Diarylferrocene tweezers for cation binding

2015 ◽  
Vol 17 (37) ◽  
pp. 23917-23923 ◽  
Author(s):  
Carlos F. R. A. C. Lima ◽  
Ana M. Fernandes ◽  
André Melo ◽  
Luís M. Gonçalves ◽  
Artur M. S. Silva ◽  
...  
Keyword(s):  
Gas Phase ◽  
Molecular Shape ◽  
Cation Binding ◽  
Molecular Tweezers ◽  
Strong Binding ◽  
Torsional Potentials

Diarylferrocenes can act as molecular tweezers of cations. Their unique molecular shape and low torsional potentials allow for strong binding of small cations in the gas phase.

scholarly journals Electrostatically Tuning the Photodissociation of the Irgacure 2959 Photoinitiator in the Gas Phase by Cation Binding

2021 ◽  
Vol 143 (5) ◽  
pp. 2331-2339
Author(s):  
Samuel J. P. Marlton ◽  
Benjamin I. McKinnon ◽  
Nicholas S. Hill ◽  
Michelle L. Coote ◽  
Adam J. Trevitt
Keyword(s):  
Gas Phase ◽  
Cation Binding

Metal Cation Binding to Gas-Phase Pentaalanine: Divalent Ions Restructure the Complex

2012 ◽  
Vol 117 (6) ◽  
pp. 1094-1101 ◽  
Author(s):  
Robert C. Dunbar ◽  
Jeffrey D. Steill ◽  
Nicolas C. Polfer ◽  
Jos Oomens
Keyword(s):  
Gas Phase ◽  
Metal Cation ◽  
Cation Binding ◽  
Divalent Ions

scholarly journals DNA and RNA Telomeric G-Quadruplexes: What Topology Features Can be Inferred from Ion Mobility Mass Spectrometry?

2019 ◽  
Author(s):  
Valentina D’Atri ◽  
Valerie Gabelica
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Native Mass Spectrometry ◽  
Cation Binding ◽  
Telomeric Dna ◽  
Dna And Rna ◽  
G Quadruplex ◽  
Multiple Structures

Maintenance of the telomeres is key to chromosome integrity and cell proliferation. The G-quadruplex structures formed by telomeric DNA and RNA (TTAGGG and UUAGGG repeats, respectively) are key to this process. However, because these sequences are particularly polymorphic, solving high-resolution structures is not always possible, and there is a need for new methodologies to characterize the multiple structures coexisting in solution. In this context, we evaluated whether ion mobility spectrometry coupled to native mass spectrometry could help separate and assign the G-quadruplex topologies. We explored the circular dichroism spectra, multimer formation, cation binding, and ion mobility spectra of several 4-repeat and 8-repeat telomeric DNA and RNA sequences, both in NH<sub>4</sub><sup>+</sup> and in K<sup>+</sup>. In 1 mM K<sup>+</sup> and 100 mM trimethylammonium acetate, all RNAs fold intramolecularly (no multimer). In 8-repeat sequences, the subunits are not independent: in DNA the first subunit disfavors the folding of the second one, whereas in RNA the two subunits fold cooperatively via cation-mediated stacking. Ion mobility spectrometry shows that gas-phase structures keep a memory of the solution ones, but not identical. At the native charge states, the loops can rearrange in a variety of ways (unless they are constrained by pre-formed hydrogen bonds), thereby wrapping the core and masking the strand arrangements. Our study highlights that, to progress towards structural assignment from IM-MS experiments, deeper understanding of the solution-to-gas-phase rearrangement mechanisms is warranted. <br>

Synthesis and cation-binding studies of gold(i) complexes bearing oligoether isocyanide ligands with ester and amide as linkers

2016 ◽  
Vol 45 (1) ◽  
pp. 300-306 ◽  
Author(s):  
Franky Ka-Wah Hau ◽  
Vivian Wing-Wah Yam
Keyword(s):  
Binding Affinity ◽  
Cation Binding ◽  
Low Energy ◽  
Binding Studies ◽  
Isocyanide Ligands ◽  
Energy Emission ◽  
Strong Binding

Bis(alkynyl)calix[4]arene gold(i) isocyanide complexes with amide linkers show strong binding affinity towards Al3+, which turns on the low-energy emission associated with the presence of Au(i)⋯Au(i) interactions.

Intramolecularly enhanced molecular tweezers with unusually strong binding for aromatic guests in unfavorable solvents

2018 ◽  
Vol 16 (21) ◽  
pp. 3885-3888
Author(s):  
Xiaoyu Xing ◽  
Yan Zhao
Keyword(s):  
Molecular Tweezers ◽  
Nonpolar Solvents ◽  
Aromatic Interactions ◽  
Solvophobic Effect ◽  
Strong Binding

Molecular tweezers using aromatic interactions for binding normally work best in polar instead of nonpolar solvents due to the strong solvophobic effect in the binding.

scholarly journals DNA and RNA Telomeric G-Quadruplexes: What Topology Features Can be Inferred from Ion Mobility Mass Spectrometry?

2019 ◽  
Author(s):  
Valentina D’Atri ◽  
Valerie Gabelica
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Native Mass Spectrometry ◽  
Cation Binding ◽  
Telomeric Dna ◽  
Dna And Rna ◽  
G Quadruplex ◽  
Multiple Structures

Maintenance of the telomeres is key to chromosome integrity and cell proliferation. The G-quadruplex structures formed by telomeric DNA and RNA (TTAGGG and UUAGGG repeats, respectively) are key to this process. However, because these sequences are particularly polymorphic, solving high-resolution structures is not always possible, and there is a need for new methodologies to characterize the multiple structures coexisting in solution. In this context, we evaluated whether ion mobility spectrometry coupled to native mass spectrometry could help separate and assign the G-quadruplex topologies. We explored the circular dichroism spectra, multimer formation, cation binding, and ion mobility spectra of several 4-repeat and 8-repeat telomeric DNA and RNA sequences, both in NH<sub>4</sub><sup>+</sup> and in K<sup>+</sup>. In 1 mM K<sup>+</sup> and 100 mM trimethylammonium acetate, all RNAs fold intramolecularly (no multimer). In 8-repeat sequences, the subunits are not independent: in DNA the first subunit disfavors the folding of the second one, whereas in RNA the two subunits fold cooperatively via cation-mediated stacking. Ion mobility spectrometry shows that gas-phase structures keep a memory of the solution ones, but not identical. At the native charge states, the loops can rearrange in a variety of ways (unless they are constrained by pre-formed hydrogen bonds), thereby wrapping the core and masking the strand arrangements. Our study highlights that, to progress towards structural assignment from IM-MS experiments, deeper understanding of the solution-to-gas-phase rearrangement mechanisms is warranted. <br>

Sign in / Sign up

Export Citation Format

Share Document