Zn(ii) and Cu(ii) complexes containing bioactive O,O-chelated ligands: homoleptic and heteroleptic metal-based biomolecules

2015 ◽  
Vol 44 (20) ◽  
pp. 9321-9334 ◽  
Author(s):  
Barbara Sanz Mendiguchia ◽  
Iolinda Aiello ◽  
Alessandra Crispini
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Spectroscopic Properties ◽  
Delivery Systems ◽  
Biologically Active ◽  
Donor Ligands ◽  
Diagnostic Agents

Zn(ii) or Cu(ii) highly stable complexes with chelated O,O-donor ligands from natural extractions give rise to drug delivery systems, new biologically active complexes and potential diagnostic agents due to their intrinsic spectroscopic properties.

Advances in the use of MOFs for Cancer Diagnosis and Treatment: An Overview

2020 ◽  
Vol 26 (33) ◽  
pp. 4174-4184
Author(s):  
Marina P. Abuçafy ◽  
Bruna L. da Silva ◽  
João A. Oshiro-Junior ◽  
Eloisa B. Manaia ◽  
Bruna G. Chiari-Andréo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Rational Design ◽  
Gas Adsorption ◽  
Drug Loading ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Academic Community ◽  
Anticancer Drug Delivery ◽  
Diagnostic Agents

Nanoparticles as drug delivery systems and diagnostic agents have gained much attention in recent years, especially for cancer treatment. Nanocarriers improve the therapeutic efficiency and bioavailability of antitumor drugs, besides providing preferential accumulation at the target site. Among different types of nanocarriers for drug delivery assays, metal-organic frameworks (MOFs) have attracted increasing interest in the academic community. MOFs are an emerging class of coordination polymers constructed of metal nodes or clusters and organic linkers that show the capacity to combine a porous structure with high drug loading through distinct kinds of interactions, overcoming the limitations of traditional drug carriers explored up to date. Despite the rational design and synthesis of MOFs, structural aspects and some applications of these materials like gas adsorption have already been comprehensively described in recent years; it is time to demonstrate their potential applications in biomedicine. In this context, MOFs can be used as drug delivery systems and theranostic platforms due to their ability to release drugs and accommodate imaging agents. This review describes the intrinsic characteristics of nanocarriers used in cancer therapy and highlights the latest advances in MOFs as anticancer drug delivery systems and diagnostic agents.

Nanotechnology: Revolutionizing the Science of Drug Delivery

2019 ◽  
Vol 24 (43) ◽  
pp. 5086-5107 ◽  
Author(s):  
Mohini Mishra ◽  
Pramod Kumar ◽  
Jitendra Singh Rajawat ◽  
Ruchi Malik ◽  
Gitanjali Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Structural Features ◽  
Delivery Systems ◽  
The Novel ◽  
Drug Delivery Vehicles ◽  
Conventional Drug ◽  
Diagnostic Agents ◽  
Pros And Cons ◽  
Novel Drug

Growing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery systems describing their structural features along with the pros and cons associated with them and the nanodrugs that made a move to the clinical practice. It also focuses on the need of the novel drug delivery systems and the challenges faced by the conventional drug delivery systems.

scholarly journals Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1329 ◽  
Author(s):  
Febrina Sandra ◽  
Nisar Ul Khaliq ◽  
Anwar Sunna ◽  
Andrew Care
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Future Directions ◽  
Cancer Nanomedicine ◽  
Diagnostic Agents ◽  
Poor Understanding ◽  
Potential Alternative ◽  
Clinical Potential

In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio–nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.

scholarly journals Strategies in poorly soluble drug delivery systems

2019 ◽  
Vol 73 (1) ◽  
pp. 81
Author(s):  
Magdalena Szaniawska
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Point Of View ◽  
Water Soluble ◽  
Biologically Active ◽  
Water Soluble Drugs ◽  
Medicinal Substances ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

<p>The form of the active drug administered to patients is important as far as effectiveness of the disease therapy is concerned. From this point of view modifications of medicinal substances are searched for that the obtained compounds have the best physicochemical and pharmacodynamic properties. Pharmaceutical companies allocate significant funds for this type of research. The key property that needs to be improved is the solubility of biologically active substances. This is related to the fact that over 40% of drugs available on the pharmaceutical market are characterized by low solubility in water.</p><p>Thus, the paper describes the most important strategies used in the poorly soluble drug delivery systems, e.g. physical and chemical modifications, formulation based, modification of partition coefficient and lipid systems. The authors discussed various techniques used to enhance solubility of poorly water soluble drugs with their advantages and limitations.</p>

scholarly journals New drug delivery strategies targeting GnRH receptor in breast and other cancers

2021 ◽  
Author(s):  
Hany Sadek Ayoub Ghaly ◽  
Pegah Varamini
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gnrh Receptor ◽  
Diagnostic Agents ◽  
Specific Organ ◽  
Abnormal Cells ◽  
Potential Strategy

Cancer is the uncontrolled division of abnormal cells in a specific organ. Globally, about 1 in 6 deaths is due to cancer. Despite the plethora of research being undertaken worldwide to find a cure for cancer, it remains a significant challenge. Cancer targeting via agents designed to interfere with some specifically or highly expressed molecules in cancer cells has been a shift in the treatment of various forms of cancers. The development of drug delivery systems, specifically to cancer cells, is a common approach that succeeded in increasing the efficacy and reducing the side effects of different anticancer agents. Gonadotropin-releasing hormone (GnRH) is a naturally occurring hormone with receptors overexpressed in many types of cancers related or unrelated to the reproductive system. Several drug delivery systems were developed using GnRH derivatives as targeting agents. In this review, we first discuss the role of GnRH and its receptors in cancer. Then, we provide a detailed insight into different delivery systems developed using GnRH derivatives as targeting agents in various types of GnRH receptor overexpressing cancers. Some promising findings from these studies indicate that GnRH receptor targeting is a potential strategy to efficiently guide anticancer therapeutics, diagnostic agents, and nucleic acids directly to cancer cells. Lastly, some limitations of the current research and suggestions for more successful outcomes in clinical trials of these delivery systems are highlighted.

Enhanced Transmucosal Transport Using Osmolyte-Mediated Fluid-Matrix Interaction

2011 ◽  
Author(s):  
Ka Yaw Teo ◽  
Basma Ibrahim ◽  
Seungman Park ◽  
Yeo Yoon ◽  
Bumsoo Han
Keyword(s):  
Drug Delivery ◽  
Oral Cavity ◽  
Surface Chemistry ◽  
Nasal Cavity ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Delivery Systems ◽  
Matrix Interaction ◽  
Diagnostic Agents

Various drug delivery systems are developed to deliver therapeutic and diagnostic agents to tissues covered with mucus, such as airways, nasal cavity, or oral cavity [1]. However, the mucus, which present for protection of the tissues, significantly hinders the transport of these agents and ultimately mitigates their efficacy [2]. Several studies have been performed to improve the transmucosal transport by studying the transport rates of polymeric nanoparticles with various sizes and surface chemistry [3–5]. However, drug delivery systems with improved transmucosal transport capability are still highly desired.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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