A series of phenyl sulfonate metal coordination polymers as catalysts for one-pot Biginelli reactions under solvent-free conditions

2015 ◽  
Vol 44 (40) ◽  
pp. 17829-17840 ◽  
Author(s):  
Jin-Hua Wang ◽  
Gui-Mei Tang ◽  
Yong-Tao Wang ◽  
Yue-Zhi Cui ◽  
Jun-Jie Wang ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Solvent Free ◽  
Metal Coordination ◽  
Hydrothermal Conditions ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Biginelli Reactions ◽  
Biginelli Condensation ◽  
Metal Coordination Polymers ◽  
Catalytic Performances

A series of phenyl sulfonate metal coordination polymers have been obtained under hydrothermal conditions, which show high catalytic performances for one-pot Biginelli condensation reactions under solvent-free conditions.

Phytic acid: a biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones

RSC Advances ◽  
2014 ◽  
Vol 4 (38) ◽  
pp. 19710-19715 ◽  
Author(s):  
Qiguo Zhang ◽  
Xin Wang ◽  
Zhenjiang Li ◽  
Wenzhuo Wu ◽  
Jingjing Liu ◽  
...  
Keyword(s):  
Phytic Acid ◽  
Solvent Free ◽  
One Pot ◽  
Bifunctional Mechanism ◽  
Solvent Free Conditions ◽  
Biginelli Reactions

PhyA as a biogenic organocatalyst for Biginelli reactions under solvent-free conditions with good yields and by a plausible bifunctional mechanism.

scholarly journals Gypsum-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)Under Solvent-Free Conditions

2011 ◽  
Vol 8 (1) ◽  
pp. 312-318 ◽  
Author(s):  
Taoues Boumoud ◽  
Boudjemaa Boumoud ◽  
Paul Mosset ◽  
Abdelmadjid Debache
Keyword(s):  
Green Chemistry ◽  
Solvent Free ◽  
Biologically Active ◽  
Economic Approach ◽  
One Pot ◽  
One Pot Synthesis ◽  
Environmental Friendly ◽  
Solvent Free Conditions ◽  
Pharmaceutical Industries ◽  
Biginelli Condensation

In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one-pot Biginelli condensation in the presence of gypsum as an environmental friendly and recycled catalyst.

An efficient and reusable ionic liquid catalyst for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes under solvent-free conditions

RSC Advances ◽  
2014 ◽  
Vol 4 (68) ◽  
pp. 36031-36035 ◽  
Author(s):  
Anlian Zhu ◽  
Shukun Bai ◽  
Wei Jin ◽  
Ruixia Liu ◽  
Lingjun Li ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Synergetic Effect ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
To Come ◽  
The One ◽  
Catalytic Performances

Ionic liquid [DMEA][HSO4] was found to be an efficient and reusable catalyst for the one-pot synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes under solvent-free conditions. The excellent catalytic performances are believed to come from the synergetic effect of the cation and anion of the ionic liquid.

Chlorosulfonic Acid Supported Piperidine-4-carboxylic Acid (PPCA) Functionalized Fe3O4 Nanoparticles (Fe3O4-PPCA): The Efficient, Green and Reusable Nanocatalyst for the Synthesis of Pyrazolyl Coumarin Derivatives under Solvent-Free Conditions

2019 ◽  
Vol 22 (2) ◽  
pp. 123-128
Author(s):  
Setareh Habibzadeh ◽  
Hassan Ghasemnejad-Bosra ◽  
Mina Haghdadi ◽  
Soheila Heydari-Parastar
Keyword(s):  
Carboxylic Acid ◽  
Fe3o4 Nanoparticles ◽  
High Efficiency ◽  
Reaction Times ◽  
Chlorosulfonic Acid ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Magnetic Nanocatalyst ◽  
One Pot ◽  
Solvent Free Conditions

Background: In this study, we developed a convenient methodology for the synthesis of coumarin linked to pyrazolines and pyrano [2,3-h] coumarins linked to 3-(1,5-diphenyl-4,5- dihydro-1H-pyrazol-3-yl)-chromen-2-one derivatives using Chlorosulfonic acid supported Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) catalyst. Materials and Methods:: Fe3O4-PPCA was investigated as an efficient and magnetically recoverable Nanocatalyst for the one-pot synthesis of substituted coumarins from the reaction of coumarin with a variety of aromatic aldehydes in high to excellent yield at room temperature under solvent-free conditions. The magnetic nanocatalyst can be easily recovered by applying an external magnet device and reused for at least 10 reaction runs without considerable loss of reactivity. Results and Conclusion: The advantages of this protocol are the use of commercially available materials, simple and an inexpensive procedure, easy separation, and an eco-friendly procedure, and it shows good reaction times, good to high yields, inexpensive and practicability procedure, and high efficiency.

1, 1’-Sulfinyldiethylammonium Bis (Hydrogen Sulfate) as a Recyclable Dicationic Ionic Liquid Catalyst for the Efficient Solvent-free Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones via Biginelli Reaction

2020 ◽  
Vol 23 (2) ◽  
pp. 157-167
Author(s):  
Zainab Ehsani-Nasab ◽  
Ali Ezabadi
Keyword(s):  
Ionic Liquid ◽  
Biginelli Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Hydrogen Sulfate ◽  
One Pot ◽  
Acidic Ionic Liquid ◽  
Brønsted Acidic Ionic Liquid ◽  
Solvent Free Conditions ◽  
Dicationic Ionic Liquid

Objective: A facile and efficient method for synthesis of 3, 4-dihydropyrimidin-2(1H)-ones via Biginelli reaction catalyzed by a novel dicationic Brönsted acidic ionic liquid, [(EtNH2)2SO][HSO4]2, has been successfully developed. Material and Method:: 3, 4-Dihydropyrimidin-2(1H)-ones were synthesized through one-pot condensation of aromatic aldehydes, ethyl acetoacetate, and urea under solvent-free conditions using [(EtNH2)2SO][HSO4]2 as a novel catalyst. The progress of the reaction was monitored by thin-layer chromatography (ethyl acetate / n-hexane = 1 / 5). The products have been characterized by IR, 1H NMR, 13C NMR, and also by their melting points. Results: In this research, a library of dihydropyrimidinone derivatives was synthesized via Biginelli reaction under solvent-free conditions at 120oC using [(EtNH2)2SO][HSO4]2 as a catalyst. Various aromatic aldehydes, as well as heteroaromatic aldehydes, were employed, affording good to high yields of the corresponding products and illustrating the substrate generality of the present method. In addition, the prepared dicationic Brönsted acidic ionic liquid can be easily recovered and reused. Conclusion: 1, 1’-Sulfinyldiethylammonium bis (hydrogen sulfate), as a novel dicationic ionic liquid, can act as a highly efficient catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions.

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

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