scholarly journals DNA binding properties, histidine interaction and cytotoxicity studies of water soluble ruthenium(ii) terpyridine complexes

2016 ◽  
Vol 45 (11) ◽  
pp. 4633-4646 ◽  
Author(s):  
Dejan Lazić ◽  
Aleksandar Arsenijević ◽  
Ralph Puchta ◽  
Živadin D. Bugarčić ◽  
Ana Rilak
Keyword(s):  
Dna Binding ◽  
Competitive Binding ◽  
Water Soluble ◽  
Binding Studies ◽  
Binding Properties ◽  
Cytotoxicity Studies ◽  
Vis Spectroscopy ◽  
Spectroscopy Studies ◽  
Ct Dna ◽  
Dna Binding Properties

UV-Vis spectroscopy studies, viscosity measurements and competitive binding studies with EB have revealed the ability of the complexes to bind to CT DNA covalently through N7 of guanine residues and non-covalently through intercalation.

DNA-Binding Properties and Photocleavage Activity of Cationic Water-Soluble Chlorophyll Derivatives

2006 ◽  
Vol 12 (24) ◽  
pp. 6331-6340 ◽  
Author(s):  
Hidetoshi Taima ◽  
Akihiro Okubo ◽  
Naoki Yoshioka ◽  
Hidenari Inoue
Keyword(s):  
Dna Binding ◽  
Water Soluble ◽  
Binding Properties ◽  
Dna Binding Properties ◽  
Chlorophyll Derivatives

Synthesis, Crystal Structure, and DNA-Binding Studies of a Ni(II) Complex with the Tris(N-methylbenzimidazol-2-ylmethyl)amine Ligand

2010 ◽  
Vol 65 (11) ◽  
pp. 1341-1348 ◽  
Author(s):  
Huilu Wu ◽  
Ke Li ◽  
Tao Sun ◽  
Bin Liu ◽  
Fei Jia ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Distorted Octahedral Geometry ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Binding Properties ◽  
Distorted Octahedral ◽  
Elemental Analyses ◽  
Dna Binding Studies ◽  
Dna Binding Properties

A tripod ligand tris(N-methylbenzimidazol-2-ylmethyl)amine (Mentb) and its nickel(II) picrate (pic) complex, with composition [Ni(Mentb)(DMF)(H2O)](pic)2, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/Vis measurements. Single-crystal X-ray diffraction revealed that the Ni atom is six-coordinated in a distorted octahedral geometry. In addition, the DNA-binding properties of the ligand Mentb and its Ni(II) complex have been investigated by electronic absorption, fluorescence and viscosity measurements. The experimental results suggest that the ligand and its Ni(II) complex bind to DNA via an intercalation binding mode, and their binding affinity to DNA follows the order of complex>ligand.

scholarly journals Synthesis, Crystal Structure, and DNA-Binding Studies of a Nickel(II) Complex with the Bis(2-benzimidazolymethyl)amine Ligand

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Huilu Wu ◽  
Tao Sun ◽  
Ke Li ◽  
Bin Liu ◽  
Fan Kou ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Coordination Geometry ◽  
Binding Studies ◽  
Binding Properties ◽  
Elemental Analyses ◽  
Dna Binding Studies ◽  
Intercalation Binding ◽  
Dna Binding Properties ◽  
Amine Ligand

A V-shaped ligand Bis(2-benzimidazolymethyl)amine (bba) and its nickel(II) picrate (pic) complex, with composition [Ni(bba)2](pic)2⋅3MeOH, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/vis measurements. In the complex, the Ni(II) ion is six-coordinated with a N2O4ligand set, resulting in a distorted octahedron coordination geometry. In addition, the DNA-binding properties of the Ni(II) complex have been investigated by electronic absorption, fluorescence, and viscosity measurements. The experimental results suggest that the nickel(II) complex binds to DNA by partial intercalation binding mode.

Fluorescent and Ultraviolet—Visible Spectroscopy Studies on the Antioxidation and DNA Binding Properties of Binuclear Tb(III) Complexes

2010 ◽  
Vol 64 (9) ◽  
pp. 980-985 ◽  
Author(s):  
Yongchun Liu ◽  
Xinhui Jiang ◽  
Zhengyin Yang ◽  
Xudong Zheng ◽  
Jianning Liu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Visible Spectroscopy ◽  
Binding Properties ◽  
Spectroscopy Studies ◽  
Dna Binding Properties

Synthesis, Characterization, DNA Binding, and Photocleavage of [Ru(bpy)2(MFIP)]2+ and [Ru(phen)2(MFIP)]2+

2008 ◽  
Vol 61 (9) ◽  
pp. 725 ◽  
Author(s):  
Lifeng Tan ◽  
Sheng Zhang ◽  
Xiaohua Liu ◽  
Yue Xiao
Keyword(s):  
Mass Spectrometry ◽  
Dna Binding ◽  
1H Nmr Spectroscopy ◽  
Binding Properties ◽  
Experimental Conditions ◽  
Spectrophotometric Methods ◽  
Calf Thymus ◽  
Pbr322 Dna ◽  
Ct Dna ◽  
Dna Binding Properties

The new ligand 2-(5-methyl-furan-2-yl)imidazo[4,5-f][1, 10]phenanthroline (MFIP) and its complexes [Ru(bpy)2(MFIP)]2+ 1 (bpy = 2,2′-bipyridine) and [Ru(phen)2(MFIP)]2+ 2 (phen = 1,10-phenanthroline) were synthesized and characterized by elemental analysis, mass spectrometry, and 1H NMR spectroscopy. The DNA binding properties of the two complexes were investigated by different spectrophotometric methods and viscosity measurements. The results suggest that both complexes bind to calf thymus DNA (CT-DNA) through intercalation, and both complexes can enantioselectively interact with CT-DNA. The Λ enantiomers of both complexes are slightly predominant for binding to CT-DNA over the Δ enantiomer. When irradiated at 400 nm, the two complexes promote the photocleavage of pBR322 DNA, and complex 2 cleaves DNA more effectively than complex 1 under comparable experimental conditions. Furthermore, mechanism studies reveal that singlet oxygen (1O2) plays a significant role in the photocleavage.

Synthesis and evaluation of the in vitro DNA-binding properties of chiral cis-dichloro(pyridyloxazoline)platinum(II) complexes

2009 ◽  
Vol 87 (1) ◽  
pp. 321-327 ◽  
Author(s):  
David W Dodd ◽  
Heather E Toews ◽  
Michael J Trevail ◽  
Michael C Jennings ◽  
Robert HE Hudson ◽  
...  
Keyword(s):  
Dna Binding ◽  
Hplc Analysis ◽  
Polyacrylamide Gel Electrophoresis ◽  
Metal Exposure ◽  
Binding Studies ◽  
Binding Properties ◽  
Double Stranded Dna ◽  
Dna Binding Studies ◽  
Dna Binding Properties

A series of chiral cis-dichloro(pyridyloxazoline)platinum(II) and palladium(II) complexes were synthesized and their reactivity towards a defined sequence of single-stranded and double-stranded DNA was investigated in comparison to cisplatin. The compounds differed in the nature and absolute configuration of the substituent at the C4 position of the oxazoline ring. The DNA-binding ability of these compounds was evaluated by HPLC analysis, post metal exposure, of enzymatic digests of an undecamer duplex containing one putative metallation site. Polyacrylamide gel electrophoresis (PAGE) and thermal denaturation confirmed the results of the HPLC analysis, which showed that the stereochemistry and character of the substituent at the C4 position of the oxazoline ring had little effect on DNA binding, possibly due to the formation of monofunctional adducts.Key words: cisplatin, chiral, pyridyloxazoline, DNA-binding studies, platinum, palladium.

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