Supramolecular inclusion-based molecular integral rigidity: a feasible strategy for controlling the structural connectivity of uranyl polyrotaxane networks

2015 ◽  
Vol 51 (60) ◽  
pp. 11990-11993 ◽  
Author(s):  
Lei Mei ◽  
Lin Wang ◽  
Li-yong Yuan ◽  
Shu-wen An ◽  
Yu-liang Zhao ◽  
...  
Keyword(s):  
Structural Connectivity ◽  
Molecular Integral ◽  
Integration Strategy

The assembly of 2D uranyl–organic rotaxane networks with well-defined channels has been achieved through an integration strategy from jointed pseudorotaxanes.

Mapping efficacious deep brain stimulation for pediatric dystonia

2021 ◽  
pp. 1-11
Author(s):  
Ailish Coblentz ◽  
Gavin J. B. Elias ◽  
Alexandre Boutet ◽  
Jurgen Germann ◽  
Musleh Algarni ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Clinical Outcome ◽  
Brain Stimulation ◽  
Pediatric Patients ◽  
Rating Scale ◽  
Structural Connectivity ◽  
Response To Treatment ◽  
Internal Globus Pallidus ◽  
Probabilistic Map ◽  
Deep Brain

OBJECTIVEThe objective of this study was to report the authors’ experience with deep brain stimulation (DBS) of the internal globus pallidus (GPi) as a treatment for pediatric dystonia, and to elucidate substrates underlying clinical outcome using state-of-the-art neuroimaging techniques.METHODSA retrospective analysis was conducted in 11 pediatric patients (6 girls and 5 boys, mean age 12 ± 4 years) with medically refractory dystonia who underwent GPi-DBS implantation between June 2009 and September 2017. Using pre- and postoperative MRI, volumes of tissue activated were modeled and weighted by clinical outcome to identify brain regions associated with clinical outcome. Functional and structural networks associated with clinical benefits were also determined using large-scale normative data sets.RESULTSA total of 21 implanted leads were analyzed in 11 patients. The average follow-up duration was 19 ± 20 months (median 5 months). Using a 7-point clinical rating scale, 10 patients showed response to treatment, as defined by scores < 3. The mean improvement in the Burke-Fahn-Marsden Dystonia Rating Scale motor score was 40% ± 23%. The probabilistic map of efficacy showed that the voxel cluster most associated with clinical improvement was located at the posterior aspect of the GPi, comparatively posterior and superior to the coordinates of the classic GPi target. Strong functional and structural connectivity was evident between the probabilistic map and areas such as the precentral and postcentral gyri, parietooccipital cortex, and brainstem.CONCLUSIONSThis study reported on a series of pediatric patients with dystonia in whom GPi-DBS resulted in variable clinical benefit and described a clinically favorable stimulation site for this cohort, as well as its structural and functional connectivity. This information could be valuable for improving surgical planning, simplifying programming, and further informing disease pathophysiology.

Altered structural connectivity associated with motor improvement in chronic supratentorial ischemic stroke

Neuroreport ◽  
2019 ◽  
Vol 30 (9) ◽  
pp. 688-693 ◽  
Author(s):  
Seung Hwa Lee ◽  
Sunghyon Kyeong ◽  
Hyunkoo Kang ◽  
Sohyon Kyeong ◽  
Dae Hyun Kim
Keyword(s):  
Ischemic Stroke ◽  
Structural Connectivity ◽  
Motor Improvement

An Accurate Prediction of Hydration Free Energies by Combination of Molecular Integral Equations Theory with Structural Descriptors

2010 ◽  
Vol 114 (37) ◽  
pp. 12068-12079 ◽  
Author(s):  
Ekaterina L. Ratkova ◽  
Gennady N. Chuev ◽  
Volodymyr P. Sergiievskyi ◽  
Maxim V. Fedorov
Keyword(s):  
Integral Equations ◽  
Accurate Prediction ◽  
Free Energies ◽  
Molecular Integral ◽  
Structural Descriptors
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