Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis

2015 ◽  
Vol 51 (92) ◽  
pp. 16450-16467 ◽  
Author(s):  
Amit Kumar Chattopadhyay ◽  
Stephen Hanessian
Keyword(s):  
Total Synthesis ◽  
Building Blocks ◽  
Alkaloid Synthesis ◽  
Cyclic Enaminones

Among many other strategies, the enaminone approach is an important strategy to construct and diversify the azacyclic core in various alkaloids syntheses. In this brief review we discuss the application of cyclic enaminones as building blocks, as well as potential intermediates in the total synthesis of selected alkaloids.

scholarly journals gem-Dibromocyclopropanes and enzymatically derived cis-1,2-dihydrocatechols as building blocks in alkaloid synthesis

2011 ◽  
Vol 84 (6) ◽  
pp. 1329-1339 ◽  
Author(s):  
Martin G. Banwell ◽  
Nadia Yuqian Gao ◽  
Xinghua Ma ◽  
Laurent Petit ◽  
Lorenzo V. White ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Building Blocks ◽  
Alkaloid Synthesis

The application of the title building blocks, the 6,6-dibromobicyclo[3.1.0]hexanes and the cis-1,2-dihydrocatechols, to the total synthesis of crinine and lycorinine alkaloids is described.

scholarly journals Non-Enzymatic Desymmetrization Reactions in Aqueous Media

Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 720
Author(s):  
Satomi Niwayama
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Functional Groups ◽  
Organic Compounds ◽  
Recent Progress ◽  
Aqueous Media ◽  
Building Blocks ◽  
Organic Reactions ◽  
Environmentally Benign ◽  
Enzymatic Desymmetrization

Symmetric organic compounds are generally obtained inexpensively, and therefore they can be attractive building blocks for the total synthesis of various pharmaceuticals and natural products. The drawback is that discriminating the identical functional groups in the symmetric compounds is difficult. Water is the most environmentally benign and inexpensive solvent. However, successful organic reactions in water are rather limited due to the hydrophobicity of organic compounds in general. Therefore, desymmetrization reactions in aqueous media are expected to offer versatile strategies for the synthesis of a variety of significant organic compounds. This review focuses on the recent progress of desymmetrization reactions of symmetric organic compounds in aqueous media without utilizing enzymes.

Total Synthesis of Woodrosin I. Part 1. Preparation of the Building Blocks and Evaluation of the Glycosylation Strategy.

ChemInform ◽  
2003 ◽  
Vol 34 (18) ◽  
Author(s):  
Alois Fuerstner ◽  
Fabien Jeanjean ◽  
Patrick Razon ◽  
Conny Wirtz ◽  
Richard Mynott
Keyword(s):  
Total Synthesis ◽  
Building Blocks

Stereocontrolled construction of key building blocks for the total synthesis of amphoteronolide B and amphotericin B

1987 ◽  
Vol 109 (7) ◽  
pp. 2205-2208 ◽  
Author(s):  
Kyriacos C. Nicolaou ◽  
R. A. Daines ◽  
J. Uenishi ◽  
W. S. Li ◽  
D. P. Papahatjis ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Amphotericin B ◽  
Building Blocks

ChemInform Abstract: Stereocontrolled Construction of Key Building Blocks for the Total Synthesis of Amphoteronolide B and Amphotericin B.

ChemInform ◽  
1987 ◽  
Vol 18 (33) ◽  
Author(s):  
K. C. NICOLAOU ◽  
R. A. DAINES ◽  
J. UENISHI ◽  
W. S. LI ◽  
D. P. PAPAHATJIS ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Amphotericin B ◽  
Building Blocks
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