Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships

2015 ◽  
Vol 51 (81) ◽  
pp. 15027-15030 ◽  
Author(s):  
Mark B. Richardson ◽  
Shota Torigoe ◽  
Sho Yamasaki ◽  
Spencer J. Williams
Keyword(s):  
Pattern Recognition ◽  
Mycobacterium Tuberculosis ◽  
Total Synthesis ◽  
Pattern Recognition Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Recognition Receptor

Gentiobiosyl diglycerides fromMycobacterium tuberculosisare shown to signal through Mincle; structure–activity relationships reveal analogues with enhanced potency.

scholarly journals Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132692 ◽  
Author(s):  
Anthony Troegeler ◽  
Geanncarlo Lugo-Villarino ◽  
Søren Hansen ◽  
Voahangy Rasolofo ◽  
Maiken Lumby Henriksen ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Mycobacterium Tuberculosis ◽  
Pattern Recognition Receptor ◽  
Recognition Receptor

scholarly journals Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 72
Author(s):  
Lena Trifonov ◽  
Vadim Nudelman ◽  
Michael Zhenin ◽  
Guy Cohen ◽  
Krzysztof Jozwiak ◽  
...  
Keyword(s):  
Immune Response ◽  
Pattern Recognition ◽  
Myocardial Ischemia ◽  
Mouse Model ◽  
Innate Immune Response ◽  
Pattern Recognition Receptor ◽  
Innate Immune ◽  
Microbial Pathogens ◽  
Toll Like Receptors ◽  
Recognition Receptor

TLR4, a member of the toll-like receptors (TLRs) family, serves as a pattern recognition receptor in the innate immune response to different microbial pathogens. [...]

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