Photosensitized samarium(iii) and erbium(iii) complexes of planar N,N-donor heterocyclic bases: crystal structures and evaluation of biological activity

CrystEngComm ◽  
2016 ◽  
Vol 18 (23) ◽  
pp. 4313-4322 ◽  
Author(s):  
Srikanth Dasari ◽  
Zafar Abbas ◽  
Priyaranjan Kumar ◽  
Ashis K. Patra
Keyword(s):  
Dna Damage ◽  
Biological Activity ◽  
Crystal Structures ◽  
Luminescence Properties ◽  
Heterocyclic Bases

A series of Sm(iii) and Er(iii) complexes of N,N-donor heterocyclic bases were studied for their crystal structures, luminescence properties, binding with biomolecules and photo-induced DNA damage activity.

scholarly journals In Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverages

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2198
Author(s):  
Marcos Mateo-Fernández ◽  
Fernando Valenzuela-Gómez ◽  
Rafael Font ◽  
Mercedes Del Río-Celestino ◽  
Tania Merinas-Amo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Drosophila Melanogaster ◽  
Biological Activity ◽  
Biological Effects ◽  
Methylation Status ◽  
Repetitive Sequences ◽  
Energy Drinks ◽  
Red Bull

Taurine is one of the main ingredients used in energy drinks which are highly consumed in adolescents for their sugary taste and stimulating effect. With energy drinks becoming a worldwide phenomenon, the biological effects of these beverages must be evaluated in order to fully comprehend the potential impact of these products on the health due to the fact nutrition is closely related to science since the population consumes food to prevent certain diseases. Therefore, the aim of this study was to evaluate the biological effects of taurine, glucose, classic Red Bull® and sugar-free Red Bull® in order to check the food safety and the nutraceutical potential of these compounds, characterising different endpoints: (i) Toxicology, antitoxicology, genotoxicology and life expectancy assays were performed in the Drosophila melanogaster model organism; (ii) The in vitro chemopreventive activity of testing compounds was determined by assessing their cytotoxicity, the proapoptotic DNA-damage capability to induce internucleosomal fragmentation, the strand breaks activity and the modulator role on the methylation status of genomic repetitive sequences of HL-60 promyelocytic cells. Whereas none tested compounds showed toxic or genotoxic effect, all tested compounds exerted antitoxic and antigenotoxic activity in Drosophila. Glucose, classic Red Bull® and sugar-free Red Bull® were cytotoxic in HL-60 cell line. Classic Red Bull® induced DNA internucleosomal fragmentation although none of them exhibited DNA damage on human leukaemia cells. In conclusion, the tested compounds are safe on Drosophila melanogaster and classic Red Bull® could overall possess nutraceutical potential in the in vivo and in vitro model used in this study. Besides, taurine could holistically be one of the bioactive compounds responsible for the biological activity of classic Red Bull®.

Synthesis, crystal structures, and biological activity of oxovanadium(V) complexes with similar tridentate hydrazone ligands

2014 ◽  
Vol 67 (10) ◽  
pp. 1760-1770 ◽  
Author(s):  
Gui-Hua Sheng ◽  
Xiao Han ◽  
Zhonglu You ◽  
Hai-Hua Li ◽  
Hai-Liang Zhu
Keyword(s):  
Biological Activity ◽  
Crystal Structures ◽  
Hydrazone Ligands

scholarly journals Structural basis of HMCES interactions with DNA reveals multivalent substrate recognition

2019 ◽  
Author(s):  
Levon Halabelian ◽  
Mani Ravichandran ◽  
Yanjun Li ◽  
Hong Zheng ◽  
L. Aravind ◽  
...  
Keyword(s):  
Dna Damage ◽  
Crystal Structures ◽  
Genome Instability ◽  
Substrate Recognition ◽  
Catalytic Triad ◽  
Structural Basis ◽  
Replication Forks ◽  
Abasic Sites ◽  
Stalled Replication Forks ◽  
Gapped Dna

ABSTRACTHMCES can covalently crosslink to abasic sites in single-stranded DNA at stalled replication forks to prevent genome instability. Here, we report crystal structures of the HMCES SRAP domain in complex with DNA-damage substrates, revealing interactions with both single-stranded and duplex segments of 3’ overhang DNA. HMCES may also bind gapped DNA and 5’ overhang structures to align single stranded abasic sites for crosslinking to the conserved Cys2 of its catalytic triad.

Synthesis, crystal structures and luminescence properties of two metal carboxyphosphonates

2017 ◽  
Vol 249 ◽  
pp. 136-140 ◽  
Author(s):  
Chaonan Wang ◽  
Pingjing Feng ◽  
Jintang Li ◽  
Xuetao Luo
Keyword(s):  
Crystal Structures ◽  
Luminescence Properties

Luminescent EuIII and TbIII bimetallic complexes of N,N′-heterocyclic bases and tolfenamic acid: structures, photophysical aspects and biological activity

2020 ◽  
Vol 44 (36) ◽  
pp. 15685-15697
Author(s):  
Zafar Abbas ◽  
Prerana Singh ◽  
Srikanth Dasari ◽  
Sri Sivakumar ◽  
Ashis K. Patra
Keyword(s):  
Biological Activity ◽  
Cellular Imaging ◽  
Tolfenamic Acid ◽  
Bimetallic Complexes ◽  
Bridging Ligands ◽  
Imaging Capability ◽  
Heterocyclic Bases

The isostructural bimetallic luminescent EuIII and TbIII dimers containing N,N′-heterocyclic bases and tolfenamic acid as a bridging ligands were evaluated for their structures, cellular imaging capability and photocytotoxicity.

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