Plant protein-based delivery systems for bioactive ingredients in foods

2015 ◽  
Vol 6 (9) ◽  
pp. 2876-2889 ◽  
Author(s):  
Zhi-Li Wan ◽  
Jian Guo ◽  
Xiao-Quan Yang
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Functional Foods ◽  
Delivery Systems ◽  
Plant Protein ◽  
Food Ingredients ◽  
Food Grade ◽  
Research Fields ◽  
System P ◽  
Bioactive Ingredients

The application of food-grade delivery systems for the encapsulation, protection and controlled release of bioactive food ingredients have recently gained increasing interest in the research fields of functional foods and pharmaceutics. The preparation and application of bifunctional particles provide a novel perspective for the design of plant protein-based delivery system.

Halloysite nanotubes as a new drug-delivery system: a review

Clay Minerals ◽  
2016 ◽  
Vol 51 (3) ◽  
pp. 469-477 ◽  
Author(s):  
Muhammad Hanif ◽  
Fazila Jabbar ◽  
Sana Sharif ◽  
Ghulam Abbas ◽  
Athar Farooq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Halloysite Nanotubes ◽  
Delivery Systems ◽  
New Drug ◽  
Wide Range ◽  
Loading Methods

AbstractNew drug-delivery systems have remained a challenge for pharmaceutical scientists due to the use of expensive polymers and the low loading capacity of prepared nanoparticles. There is pressure to develop formulations that contain not only cheaper materials but also have controlled-release properties. Halloysite nanotubes (HNTs) are a naturally occurring clay mineral similar to kaolin, possessing a special particle shape in the form of an ultramicroscopic multilayered hollow cylinder. Its uses encompass a wide range in anticancer therapy, sustained- and controlled-release drug-delivery systems, cosmetics, delivery of proteins, vaccines and genes. These advantages are due to its biocompatibility, significant mechanical strength and natural availability. The surfaces of the tubules can be modified by coating different polymers for application in the drug-delivery system. This review is focused on the various aspects of HNTs such as structure, properties, loading methods, applications and characterizations.

Formation of pH-responsive drug-delivery systems by electrospinning of vesicle-templated nanocapsule solutions

RSC Advances ◽  
2016 ◽  
Vol 6 (48) ◽  
pp. 42589-42595 ◽  
Author(s):  
W. Li ◽  
X. N. Tan ◽  
T. Luo ◽  
X. Huang ◽  
Q. Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sodium Alginate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Electrospinning Process ◽  
Nanofibrous Membrane ◽  
Ph Responsive ◽  
System P

A novel nanofibrous membrane, which contains chitosan/sodium alginate nanocapsules constructed by vesicle systems, has been fabricated via an electrospinning process as a drug-delivery system.

scholarly journals Correction: In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3623-3623
Author(s):  
Junyan Yao ◽  
Shijie Zhang ◽  
Wudan Li ◽  
Zhi Du ◽  
Yujie Li
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
System P

Correction for ‘In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system’ by Junyan Yao et al., RSC Adv., 2016, 6, 515–521.

Solid lipid nanoparticle enhances bioavailability of hydroxycitric acid compared to a microparticle delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 53784-53793 ◽  
Author(s):  
P. N. Ezhilarasi ◽  
S. P. Muthukumar ◽  
C. Anandharamakrishnan
Keyword(s):  
Controlled Release ◽  
Bioactive Compounds ◽  
Delivery System ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Hydroxycitric Acid ◽  
System P ◽  
The Stability

Solid lipid nanoparticles (SLN) are the most promising delivery system that improves the stability, bioavailability and controlled release of food bioactive compounds.

scholarly journals A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 420
Author(s):  
Eleni Spanidi ◽  
Athanasios Karapetsas ◽  
Georgia-Persephoni Voulgaridou ◽  
Sophia Letsiou ◽  
Nektarios Aligiannis ◽  
...  
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Functional Foods ◽  
Biochemical Activity ◽  
Polyphenol Content ◽  
Transcript Accumulation ◽  
Skin Cells ◽  
Methanolic Extracts ◽  
Cultured Skin ◽  
Physicochemical Stability

Propolis is a resinous substance produced by bees that exhibits antimicrobial, immunostimulatory and antioxidant activity. Its use is common in functional foods, cosmetics and traditional medicine despite the fact that it demonstrates low extraction yields and inconsistency in non-toxic solvents. In this work, a new encapsulation and delivery system consisting of liposomes and cyclodextrins incorporating propolis polyphenols has been developed and characterized. The antioxidant, antimutagenic and antiaging properties of the system under normal and UVB-induced oxidative stress conditions were investigated in cultured skin cells and/or reconstituted skin model. Furthermore, the transcript accumulation for an array of genes involved in many skin-related processes was studied. The system exhibits significant polyphenol encapsulation efficiency, physicochemical stability as well as controlled release rate in appropriate conditions. The delivery system can retain the anti-mutagenic, anti-oxidative and anti-ageing effects of propolis polyphenols to levels similar and comparable to those of propolis methanolic extracts, making the system ideal for applications where non-toxic solvents are required and controlled release of the polyphenol content is desired.

Facile dynamic one-step modular assembly based on boronic acid-diol for construction of a micellar drug delivery system

2018 ◽  
Vol 6 (10) ◽  
pp. 2605-2618 ◽  
Author(s):  
Zekai Zhao ◽  
Ying Zhang ◽  
Chunli Tian ◽  
Tingjie Yin ◽  
Can Zhang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Boronic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Modular Assembly ◽  
Assembly Strategy ◽  
System P ◽  
One Step

This study reports a facile and dynamic one-step modular assembly strategy based on boronic acid-diol for constructing focus-responsive micellar drug delivery systems.

scholarly journals GASTRO RETENTIVE DRUG DELIVERY SYSTEM: A SIGNIFICANT TOOL TO INCREASE THE GASTRIC RESIDENCE TIME OF DRUGS

2021 ◽  
pp. 7-11
Author(s):  
KANUPRIYA C. ◽  
NIMRATA SETH ◽  
N. S. GILL
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Residence Time ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Site Specific ◽  
Gastro Retentive

Writing the review on gastro retentive drug delivery systems (GRDDS) was to start up the current literature with a special consequence on several gastro retentive approaches that have become main mode in the field of site-specific orally conduct sustained/controlled release drug delivery. Multi-furious ways have been made in research and development to rate-controlled oral drug delivery systems to solve physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). GRDDS is a tool to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Oral dosage forms as low bioavailability issues because of their swift gastric transition from the stomach, particularly in the case of drugs that are less soluble at an alkaline pH of the intestine. The drugs that produce their local action in the stomach get quickly emptied and don’t get enough residence time in the stomach. Many efforts have been made to extend the retention time of a drug delivery system to reduce the frequency of dose administration. GRDDS not only prolong dosing intervals but also increase patient compliance beyond the level of existing controlled release dosage forms. This article gives an overview of the advantages, disadvantages, and characterization of gastro retentive drug delivery systems. This also includes commercially available gastro retentive products and patents.

scholarly journals Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

2016 ◽  
Vol 52 (22) ◽  
pp. 4187-4190 ◽  
Author(s):  
T. L. Harris ◽  
C. J. Wenthur ◽  
A. Diego-Taboada ◽  
G. Mackenzie ◽  
T. S. Corbitt ◽  
...  
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Botulinum Neurotoxin ◽  
Botulinum Neurotoxin A ◽  
Lycopodium Clavatum ◽  
System P ◽  
Ph Dependent

Biopolymeric spores and shellac can be rapidly employed to generate a scalable, pH-dependent, controlled-release microcapsule delivery system.

scholarly journals Formulation and evaluation of Norfloxacin gastro retentive drug delivery systems using natural polymers

2012 ◽  
Vol 1 (7) ◽  
pp. 155-164 ◽  
Author(s):  
P D Thahera ◽  
Mr Ashok ◽  
K Latha ◽  
T Shailaja ◽  
S Nyamathulla ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Guar Gum ◽  
Delivery Systems ◽  
Release Profile ◽  
Time Duration

Gastric retentive floating drug delivery system (GFDDS) is enabled the prolonged continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improves the bioavailability of medications with narrow absorption window. The design of the delivery system is based on the controlled release formulation with floating and swelling features in order to prolong the gastric retention time of the drug delivery systems. In the present study norfloxacin as candidate, guar gum, sodium CMC, HPMC15 KM is studied along with other excipients like PVP K30 (binder), sodium bicarbonate microcrystalline cellulose were used in different concentrations to get the desired controlled release profile over a period of 12 hrs. All the formulations were evaluated for buoyancy lag time, duration of buoyancy, dimensional stability, drug content and in vitro drug release profile. Based on the in vitro studies carried out for the optimized formulation by dissolution the performance of the developed formulation promises to be efficient in controlling the drug release rate with the guar gum, a natural polymer.DOI: http://dx.doi.org/10.3329/icpj.v1i7.10809International Current Pharmaceutical Journal 2012, 1(7): 155-164 

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