scholarly journals Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

2015 ◽  
Vol 7 (10) ◽  
pp. 1120-1134 ◽  
Author(s):  
I. Acerbi ◽  
L. Cassereau ◽  
I. Dean ◽  
Q. Shi ◽  
A. Au ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Immune Cell ◽  
Cancer Invasion ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Human Breast ◽  
Breast Cancer Invasion

The nude mouse as anin vivo model for human breast cancer invasion and metastasis

1993 ◽  
Vol 24 (3) ◽  
pp. 257-264 ◽  
Author(s):  
Nils Brünner ◽  
Birgitte Boysen ◽  
John Rømer ◽  
Mogens Spang-Thomsen
Keyword(s):  
Breast Cancer ◽  
Nude Mouse ◽  
Human Breast Cancer ◽  
Cancer Invasion ◽  
Human Breast ◽  
Invasion And Metastasis ◽  
Breast Cancer Invasion

scholarly journals Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN

2014 ◽  
Vol 7 (2) ◽  
pp. 143-153 ◽  
Author(s):  
Kerstin Menck ◽  
Christian Scharf ◽  
Annalen Bleckmann ◽  
Lydia Dyck ◽  
Ulrike Rost ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Cancer Invasion ◽  
Human Breast ◽  
Breast Cancer Invasion

scholarly journals Correlation Between 18F-FDG Uptake and Immune Cell Infiltration in Metastatic Brain Lesions

2021 ◽  
Vol 11 ◽  
Author(s):  
Young-Sil An ◽  
Se-Hyuk Kim ◽  
Tae Hoon Roh ◽  
So Hyun Park ◽  
Tae-Gyu Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune Cells ◽  
Immune Cell ◽  
Standardized Uptake Value ◽  
Brain Lesions ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Ki 67 ◽  
Glucose Transporter 1 ◽  
Fdg Uptake

BackgroundThe purpose of this study was to investigate the correlation between 18F-fluorodeoxyglucose (FDG) uptake and infiltrating immune cells in metastatic brain lesions.MethodsThis retrospective study included 34 patients with metastatic brain lesions who underwent brain 18F-FDG positron emission tomography (PET)/computed tomography (CT) followed by surgery. 18F-FDG uptake ratio was calculated by dividing the standardized uptake value (SUV) of the metastatic brain lesion by the contralateral normal white matter uptake value. We investigated the clinicopathological characteristics of the patients and analyzed the correlation between 18F-FDG uptake and infiltration of various immune cells. In addition, we evaluated immune-expression levels of glucose transporter 1 (GLUT1), hexokinase 2 (HK2), and Ki-67 in metastatic brain lesions.ResultsThe degree of 18F-FDG uptake of metastatic brain lesions was not significantly correlated with clinical parameters. There was no significant relationship between the 18F-FDG uptake and degree of immune cell infiltration in brain metastasis. Furthermore, other markers, such as GLUT1, HK2, and Ki-67, were not correlated with degree of 18F-FDG uptake. In metastatic brain lesions that originated from breast cancer, a higher degree of 18F-FDG uptake was observed in those with high expression of CD68.ConclusionsIn metastatic brain lesions, the degree of 18F-FDG uptake was not significantly associated with infiltration of immune cells. The 18F-FDG uptake of metastatic brain lesions from breast cancer, however, might be associated with macrophage activity.

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