scholarly journals Glycosaminoglycans are potential pharmacological targets for classic DNA minor groove binder drugs berenil and pentamidine

2015 ◽  
Vol 17 (38) ◽  
pp. 24560-24565 ◽  
Author(s):  
Ferenc Zsila
Keyword(s):  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Pharmacological Targets ◽  
Groove Binders ◽  
Dna Minor Groove Binder

It is shown that the antiprotozoal drugs berenil and pentamidine, conventional minor groove binders of DNA, form non-covalent complexes with polyanionic glycosaminoglycans.

scholarly journals Trabectedin – the DNA minor groove binder

2015 ◽  
Vol 2 (2) ◽  
pp. 41
Author(s):  
G. A. Belitsky ◽  
K. I. Kirsanov ◽  
E. A. Lesovaya ◽  
M. G. Yakubovskaya
Keyword(s):  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder

scholarly journals Fluorescence-Labeled Bis-benzamidines as Fluorogenic DNA Minor-Groove Binders: Photophysics and Binding Dynamics

2014 ◽  
Vol 21 (4) ◽  
pp. 1609-1619 ◽  
Author(s):  
Jorge Bordello ◽  
Mateo I. Sánchez ◽  
M. Eugenio Vázquez ◽  
José L. Mascareñas ◽  
Wajih Al-Soufi ◽  
...  
Keyword(s):  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

DNA minor groove binders as potential antitumor and antimicrobial agents

2004 ◽  
Vol 24 (4) ◽  
pp. 475-528 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Andrea Bovero ◽  
Francesca Fruttarolo ◽  
Delia Preti ◽  
Mojgan Aghazadeh Tabrizi ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Minor Groove ◽  
Dna Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders ◽  
Potential Antitumor

Inhibition of the in vitro integration of moloney murine leukemia virus DNA by the DNA minor groove binder netropsin

1994 ◽  
Vol 47 (10) ◽  
pp. 1821-1826 ◽  
Author(s):  
Sandrine Carteau ◽  
Jean Francois Mouscadet ◽  
Hélène Goulaouic ◽  
Frédéric Subra ◽  
Christian Auclair
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Minor Groove ◽  
Moloney Murine Leukemia Virus ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Murine Leukemia ◽  
Dna Minor Groove Binder

Design, Synthesis, and Biological Activity of Hybrid Compounds between Uramustine and DNA Minor Groove Binder Distamycin A

2002 ◽  
Vol 45 (17) ◽  
pp. 3630-3638 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Romeo Romagnoli ◽  
Antonio Entrena Guadix ◽  
Maria Josè Pineda de las Infantas ◽  
Miguel Angel Gallo ◽  
...  
Keyword(s):  
Biological Activity ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Design Synthesis ◽  
Distamycin A ◽  
Dna Minor Groove ◽  
Hybrid Compounds ◽  
Dna Minor Groove Binder

scholarly journals Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding

2014 ◽  
Vol 10 (10) ◽  
pp. 2724-2734 ◽  
Author(s):  
Jie Zhou ◽  
Vu Le ◽  
Dimpy Kalia ◽  
Shizuka Nakayama ◽  
Clinton Mikek ◽  
...  
Keyword(s):  
Dissociation Constant ◽  
Dissociation Constants ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
G Quadruplex ◽  
Dna Minor Groove Binder

Diminazene or berenil is known to be an AT-rich DNA minor groove binder with micromolar dissociation constant. Here, we show that DMZ binds to G-quadruplexes withKdas low as 1 nM.

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