Tenuigenin exhibits anti-inflammatory activity via inhibiting MAPK and NF-κB and inducing Nrf2/HO-1 signaling in macrophages

2016 ◽  
Vol 7 (1) ◽  
pp. 355-363 ◽  
Author(s):  
Hongming Lv ◽  
Wenzhi Ren ◽  
Yuwei Zheng ◽  
Lidong Wang ◽  
Gejin Lu ◽  
...  
Keyword(s):  
Chinese Herb ◽  
Inflammatory Activity ◽  
Pharmacological Activities ◽  
Polygala Tenuifolia ◽  
Anti Inflammatory ◽  
Anti Inflammation ◽  
Biological And Pharmacological Activities

Tenuigenin (TNG), isolated from the root of the Chinese herb Polygala tenuifolia, possesses various biological and pharmacological activities, including anti-oxidation and anti-inflammation activities.

scholarly journals SYNTHESIS NEW POTENTIAL ANTI-INFLAMMATORY AGENT SODIUM SALT OF PENTAGAMAVUNON-0

2010 ◽  
Vol 4 (3) ◽  
pp. 180-185
Author(s):  
Enade Perdana Istyastono ◽  
Rr. Sri Untari Siwi S.M.P ◽  
Andreas Asdi Utama ◽  
Supardjan A.M
Keyword(s):  
Inflammatory Activity ◽  
Physiological Changes ◽  
Solubility In Water ◽  
Curcumin Analogues ◽  
Inflammatory Agent ◽  
Curcumin Derivatives ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Living Tissues ◽  
Anti Inflammation

Inflammation is the response of living tissues to injury. The process affects physiological changes such as erythema, edema, asthma and fever. Non-steroid Anti-inflammatory Drugs (NSAIDs) have been developed since they could inhibit inflammation process because of its ability to inhibit biosynthesis of prostaglandin, one of inflammation mediators, through inhibition of cyclooxigenase (COX) enzymes. Molecules, which have been reported having anti-inflammatory activity, for example, are curcumin, some curcumin derivatives and curcumin analogues. One of curcumin analogues that has been  developed is pentagamavunon-0 (PGV-0) whose IUPAC name is 2,5-bis(4'-hidroxy-3'-methoxy-benzylidene)cyclo-pentanone. But PGV-0, which is like curcumin, practically insoluble in water, so it causes problems in the development. The aim of this research is to synthesize a derivative of PGV-0, a natrium salt of PGV-0 (natrium pentagamavunonate-0/Na-pentagamavunonate-0), which is hoped to have a better anti-inflammatory activity and solubility in water than PGV-0. PGV-0 was synthesized by reacting vanillin and cyclopentanone catalized by acid. Na-pentagamavunonate-0 was synthesized with PGV-0 as a starting material using an appropriate method. This research was able to synthesize new compound that was estimated as a natrium salt of PGV-0 (natrium pentagamavunonate-0/Na-pentagamavunonate-0).   Keywords: Curcumin, PGV-0, Na-pentagamavunonate-0, anti-inflammation

scholarly journals Demonstration of Phytochemicals and In-vitro Antioxidant and Anti-inflammatory activity by methanolic extract of Elettaria cardamomum

2020 ◽  
Vol 3 (3) ◽  
pp. 01-04
Author(s):  
Md. Shahidul Islam
Keyword(s):  
Methanolic Extract ◽  
Research Work ◽  
Inflammatory Activity ◽  
Pharmacological Activities ◽  
Elettaria Cardamomum ◽  
Ic50 Values ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Dpph Scavenging

The existing research study attempts to untie novel avenues for development of the medicinal exercises of Elettaria cardamomum, fashionable known as the “Queen of Spices” and locally recognized as “elaichi”. Its seeds are utilized as abortifacient, acrid, alexiteric, aromatic, sweet, cardiac tonic, cooling, carminative, digestive, diuretic, expectorant, stimulant and also tonic beneficial in the asthma, haemorrhoids, bronchitis, strangury, renal in addition to vesical calculi, anorexia, halitosis, gastropathy dyspepsia as well as burning sensation. The prime goal of this research work is to evaluate antioxidant as well as anti-inflammatory properties of the traditional Bangladeshi medicinal extracts in addition to examine these activities. The aim in present work was to screen the phytochemical profile as well as pharmacological activities of the methanolic extract of this plant’s leaves. To explore pharmacological actions DPPH scavenging test and the HRBC membrane stabilization techniques were done for the antioxidant and also anti-inflammatory test respectively. The pharmacological works revealed that plant extracts might have noteworthy antioxidant effect which is possibly mediated by the inhibition of DPPH free radical which is accountable for oxidation. The IC50 values by the DPPH scavenging test observed for the standard and the leaves were 106.38µg/ml & 594.47µg/ml respectively. There is also moderate anti-inflammatory activity. The IC50 values for anti-inflammatory activity by standard & leaves were 35.04µg/ml and 944.0 µg/ml respectively.

Archidendron lucidum Exerts Anti-Inflammatory Effects by Targeting PDK1 in the NF-κB Pathway

2020 ◽  
Vol 48 (02) ◽  
pp. 429-444
Author(s):  
Minkyeong Jo ◽  
Young-Su Yi ◽  
Jae Youl Cho
Keyword(s):  
Signaling Pathway ◽  
Hplc Analysis ◽  
Inflammatory Diseases ◽  
Interleukin 1 ◽  
Inflammatory Activity ◽  
Raw264.7 Cells ◽  
Luciferase Reporter ◽  
No Production ◽  
Pharmacological Activities ◽  
Anti Inflammatory

Pharmacological activities of some Leguminosae family members were reported. Pharmacological activities of Archidendron lucidum, a Leguminosae family member have never been explored. Therefore, this study investigated anti-inflammatory effects of an Archidendron lucidum methanol extract (Al-ME). In this study, anti-inflammatory effects of Al-ME were investigated in LPS-stimulated RAW264.7 cells and HCl/EtOH-induced gastritis mice by MTT assay, nitric oxide (NO) production assay, semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), luciferase reporter assay, and Western blotting. High-performance liquid chromatography (HPLC) analysis identified ethnopharmacological compounds in Al-ME. Al-ME inhibited NO production without cytotoxicity in peritoneal macrophages and RAW264.7 cells stimulated with LPS or Pam3CSK4. Al-ME downregulated mRNA expression of inflammatory genes (inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2)) and pro-inflammatory cytokines (tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1[Formula: see text] (IL-1[Formula: see text]), and IL-6). Al-ME exerted anti-inflammatory activity in LPS-stimulated RAW264.7 cells by inhibiting nuclear factor-kappa B (NF-[Formula: see text]B) signaling pathway. HPLC analysis identified quercetin, luteolin, and kaempferol as major anti-inflammatory components in Al-ME. Al-ME ameliorated HCl/EtOH-induced gastritis symptoms in mice by suppressing iNOS and IL-6 mRNA expressions and I[Formula: see text]B[Formula: see text] phosphorylation. Therefore, these results suggest that Al-ME exhibited anti-inflammatory activity by targeting NF-[Formula: see text]B signaling pathway, implying that Al-ME could be potent anti-inflammatory medications to prevent and treat inflammatory diseases.

scholarly journals The anti-inflammatory activity of licorice, a widely used Chinese herb

2016 ◽  
Vol 55 (1) ◽  
pp. 5-18 ◽  
Author(s):  
Rui Yang ◽  
Bo-Chuan Yuan ◽  
Yong-Sheng Ma ◽  
Shan Zhou ◽  
Ying Liu
Keyword(s):  
Chinese Herb ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals A PROPOLIS AS A HEALING AGENT FOR PULP INJURIES

2021 ◽  
Vol 1 (2) ◽  
pp. 68-76
Author(s):  
Mirza Aryanto ◽  
Siti Nur Khairunnisa Alala
Keyword(s):  
Traditional Medicine ◽  
Biological Functions ◽  
Active Components ◽  
Pharmacological Activities ◽  
Natural Resin ◽  
Healing Agent ◽  
Anti Inflammatory ◽  
Online Library ◽  
Biological And Pharmacological Activities

As one of the natural resin materials produced by bees, propolis has been used as a traditional medicine for various diseases because of its biological and pharmacological activities. The purpose of this study was to analyze the potential of propolis as a healing agent for pulp injuries. A total of 35 journals from PubMed, Ebsco, ResearchGate, Wiley Online Library, and other international journal databases were analyzed. Propolis is very rich in active components such as flavonoids that have biological functions such as anti-inflammatory, antibacterial, antifungal and antioxidant which can act as a potential healing agent

scholarly journals Oleanane- and ursane- type triterpenoids from Eugenia grandis

2019 ◽  
Vol 18 (1) ◽  
pp. 50-57
Author(s):  
Manoharan Karuppiah Pillai ◽  
David James Young
Keyword(s):  
Spectral Data ◽  
Stem Bark ◽  
Chloroform Extract ◽  
Ayurvedic Medicine ◽  
Asiatic Acid ◽  
Pharmacological Activities ◽  
Arjunolic Acid ◽  
Anti Inflammatory ◽  
Biological And Pharmacological Activities

Arjunolic acid (an oleanane-type triterpenoid) and asiatic acid (an ursane-type triterpenoid) were obtained as an inseparable mixture from a chloroform extract of stem-bark of Eugenia grandis (Myrtaceae). They were characterised mainly by analysis of their spectral data. Arjunolic acid and asiatic acid are reported to have a variety of biological and pharmacological activities, which include antibacterial, anti-inflammatory, antioxidant, antidiabetic, antihyperlipidemic, cardiacprotective, antitumor, anticancer and hepatoprotective activities. Arjunolic acid has been used as a cardio-protective phytotonic in traditional Ayurvedic medicine for centuries.

scholarly journals In vitro and In vivo Models for Anti-inflammation: An Evaluative Review

2019 ◽  
pp. 3-15 ◽  
Author(s):  
Fabian Ifeanyi Eze ◽  
Philip F. Uzor ◽  
Peter Ikechukwu ◽  
Bonaventure C. Obi ◽  
Patience O. Osadebe
Keyword(s):  
Inflammatory Activity ◽  
Assay Method ◽  
In Vivo Models ◽  
Synthetic Drugs ◽  
Mediators Of Inflammation ◽  
In Vivo Animal Models ◽  
Anti Inflammatory ◽  
Anti Inflammation

Anti-inflammatory activity study involves developing a model that mimics, or provokes the production or release of, the biochemical mediators of inflammation, and monitoring the response of these biochemicals to the test drugs. This report constitutes an updated review of the in vitro and in vivo study models for assessing anti-inflammatory activity in plant extracts and synthetic drugs. The materials, instrumentation, and methods involved, as well as the mechanism of anti-inflammatory activity tested in each model, are extensively described. The merits and limitations of each method have also been discussed. A comparative assessment of the in vivo animal models vis-à-vis, the in vitro enzyme models have been made to assist scientists and researchers in the choice of assay method in terms of sensitivity, reliability, duration of test, ethical, and cost considerations.

scholarly journals The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

2019 ◽  
Vol 87 (1) ◽  
pp. 3 ◽  
Author(s):  
Lusi Dwita ◽  
Kori Yati ◽  
Sri Gantini
Keyword(s):  
Topical Application ◽  
Acute Inflammation ◽  
Nigella Sativa ◽  
Inflammatory Activity ◽  
Nigella Sativa Oil ◽  
Paw Oedema ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Anti Inflammation

Nigella sativa oil has been known to have potent anti-inflammatory activity. This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical application. The activity was checked using two methods: carrageenan-induced paw oedema and granuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa could overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%), low leucocytes count (43.55% lower than control) as well as a notable TNF-α concentration (50% lower than control) on the inflamed area. In conclusion, topical application of a Nigella sativa balm stick was effective for both acute and sub-acute forms of inflammation.

scholarly journals Experimental study of inclusion expediency of the white willow extractin the hydrogel of anti-arthrosis action

2007 ◽  
Vol 6 (2) ◽  
pp. 26-30
Author(s):  
D. V. Kompantsev
Keyword(s):  
Experimental Study ◽  
Proliferative Activity ◽  
Inflammatory Activity ◽  
Proliferative Stage ◽  
Combined Use ◽  
Glucosamine Sulphate ◽  
White Willow ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Anti Inflammation

The analysis of acute toxicity and anti-inflammation activity of the willow extract is performed expediency of its inclusion in the preparations with anti-arthrosis activity. The dose dependent study of anti-inflammatory activity of willow extract was carried out of the model of acute inflammatory swelling which was provoked by introduction of 0.1 ml of 10% kaolin in the hind leg of the rat. Comparative anti-inflammatory activity of glucosamine sulphate and hydrogel in experimental osteoarthrosis was studied by modeling of inflammation. Most marked anti-inflammatory activity was shown to have the willow extract in the doses of 100 and 200 mg/kg. Inclusion of the willow extract in granules increased anti-proliferative activity of glucosamine in experimental osteoarthrosis. Combined use of the willow extract with glucosamine more effective than monotherapy by glucosamine, influenced suppressively on proliferative stage of inflammation in experimental osteoarthosis.

scholarly journals In vitro and in vivo anti-inflammatory activity of Dillenia pentagyna Roxb. bark, a folklore medicine of Mizoram

2017 ◽  
Vol 17 (2) ◽  
pp. 69-77
Author(s):  
Zothanpuia ◽  
Bibhuti K. Kakoti
Keyword(s):  
Methanolic Extract ◽  
Inflammatory Activity ◽  
Endangered Plants ◽  
Pharmacological Activities ◽  
North East India ◽  
Rich Variety ◽  
North East ◽  
Anti Inflammatory

Natural products have played an exceptionally important role in health care and prevention of diseases for thousands of years and are one of the greatest sources of medicine. Mizoram is a home to a rich variety of flora and fauna however; very less systematic survey and documentation were carried out to date. The plant diversity of Mizoram is not adequately studied as compared to other states of north east India. Dillenia pentagyna Roxb., known as kaihzawl in Mizo and dog teak in English, is one of the endangered plants that is yet to be explore. The Mizo communities use the decoction of D. pentagyna bark to treat different stomach ailments, inflammation and diabetes. In this perspective, the methanolic extract of the bark of D. pentagyna was evaluated for its anti-inflammatory properties. The extract showed the presence of flavanoids, triterpenoids, steroids, phenolics, saponins, fixed oils and others exerting varied pharmacological activities. The methanolic extract of this plant was found to contain active constituents such as betulinic acid and β-sitosterol which are found to actively interact with the inflammatory mediators and suppressed the inflammation when evaluated for its in vitro and in vivo anti-inflammatory activity. The present study suggests that the methanolic extract of D. pentagyna bark showed significant anti-inflammatory activity. This study also support the folkloric used of the plant in diseases related to inflammatory condition.

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