Tricarbonyl 99mTc(i) and Re(i)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection

Dipak Kumar Nayak; Rinku Baishya; Ramalingam Natarajan; Tuhinadri Sen; Mita Chatterjee Debnath

doi:10.1039/c5dt02264a

Tricarbonyl 99mTc(i) and Re(i)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection

Dalton Transactions ◽

10.1039/c5dt02264a ◽

2015 ◽

Vol 44 (36) ◽

pp. 16136-16148 ◽

Cited By ~ 5

Author(s):

Dipak Kumar Nayak ◽

Rinku Baishya ◽

Ramalingam Natarajan ◽

Tuhinadri Sen ◽

Mita Chatterjee Debnath

Keyword(s):

Bacterial Infection ◽

Biological Evaluation ◽

Thiosemicarbazone Complexes

Tricarbonyl 99mTc(1) and Re(1) thiosemicarbazone complexes have been synthesised, characterised crystallographically and subjected to biological evaluation in rats intramuscularly infected with S. aureus.

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99mTc-Labeled Erythrocin and Biological Evaluation in Mice for Detection of Bacterial Infection

Asian Journal of Physical and Chemical Sciences ◽

10.9734/ajopacs/2018/40170 ◽

2018 ◽

Vol 5 (2) ◽

pp. 1-13 ◽

Cited By ~ 1

Author(s):

Safaa Challan ◽

A Massoud ◽

M Tawoosy ◽

M Motaleb ◽

I Borei ◽

...

Keyword(s):

Bacterial Infection ◽

Biological Evaluation

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Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation

Polyhedron ◽

10.1016/j.poly.2012.11.031 ◽

2013 ◽

Vol 50 (1) ◽

pp. 354-363 ◽

Cited By ~ 27

Author(s):

Saswati ◽

Rupam Dinda ◽

Carla S. Schmiesing ◽

Ekkehard Sinn ◽

Yogesh P. Patil ◽

...

Keyword(s):

Biological Evaluation ◽

Mixed Ligand ◽

Thiosemicarbazone Complexes

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Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents

Journal of Molecular Structure ◽

10.1016/j.molstruc.2011.02.029 ◽

2011 ◽

Vol 992 (1-3) ◽

pp. 39-47 ◽

Cited By ~ 21

Author(s):

Floyd A. Beckford ◽

Jeffrey Thessing ◽

Michael Shaloski ◽

P. Canisius Mbarushimana ◽

Alyssa Brock ◽

...

Keyword(s):

Antibacterial Agents ◽

Biological Evaluation ◽

Mixed Ligand ◽

Synthesis And Characterization ◽

Thiosemicarbazone Complexes

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Half-sandwich arene ruthenium, rhodium and iridium thiosemicarbazone complexes: synthesis, characterization and biological evaluation

Journal of Chemical Sciences ◽

10.1007/s12039-019-1731-5 ◽

2020 ◽

Vol 132 (1) ◽

Cited By ~ 2

Author(s):

Agreeda Lapasam ◽

Venkanna Banothu ◽

Uma Addepally ◽

Mohan Rao Kollipara

Keyword(s):

Biological Evaluation ◽

Thiosemicarbazone Complexes ◽

Half Sandwich

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99m Tc-labeled teicoplanin and its biological evaluation in experimental animals for detection of bacterial infection

Radiochemistry ◽

10.1134/s1066362214050154 ◽

2014 ◽

Vol 56 (5) ◽

pp. 544-549 ◽

Cited By ~ 6

Author(s):

M. A. Motaleb ◽

M. El-Tawoosy ◽

S. B. Mohamed ◽

I. H. Borei ◽

H. M. Ghanem ◽

...

Keyword(s):

Bacterial Infection ◽

Biological Evaluation ◽

Experimental Animals

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Synthesis, structure, solution behavior, reactivity and biological evaluation of oxidovanadium(iv/v) thiosemicarbazone complexes

Dalton Transactions ◽

10.1039/c8dt01668b ◽

2018 ◽

Vol 47 (33) ◽

pp. 11358-11374 ◽

Cited By ~ 14

Author(s):

Saswati Saswati ◽

Pedro Adão ◽

Sudarshana Majumder ◽

Subhashree P. Dash ◽

Satabdi Roy ◽

...

Keyword(s):

Biological Evaluation ◽

Solution Behavior ◽

Structure Solution ◽

Thiosemicarbazone Complexes

Synthesis, structure and reactivity ofv(iv/v) complexes involving DMSO assisted methylation of thiosemicarbazone.

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Synthesis and Biological Evaluation of Novel Zn(II) and Cd(II) Schiff Base Complexes as Antimicrobial, Antifungal, and Antioxidant Agents

Bioinorganic Chemistry and Applications ◽

10.1155/2020/8866382 ◽

2020 ◽

Vol 2020 ◽

pp. 1-17

Author(s):

Mutlaq S. Aljahdali ◽

Ahmed A. El-Sherif

Keyword(s):

Schiff Base ◽

Formation Constants ◽

Docking Studies ◽

Biological Evaluation ◽

Schiff Base Complexes ◽

Significant Activity ◽

E Coli ◽

Antioxidant Agents ◽

Thiosemicarbazone Complexes ◽

Elemental Analyses

(E)-N,N-Dimethyl-2-((E-1-(2-(p-tolyl)hydrazono)propan-2-ylidene)hydrazine-1-carbothioamide (DMPTHP) and their Zn(II) and Cd(II) complexes have been synthesized and characterized. Different tools of analysis such as elemental analyses, IR, mass spectra, and 1H-NMR measurements were used to elucidate the structure of the synthesized compounds. According to these spectral results, the DMPTHP ligand behaved as a mononegatively charged tridentate anion. Modeling and docking studies were investigated and discussed. Novel Schiff base (DMPTHP) ligand protonation constants and their formation constants with Cd(II) and Zn(II) ions were measured in 50% DMSO solution at 15°C, 25°C, and 35°C at I = 0.1 mol·dm−3 NaNO3. The solution speciation of different species was measured in accordance with pH. Calculation and discussion of the thermodynamic parameters were achieved. Both log K1 and –ΔH1, for M(II)-thiosemicarbazone complexes were found to be somewhat larger than log K2 and –ΔH2, demonstrating a shift in the dentate character of DMPTHP from tridentate in 1 : 1 chelates to bidentate in 1 : 2; M : L chelates and steric hindrance were generated by addition of the 2nd molecule. The compounds prepared have significant activity as antioxidants, similar to ascorbic acid. It is hoped that the results will be beneficial to antimicrobial agent chemistry. The formed compounds acted as a potent antibacterial agent. Molecular docking studies were investigated and have proved that DMPTHP as antibacterial agents act on highly resistant strains of E. coli and also as an anticancer agent.

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