Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice

2015 ◽  
Vol 6 (5) ◽  
pp. 1418-1427 ◽  
Author(s):  
Wei Li ◽  
Ying Liu ◽  
Zi Wang ◽  
Ye Han ◽  
Yu-Hong Tian ◽  
...  
Keyword(s):  
Liver Injury ◽  
Biological Effects ◽  
Platycodon Grandiflorum ◽  
Platycodin D ◽  
Aerial Parts ◽  
Anti Inflammation

Platycodin D (PD) is the main active saponin of Platycodon grandiflorum (PG) and is reported to exhibit multiple biological effects, including anti-tumor, anti-inflammation, and anti-obesity properties.

scholarly journals Antihepatotoxic Activity of Phyllanthus atropurpureus Cultivated in Egypt

2011 ◽  
Vol 66 (9-10) ◽  
pp. 447-452 ◽  
Author(s):  
Taha Sarg ◽  
Afaf Abdel Ghani ◽  
Rawia Zayed ◽  
May El-Sayed
Keyword(s):  
Liver Injury ◽  
Active Ingredient ◽  
Ornamental Plants ◽  
Hepatoprotective Activity ◽  
Maximum Activity ◽  
Phytochemical Analysis ◽  
Root Extract ◽  
Aerial Parts ◽  
Serum Aspartate Aminotransferase ◽  
Antihepatotoxic Activity

The genus Phyllanthus (family Euphorbiaceae) is considered one of the important medicinal and ornamental plants. A phytochemical analysis of the extracts was performed to search for the active ingredient. Results of the investigation of the hepatoprotective activity of Phyllanthus atropurpureus Boj. Hort. Maurit. revealed that the activities of alcoholic extracts of its aerial parts and roots were quite similar to those of silymarin. Both of them improve the parameters of CCl4-induced liver injury including serum aspartate aminotransferase and alanine aminotransferase. Among the extracts tested, the root extract showed maximum activity compared to the aerial parts extract and to silymarin.

scholarly journals A Polyphenol-Rich Fraction from Eugenia uniflora Exhibits Antioxidant and Hepatoprotective Activities In Vivo

2020 ◽  
Vol 13 (5) ◽  
pp. 84
Author(s):  
Mansour Sobeh ◽  
Marwa S. Hamza ◽  
Mohamed L. Ashour ◽  
Mona Elkhatieb ◽  
Mohamed A El Raey ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Ethyl Acetate ◽  
Acute Liver Injury ◽  
Antioxidant Activities ◽  
Biological Effects ◽  
Ethyl Acetate Fraction ◽  
Eugenia Uniflora ◽  
Quercetin Derivatives

Leaves from Eugenia uniflora, the red Brazilian cherry, have a high content of flavonoids that possess several biological effects such as anti-inflammatory, antioxidant, and antidiabetic activities. However, their influence on carbon tetrachloride (CCl4)-induced acute liver injury in rats has not been investigated. In the current study, a bioguided fractionation assay revealed that the ethyl acetate fraction (EAF) of Eugenia uniflora is the safest and most active fraction. LC-MS analysis of the ethyl acetate fraction revealed 22 secondary metabolites, mainly myricetin and quercetin derivatives. EAF did not show toxicity up to 2000 mg/kg, and exhibited antioxidant activities in vitro in DPPH assay with IC50 of 3.35 µg/mL. Additionally, EAF exhibited substantial antioxidant activities in vivo by counteracting the oxidative damage of the prooxidant juglone [80 µM] in Caenorhabditis elegans model organism and increased its survival rate in a dose-dependent fashion through the DAF-16/Foxo pathway. Furthermore, the hepatoprotective activity of EAF (200 mg/kg against carbon tetrachloride (CCl4) intoxicated male Wistar rats was assessed. EAF significantly inhibited CCl4-induced elevation of alanine aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (TB), total cholesterol (TC), and triglycerides (TG), in the blood serum and prevented lipid peroxidation and restored superoxide dismutase (SOD) activity and glutathione (GSH) content in liver tissues. The observed hepatoprotective effects of EAF, which were supported by histopathological observations as pretreatment with EAF, effectively attenuated the CCl4-induced histopathological changes. In conclusion, EAF of Eugenia uniflora leaves has substantial hepatoprotective activities against CCl4 induced acute liver injury in rats due to its antioxidant activity.

Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice

2012 ◽  
Vol 50 (12) ◽  
pp. 4254-4259 ◽  
Author(s):  
Tae-Won Kim ◽  
In-Bae Song ◽  
Hong-Ki Lee ◽  
Jong-Hwan Lim ◽  
Eun-Sang Cho ◽  
...  
Keyword(s):  
Platycodon Grandiflorum ◽  
Platycodin D

scholarly journals Ten Years’ Research on a Cardiovascular Tonic: A Comprehensive Approach—From Quality Control and Mechanisms of Action to Clinical Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ping-Chung Leung ◽  
Chi-Man Koon ◽  
Clara Bik-San Lau ◽  
Ping Chook ◽  
William King-Fai Cheng ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cardiovascular Health ◽  
Foam Cell ◽  
Biological Effects ◽  
Cell Formation ◽  
Surrogate Marker ◽  
Foam Cell Formation ◽  
Herbal Formula ◽  
Interventional Therapies ◽  
Anti Inflammation

Objective. Mortality arising from cardiovascular pathologies remains one of the highest. Maintenance of cardiovascular health therefore remains a universal concern. Interventional therapies and medications have made impressive advances, but preventive measures would be of the same importance.Method. Ten years’ search for a simple herbal formula has resulted in a two-herb combination, consisting ofSalviae Miltiorrhizae Radix et RhizomaandPuerariae Lobatae Radix. The formula has been studied extensively on cardiovascular biological platforms and then put on three clinical trials.Results. In the laboratory, the formula was found to have the biological effects of anti-inflammation, anti-oxidation, anti-foam cell formation on vascular endothelium, and vasodilation. Clinical trials using ultrasonic carotid intima thickness as a surrogate marker showed very significant benefits. No significant adverse effects were encountered.Conclusion. It is therefore recommended that the herbal formula could be used as an adjuvant therapy in cardiac patients under treatment or as a preventive agent among the susceptible.

Influence of small doses of various drug vehicles on acetaminophen-induced liver injury

2010 ◽  
Vol 88 (10) ◽  
pp. 960-967 ◽  
Author(s):  
Tomislav Kelava ◽  
Ivan Ćavar ◽  
Filip Čulo
Keyword(s):  
Liver Injury ◽  
Propylene Glycol ◽  
Reduced Glutathione ◽  
Biological Effects ◽  
Tween 20 ◽  
Histopathological Changes ◽  
Acetaminophen Toxicity ◽  
Small Doses ◽  
Injury Assessment ◽  
Drug Vehicle

The biological effects of drug vehicles are often overlooked, often leading to artifacts in acetaminophen-induced liver injury assessment. Therefore, we decided to investigate the effect of dimethylsulfoxide, dimethylformamide, propylene glycol, ethanol, and Tween 20 on acetaminophen-induced liver injury. C57BL/6 male mice received a particular drug vehicle (0.6 or 0.2 mL/kg, i.p.) 30 min before acetaminophen administration (300 mg/kg, i.p.). Control mice received vehicle alone. Liver injury was assessed by measuring the concentration of alanine aminotransferase in plasma and observing histopathological changes. The level of reduced glutathione (GSH) was assessed by measuring total nonprotein hepatic sulfhydrils. Dimethylsulfoxide and dimethylformamide (at both doses) almost completely abolished acetaminophen toxicity. The higher dose of propylene glycol (0.6 mL/kg) was markedly protective, but the lower dose (0.2 mL/kg) was only slightly protective. These solvents also reduced acetaminophen-induced GSH depletion. Dimethylformamide was protective when given 2 h before or 1 h after acetaminophen administration, but was ineffective if given 2.5 h after acetaminophen. Ethanol at the higher dose (0.6 mL/kg) was partially protective, whereas ethanol at the lower dose (0.2 mL/kg) as well as Tween 20 at any dose had no influence. None of the vehicles (0.6 mL/kg) was hepatotoxic per se, and none of them was protective in a model of liver injury caused by d-galactosamine and lipopolysaccharide.

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