Cordyceps militaris fruit body extract ameliorates membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway

2016 ◽  
Vol 7 (4) ◽  
pp. 2006-2015 ◽  
Author(s):  
Jingjing Song ◽  
Yingwu Wang ◽  
Chungang Liu ◽  
Yan Huang ◽  
Liying He ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fruit Body ◽  
Membranous Glomerulonephritis ◽  
Cordyceps Militaris ◽  
Adult Patients ◽  
Renal Inflammation ◽  
Nephritic Syndrome ◽  
Body Extract ◽  
Common Pathogenesis

Membranous glomerulonephritis (MGN) is a common pathogenesis of nephritic syndrome in adult patients.

scholarly journals Studies on the Antifatigue Activities ofCordyceps militarisFruit Body Extract in Mouse Model

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Jingjing Song ◽  
Yingwu Wang ◽  
Meiyu Teng ◽  
Guangsheng Cai ◽  
Hongkai Xu ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mouse Model ◽  
Mammalian Target Of Rapamycin ◽  
Fruit Body ◽  
Lactic Dehydrogenase ◽  
Cordyceps Militaris ◽  
Body Extract ◽  
Serum Hormone ◽  
Swimming Test ◽  
Amp Activated Protein Kinase

Cordyceps militarishas been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities. Our study aims to investigate the effect ofCordyceps militarisfruit body extract (CM) on antifatigue in mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test. Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. Further data suggests that CM-induced fatigue recovery is mainly through activating 5′-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect. Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

Heat and light stresses affect metabolite production in the fruit body of the medicinal mushroom Cordyceps militaris

2018 ◽  
Vol 102 (10) ◽  
pp. 4523-4533 ◽  
Author(s):  
Zhang Jiaojiao ◽  
Wang Fen ◽  
Liu Kuanbo ◽  
Liu Qing ◽  
Yang Ying ◽  
...  
Keyword(s):  
Fruit Body ◽  
Cordyceps Militaris ◽  
Medicinal Mushroom ◽  
Metabolite Production

scholarly journals Lanostane Triterpenes from Gloeophyllum odoratum and Their Anti-Influenza Effects

Planta Medica ◽  
2018 ◽  
Vol 85 (03) ◽  
pp. 195-202 ◽  
Author(s):  
Ulrike Grienke ◽  
Julia Zwirchmayr ◽  
Ursula Peintner ◽  
Ernst Urban ◽  
Martin Zehl ◽  
...  
Keyword(s):  
Fruit Body ◽  
Ionization Mass ◽  
Body Extract ◽  
H1n1 Strain ◽  
Ic50 Values ◽  
H3n2 Influenza ◽  
Work Up ◽  
First Time ◽  
H3n2 Influenza Virus

AbstractIn an in vitro screening for anti-influenza agents from European polypores, the fruit body extract of Gloeophyllum odoratum dose-dependently inhibited the cytopathic effect of the H3N2 influenza virus A/Hong Kong/68 (HK/68) in Madin Darby canine kidney cells with a 50% inhibitory concentration (IC50) of 15 µg/mL, a noncytotoxic concentration. After a chromatographic work-up, eight lanostane triterpenes (1–8) were isolated and their structures were elucidated based on high-resolution electrospray ionization mass spectrometry analyses, and one- and two-dimensional nuclear magnetic resonance experiments. Constituents 1 (gloeophyllin K) and 2 (gloeophyllin L) are reported here for the first time, and compounds 5, 7, and 8 have not been described for the investigated fungal material so far. The highest activity was determined for trametenolic acid B (3) against HK/68 and the 2009 pandemic H1N1 strain A/Jena/8178/09 with IC50 values of 14 and 11 µM, respectively. In a plaque reduction assay, this compound was able to bind to cell-free viruses and to neutralize their infectivity.

scholarly journals Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice

2020 ◽  
Vol 43 (2) ◽  
pp. 175-180
Author(s):  
Zeba Farooqui ◽  
Razia Sultana Mohammad ◽  
Mustafa F. Lokhandwala ◽  
Anees Ahmad Banday
Keyword(s):  
Oxidative Stress ◽  
Renal Inflammation

Which comes first: Renal inflammation or oxidative stress in spontaneously hypertensive rats?

2007 ◽  
Vol 41 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Subrata K. Biswas ◽  
Jose B. Lopes De Faria ◽  
Subrata K. Biswas ◽  
Jose B. Lopes De Faria
Keyword(s):  
Oxidative Stress ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Renal Inflammation ◽  
Spontaneously Hypertensive
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