Copper(i)/phosphine-catalyzed tandem carboxylation/annulation of terminal alkynes under ambient pressure of CO2: one-pot access to 3a-hydroxyisoxazolo[3,2-a]isoindol-8(3aH)-ones

2015 ◽  
Vol 17 (7) ◽  
pp. 4061-4067 ◽  
Author(s):  
Jia-Ning Xie ◽  
Bing Yu ◽  
Chun-Xiang Guo ◽  
Liang-Nian He
Keyword(s):  
Catalytic System ◽  
Ambient Pressure ◽  
Terminal Alkynes ◽  
One Pot ◽  
Simultaneous Formation ◽  
Stepwise Manner

A tandem carboxylation/annulation sequence promoted by a copper(i)/phosphine catalytic system was developed with simultaneous formation of four novel bonds i.e. two C–C bonds and two C–O bonds in a one-pot stepwise manner.

Synergetic Catalysis for One‐pot Bis‐alkoxycarbonylation of Terminal Alkynes over Pd/Xantphos−Al(OTf) 3 Bi‐functional Catalytic System

ChemCatChem ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1376-1384
Author(s):  
Wen‐Di Guo ◽  
Lei Liu ◽  
Shu‐Qing Yang ◽  
Xiao‐Chao Chen ◽  
Yong Lu ◽  
...  
Keyword(s):  
Catalytic System ◽  
Terminal Alkynes ◽  
One Pot

scholarly journals Silver-catalyzed one-pot synthesis of benzyl 2-alkynoates under ambient pressure of CO2 and ligand-free conditions

Tetrahedron ◽  
2017 ◽  
Vol 73 (7) ◽  
pp. 900-906 ◽  
Author(s):  
Fang-Jie Guo ◽  
Zhi-Zhi Zhang ◽  
Jing-Yun Wang ◽  
Jing Sun ◽  
Xiang-Chen Fang ◽  
...  
Keyword(s):  
Ambient Pressure ◽  
One Pot ◽  
One Pot Synthesis ◽  
Ligand Free

Indium-Catalyzed Direct Conversion of Lactones into Thiolactones and Selenolactones in the Presence of Elemental Sulfur and Selenium

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 565-574 ◽  
Author(s):  
Norio Sakai ◽  
Shuhei Horikawa ◽  
Yohei Ogiwara
Keyword(s):  
Catalytic System ◽  
Elemental Sulfur ◽  
Direct Conversion ◽  
The Novel ◽  
One Pot

The direct conversion of lactones into thiolactones with elemental sulfur (S8) catalyzed by InCl3/PhSiH3 in a one-pot reaction is described. This catalytic system was successfully applied to the novel preparation of selenolactones from lactones and selenium.

scholarly journals Bis-NHC–Ag/Pd(OAc)2 Catalytic System Catalyzed Transfer Hydrogenation Reaction

Catalysts ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 8
Author(s):  
Hui-Ju Chen ◽  
Chien-Cheng Chiu ◽  
Tsui Wang ◽  
Dong-Sheng Lee ◽  
Ta-Jung Lu
Keyword(s):  
Functional Groups ◽  
Catalytic System ◽  
High Efficiency ◽  
Aqueous Media ◽  
Hydrogenation Reaction ◽  
Transfer Hydrogenation ◽  
Terminal Alkynes ◽  
Wide Range ◽  
Transfer Hydrogenation Reaction

The bis-NHC–Ag/Pd(OAc)2 catalytic system (NHC = N-heterocyclic carbene), a combination of bis-NHC–Ag complex and Pd(OAc)2, was found to be a smart catalyst in the Pd-catalyzed transfer hydrogenation of various functionalized arenes and internal/terminal alkynes. The catalytic system demonstrated high efficiency for the reduction of a wide range of various functional groups such as carbonyls, alkynes, olefins, and nitro groups in good to excellent yields and high chemoselectivity for the reduction of functional groups. In addition, the protocol was successfully exploited to stereoselectivity for the transformation of alkynes to alkenes in aqueous media under air. This methodology successfully provided an alternative useful protocol for reducing various functional groups and a simple operational protocol for transfer hydrogenation.

One-Pot Synthesis of Symmetrical and Asymmetrical 3-Amino Diynes via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes

2021 ◽  
Author(s):  
Changyuan Zhang ◽  
Huosheng Guo ◽  
Lulu Chen ◽  
Jiantao Zhang ◽  
Mengping Guo ◽  
...  
Keyword(s):  
Terminal Alkynes ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines

2011 ◽  
Vol 7 ◽  
pp. 338-345 ◽  
Author(s):  
Dhilli Rao Gorja ◽  
K Shiva Kumar ◽  
K Mukkanti ◽  
Manojit Pal
Keyword(s):  
Cytotoxic Activity ◽  
Catalytic System ◽  
High Selectivity ◽  
Bond Formation ◽  
Terminal Alkynes ◽  
Ether Bond ◽  
Pharmacological Evaluation

The Pd/C–CuI–PPh3 catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the chloro compounds and methanol. A variety of novel 4-alkynylthieno[2,3- d]pyrimidines were prepared via alkynylation of 4-chlorothieno[2,3-d]pyrimidines in good to excellent yields. Some of the compounds synthesized were tested for cytotoxic activity in vitro.

scholarly journals Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation

2017 ◽  
Vol 67 (3) ◽  
pp. 309-324 ◽  
Author(s):  
Nadjet Rezki ◽  
Mohamed Reda Aouad
Keyword(s):  
Antimicrobial Activity ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Terminal Alkynes ◽  
One Pot ◽  
Alkyl Aryl ◽  
Antimicrobial Evaluation ◽  
Ultrasound Assisted ◽  
Click Synthesis

AbstractThe present study describes an efficient and ecofriendly, ultrasound, one-pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3-triazoles tethered with fluorinated 1,2,4-triazole-benzothiazole molecular conjugates. It involved three-component condensation of the appropriate bromoacetamide benzothiazole, sodium azide and 4-alkyl/aryl-5-(2-fluorophenyl)-3-(prop-2-ynylthio)-1,2,4-triazoles4a-ethrough a Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction. This approach involvesin situgeneration of azidoacetamide benzothiazole, followed by condensation with terminal alkynes in the presence of CuSO4/Na-ascorbate in aqueous DMSO under both conventional and ultrasound conditions. Some of the designed 1,2,3-triazole conjugates6a-owere recognized for their antimicrobial activity against some bacterial and fungal pathogenic strains.

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