios by Laser Desorption Time-of-Flight Mass Spectrometry

1995 ◽  
Vol 67 (24) ◽  
pp. 4557-4564 ◽  
Author(s):  
Iphigenia L. Koumenis ◽  
Marvin L. Vestal ◽  
Alfred L. Yergey ◽  
Steven. Abrams ◽  
Stanley N. Deming ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
Laser Desorption ◽  
Isotope Ratios ◽  
Flight Mass Spectrometry ◽  
Desorption Time

scholarly journals High mass resolution MALDI-TOF MS for profiling biomolecules in mixtures

2018 ◽  
Author(s):  
Wenfa Ng
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
High Sensitivity ◽  
Mass Resolution ◽  
High Mass ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Flight Mass Spectrometry ◽  
High Mass Resolution ◽  
Tof Ms

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules by mass spectrometry without inducing fragmentation. Doing so generates an ensemble of ionized intact biomolecules able to be profiled by high sensitivity time-of-flight detector for accurate determination of each biomolecule mass, and thus, identity. Specifically, in time-of-flight detection, high mass resolution determination would require high sensitivity in detecting small differences in time of arrival of biomolecule ions to the detector. While current time-of-flight mass spectrometry provides high mass resolution, greater mass resolution is needed for discriminating different biomolecules in a mixture, where mass differences between biomolecules could be at the sub-Dalton level. With the ability to reliably detect biomolecules with sub-Dalton mass resolution, mass spectrometry with time-of-flight detector such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) could find use in identifying the compendium of biomolecules present in a mixture without tedious and time-consuming separation. The larger question would subsequently be coupling sample preparation needs with the conditions conducive for MALDI-TOF MS analysis. Overall, high mass resolution mass spectrometry techniques for profiling biomolecules would find use as an enabling tool in many areas of analytical science and biological sciences such as proteomics and metabolomics.

Sensing of Oligopeptides Using Alternatively-Deposited Gold Nanorods for Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

2012 ◽  
Vol 1418 ◽  
Author(s):  
Masanori Fujii ◽  
Naotoshi Nakashima ◽  
Yasuro Niidome
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanorods ◽  
Time Of Flight ◽  
High Sensitivity ◽  
Laser Desorption ◽  
Laser Desorption Ionization ◽  
Ionization Time ◽  
Desorption Ionization ◽  
Flight Mass Spectrometry ◽  
Saldi Ms

ABSTRACTGold nanorods (NRs) were fixed on an ITO plate and used for the Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SALDI-MS) of oligopeptides (angiotensin I). The SALDI-MS measurements had a high sensitivity to the angiotensin on the ITO plate on which isolated NRs were deposited. Angiotensin molecules in a very diluted solution (1 × 10-11 M) could be detected at m/z = 1297 with a good signal/noise ratio (S/N = 18). In contrast, alternatively deposited NR an ITO plate, which present broad surface plasmon bands, was found to be inactive for SALDI measurements.

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