Efficient synthesis of a statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis

2015 ◽  
Vol 5 (8) ◽  
pp. 4048-4054 ◽  
Author(s):  
Xue-Cheng Jiao ◽  
Jiang Pan ◽  
Guo-Chao Xu ◽  
Xu-Dong Kong ◽  
Qi Chen ◽  
...  
Keyword(s):  
High Activity ◽  
Lactobacillus Brevis ◽  
Space Time ◽  
High Tolerance ◽  
Efficient Synthesis ◽  
High Space ◽  
Space Time Yield

A novel 2-deoxyribose-5-phosphate aldolase (LbDERA) was identified from Lactobacillus brevis, with high activity, excellent thermostability and high tolerance against aldehyde substrates.

scholarly journals Efficient synthesis of Ibrutinib chiral intermediate in high space-time yield by recombinant E. coli co-expressing alcohol dehydrogenase and glucose dehydrogenase

RSC Advances ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 2325-2331 ◽  
Author(s):  
Yitong Chen ◽  
Baodi Ma ◽  
Songshuang Cao ◽  
Xiaomei Wu ◽  
Yi Xu
Keyword(s):  
Alcohol Dehydrogenase ◽  
Glucose Dehydrogenase ◽  
Space Time ◽  
Optically Active ◽  
Efficient Synthesis ◽  
E Coli ◽  
Efficient Process ◽  
High Space ◽  
Space Time Yield

A simple and efficient process for the synthesis of optically active (S)-N-boc-3-hydroxy piperidine was developed using the “designer cells” co-expressing alcohol dehydrogenase and glucose dehydrogenase.

Synthesis of pure and uniform nano-sized TS-1 crystal with high titanium content and high space-time yield

2021 ◽  
Author(s):  
Lejian Zhang ◽  
Xiaoxiao Zhu ◽  
Xinping Wang ◽  
Chuan Shi
Keyword(s):  
Selective Oxidation ◽  
Cost Efficiency ◽  
Environmental Issues ◽  
Titanium Content ◽  
Space Time ◽  
Titanium Silicalite ◽  
Oxidation Reactions ◽  
High Space ◽  
Space Time Yield ◽  
Selective Oxidation Reactions

Anatase-free titanium silicalite-1 (TS-1) zeolite with high framework titanium content is highly required for catalysing selective oxidation reactions, while its synthesis generally suffers from cost, efficiency and environmental issues. Herein,...

Highly Efficient Synthesis of (R)-3-Quinuclidinol in a Space–Time Yield of 916 g L–1 d–1 Using a New Bacterial Reductase ArQR

2013 ◽  
Vol 15 (19) ◽  
pp. 4917-4919 ◽  
Author(s):  
Wen-Xia Zhang ◽  
Guo-Chao Xu ◽  
Lei Huang ◽  
Jiang Pan ◽  
Hui-Lei Yu ◽  
...  
Keyword(s):  
Space Time ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Space Time Yield

ChemInform Abstract: Efficient Synthesis of an ε-Hydroxy Ester (II) in a Space-Time Yield of 1580 gL-1d-1by a Newly Identified Reductase RhCR.

ChemInform ◽  
2015 ◽  
Vol 46 (18) ◽  
pp. no-no
Author(s):  
Rui-Jie Chen ◽  
Gao-Wei Zheng ◽  
Yan Ni ◽  
Bu-Bing Zeng ◽  
Jian-He Xu
Keyword(s):  
Space Time ◽  
Hydroxy Ester ◽  
Efficient Synthesis ◽  
Space Time Yield

scholarly journals Production of cellulase by Microbulbifer hydrolyticus through co-fermentation of glucose and xylose from lignocellulose

BioResources ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. 8689-8695
Author(s):  
Huan Liu ◽  
Xiaolan Huang ◽  
Qi Xiao ◽  
Yue Yu ◽  
Li Deng ◽  
...  
Keyword(s):  
Growth Rate ◽  
Marine Bacterium ◽  
Cellulase Activity ◽  
Cellulase Production ◽  
Space Time ◽  
Processing Industry ◽  
Distiller's Grains ◽  
High Space ◽  
Space Time Yield ◽  
Fast Growth Rate

Cellulase is a compound enzyme that catalyzes cellulose into monosaccharides or oligosaccharides. Large amounts of cellulase are needed with the development of the lignocellulose processing industry, which necessitates faster methods to produce cellulase. In this work, the marine bacterium Microbulbifer hydrolyticus IRE-31-192 was selected to produce cellulase, due to its fast growth rate and short high space-time yield. Co-fermentation of glucose and xylose to produce cellulase was investigated on the basis of previous work. When the ratio of glucose/xylose was 2:1 (w/w), 294 U/L cellulase activity with highest space-time yield of 12.2 U/L h was obtained. The hydrolytic liquid of lignocellulose prepared from dried distiller’s grains with solubles (DDGS) with the similar ratio of glucose/xylose was used as medium to produce cellulase. The efficiency of cellulase production from processed and unprocessed hydrolysates of DDGS was compared. Unprocessed hydrolysates were more beneficial for the production of cellulase, such that its activity was 261 U/L with a space-time yield of 14.5 U/L h. Thus, commonly used pure glucose and xylose could be replaced by hydrolysates of DDGS, and marine bacteria has potential application for cellulase production.

Efficient synthesis of an ε-hydroxy ester in a space–time yield of 1580gL−1d−1 by a newly identified reductase RhCR

2014 ◽  
Vol 25 (23) ◽  
pp. 1501-1504 ◽  
Author(s):  
Rui-Jie Chen ◽  
Gao-Wei Zheng ◽  
Yan Ni ◽  
Bu-Bing Zeng ◽  
Jian-He Xu
Keyword(s):  
Space Time ◽  
Hydroxy Ester ◽  
Efficient Synthesis ◽  
Space Time Yield
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