pH-responsive ion transport in polyelectrolyte multilayers of poly(diallyldimethylammonium chloride) (PDADMAC) and poly(4-styrenesulfonic acid-co-maleic acid) (PSS-MA) bearing strong- and weak anionic groups

2015 ◽  
Vol 17 (44) ◽  
pp. 29935-29948 ◽  
Author(s):  
Eliana Maza ◽  
Jimena S. Tuninetti ◽  
Nikolaos Politakos ◽  
Wolfgang Knoll ◽  
Sergio Moya ◽  
...  
Keyword(s):  
Ion Transport ◽  
Transport Properties ◽  
Maleic Acid ◽  
Ionic Transport ◽  
Polyelectrolyte Multilayers ◽  
Ph Responsive ◽  
Diallyldimethylammonium Chloride ◽  
Ph Dependent ◽  
The Creation ◽  
Anionic Groups

We describe the creation of interfacial architectures displaying pH-dependent ionic transport properties which until now have not been observed in polyelectrolyte multilayers.

scholarly journals Continuous Electrodeionization: Production of High-Purity Water without Regeneration Chemicals

1998 ◽  
Vol 7 (3) ◽  
pp. 26-29
Author(s):  
Felice DiMascio ◽  
Jonathan Wood ◽  
James M. Fenton
Keyword(s):  
Ion Transport ◽  
Transport Properties ◽  
High Purity ◽  
Scale Up ◽  
Electrical Potential ◽  
Ionic Transport ◽  
Capacitive Deionization ◽  
Active Media ◽  
Primary Scale

Electrochemical deionization (EDI), also called electrodeionization, is a process that removes ionizable species from liquids using ionically active media and an electrical potential to influence ionic transport. Electrodeionization processes can be batch or continuous. Continuous Electrodeionization (CEDI) is an electrodeionization process where the ion transport properties of the active media are the primary scale-up parameters. There are also batch electrodeionization processes, such as capacitive deionization, where the ion capacity properties of the active media are the primary sizing parameters.

scholarly journals pH-responsive antibodies for therapeutic applications

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Tomasz Klaus ◽  
Sameer Deshmukh
Keyword(s):  
Drug Delivery ◽  
Treatment Outcome ◽  
Tumor Microenvironment ◽  
Dependent Manner ◽  
Therapeutic Antibodies ◽  
Ph Responsive ◽  
Biologic Drugs ◽  
Car T ◽  
Ph Dependent ◽  
The Brain

AbstractTherapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the approaches that are increasingly explored in this field are pH-responsive antibodies capable of binding target antigens in a pH-dependent manner. We reviewed suitability and examples of these antibodies that are functionally modulated by the tumor microenvironment. Provided in this review is an update about antigens targeted by pH-responsive, sweeping, and recycling antibodies. Applicability of the pH-responsive antibodies in the engineering of chimeric antigen receptor T-cells (CAR-T) and in improving drug delivery to the brain by the enhanced crossing of the blood–brain barrier is also discussed. The pH-responsive antibodies possess strong treatment potential. They emerge as next-generation programmable engineered biologic drugs that are active only within the targeted biological space. Thus, they are valuable in targeting acidified tumor microenvironment because of improved spatial persistence and reduced on-target off-tumor toxicities. We predict that the programmable pH-dependent antibodies become powerful tools in therapies of cancer.

Ion transport properties of ionic liquid based gel electrolytes

2012 ◽  
Vol 60 ◽  
pp. 366-374 ◽  
Author(s):  
S.S. Sekhon ◽  
D.P. Kaur ◽  
J.-S. Park ◽  
K. Yamada
Keyword(s):  
Ionic Liquid ◽  
Ion Transport ◽  
Transport Properties ◽  
Gel Electrolytes

Design, synthesis and membrane ion transport properties of cystine- and serine-based cyclo -4-oxa-heptane-1,7-bisamides

2002 ◽  
Vol 43 (29) ◽  
pp. 5145-5147 ◽  
Author(s):  
Darshan Ranganathan ◽  
Manoj P Samant ◽  
R Nagaraj ◽  
E Bikshapathy
Keyword(s):  
Ion Transport ◽  
Transport Properties ◽  
Design Synthesis ◽  
Membrane Ion Transport

Glycan chip based on structure switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans

2021 ◽  
Author(s):  
Hye Ryoung Heo ◽  
Kye Il Joo ◽  
Jeong Hyun Seo ◽  
Chang Sup Kim ◽  
Hyung Joon Cha
Keyword(s):  
Breast Cancer Cells ◽  
Enzymatic Reactions ◽  
Dependent Manner ◽  
Ph Responsive ◽  
Quantitative Analyses ◽  
Ph Dependent ◽  
Complex Glycans ◽  
On Chip ◽  
Complex Glycan ◽  
Mcf 7

Abstract On-chip glycan biosynthesis is an effective strategy for preparing useful complex glycan sources and for preparing glycan-involved applications simultaneously. However, current methods have some limitations when analyzing biosynthesized glycans and optimizing enzymatic reactions, which could result in undefined glycan structures on a surface, leading to unequal and unreliable results. In this work, a novel glycan chip was developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chip surfaces in a pH-dependent manner. On-chip enzymatic glycosylations were optimized for uniform biosynthesis of cancer-associated Globo H hexasaccharide and its related complex glycans through stepwise quantitative analyses of isolated products from the surface. Successful interaction analyses of the anti-Globo H antibody and MCF-7 breast cancer cells with on-chip biosynthesized Globo H-related glycans demonstrated the feasibility of the structure-switchable DNA linker-based glycan chip platform for on-chip complex glycan biosynthesis and glycan-involved applications.

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