Metal ion clip: fine-tuning aromatic stacking interactions in the multistep formation of carbazole-bridged zinc(ii) complexes

2015 ◽  
Vol 51 (50) ◽  
pp. 10103-10106 ◽  
Author(s):  
Yuki Imai ◽  
Tsuyoshi Kawai ◽  
Junpei Yuasa
Keyword(s):  
Metal Ion ◽  
Fine Tuning ◽  
Stacking Interactions ◽  
Aromatic Stacking ◽  
Bridging Ligand

A carbazole-based triple bridging ligand (LH) consisting of two imidazole moieties with a diketone unit forms carbazole-bridged zinc(ii) complexes with structures of [(L−)4(Zn2+)n] (n = 2–6), where the strength of aromatic stacking interactions between the carbazole rings increases with an increase in the number of Zn2+ ions bridged.

A Chemical Perspective to the Anti-Amyloid Action of Compounds and a Nanoparticle Based Assay for Screening Amyloid Inhibitors

2020 ◽  
Author(s):  
Nidhi Gour ◽  
Bharti Koshti
Keyword(s):  
Memory Loss ◽  
Cost Effective ◽  
Structural Motif ◽  
Rapid Screening ◽  
Stacking Interactions ◽  
Aromatic Rings ◽  
Amyloid Fibers ◽  
Aromatic Stacking ◽  
Cost Effective Technique ◽  
The Brain

Aggregation of amyloid beeta 1-42 (Aβ<sub>42</sub>) peptide causes the formation of clustered deposits knows as amyloid plaques in the brain which leads to neuronal dysfunction and memory loss and associated with many neurological disorders including Alzheimer’s and Parkinson’s. Aβ<sub>42</sub> has core structural motif with phenylalanine at the 19 and 20 positions. The diphenylalanine (FF) residue plays a crucial role in the formation of amyloid fibers and serves as model peptide for studying Aβ<sub>42 </sub>aggregation. FF self-assembles to well-ordered tubular morphology via aromatic pi-pi stackings. Our studies, suggest that the aromatic rings present in the anti-amyloidogenic compounds may interact with the pi-pi stacking interactions present in the FF. Even the compounds which do not have aromatic rings, like cyclodextrin and cucurbituril show anti-amyloid property due to the binding of aromatic ring inside the guest cavity. Hence, our studies also suggest that compounds which may have a functional moiety capable of interacting with the aromatic stacking interactions might be tested for their anti-amyloidogenic properties. Further, in this manuscript, we have proposed two novel nanoparticle based assays for the rapid screening of amyloid inhibitors. In the first assay, interaction between biotin-tagged FF peptide and the streptavidin labelled gold nanoparticles (s-AuNPs) were used. In another assay, thiol-Au interactions were used to develop an assay for detection of amyloid inhibitors. It is envisaged that the proposed analytical method will provide a simple, facile and cost effective technique for the screening of amyloid inhibitors and may be of immense practical implications to find the therapeutic remedies for the diseases associated with the protein aggregation.

Fine tuning of phosphodiesterasse models activity using allosteric effect of metal ion coordination

2003 ◽  
Vol 96 (1) ◽  
pp. 193
Author(s):  
Larisa A. Mokhir ◽  
Markus Hoppe ◽  
Hans Pritzkow ◽  
Igor O. Fritsky ◽  
Roland Kraemer
Keyword(s):  
Metal Ion ◽  
Fine Tuning ◽  
Allosteric Effect

scholarly journals Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase

FEBS Journal ◽  
2015 ◽  
Vol 282 (16) ◽  
pp. 3091-3106 ◽  
Author(s):  
Patricia Ferreira ◽  
Aitor Hernández-Ortega ◽  
Fátima Lucas ◽  
Juan Carro ◽  
Beatriz Herguedas ◽  
...  
Keyword(s):  
Alcohol Oxidase ◽  
Stacking Interactions ◽  
Aromatic Stacking

scholarly journals catena-Poly[[[4-amino-3,5-bis(pyridin-2-yl)-4H-1,2,4-triazole-κ2N1,N5](dicyanamido-κN)copper(II)]-μ2-dicyanamido-κ2N:N′]: coordination polymer chains linked into a bilayer by hydrogen bonds and π–π stacking interactions

2014 ◽  
Vol 70 (4) ◽  
pp. 359-363 ◽  
Author(s):  
Zouaoui Setifi ◽  
Fatima Setifi ◽  
Mohamed Saadi ◽  
Djamil-Azzeddine Rouag ◽  
Christopher Glidewell
Keyword(s):  
Coordination Polymer ◽  
Hydrogen Bonds ◽  
Polymer Chains ◽  
Stacking Interactions ◽  
Terminal Ligand ◽  
One Dimensional ◽  
Bridging Ligand ◽  
Pyramidal Geometry ◽  
Π Stacking ◽  
Square Pyramidal Geometry

In the title compound, [Cu(C2N3)2(C12H10N6)]nor [Cu(dca)2(abpt)]n, where abpt is 4-amino-3,5-bis(pyridin-2-yl)-4H-1,2,4-triazole and dca is the dicyanamide anion, the CuIIcentre is five-coordinate with an approximately square-pyramidal geometry. One of the two dicyanamide ligands is a terminal ligand, but the other one acts as a μ1,5-bridging ligand between pairs of CuIIcentres, so generating a one-dimensional coordination polymer. A combination of N—H...N and C—H...N hydrogen bonds, augmented by π–π stacking interactions, links the coordination polymer chains into a bilayer structure. Comparisons are made with some related CuIIcomplexes containing dca ligands and heteroaromatic co-ligands.

A Supramolecular System for Quantifying Aromatic Stacking Interactions

2001 ◽  
Vol 7 (22) ◽  
pp. 4863-4877 ◽  
Author(s):  
Harry Adams ◽  
Christopher A. Hunter ◽  
Kevin R. Lawson ◽  
Julie Perkins ◽  
Sharon E. Spey ◽  
...  
Keyword(s):  
Supramolecular System ◽  
Stacking Interactions ◽  
Aromatic Stacking

Influence of metal ion on chelate-aryl stacking interactions

2018 ◽  
Vol 118 (16) ◽  
pp. e25629 ◽  
Author(s):  
Dušan P. Malenov ◽  
Michael B. Hall ◽  
Snežana D. Zarić
Keyword(s):  
Metal Ion ◽  
Stacking Interactions
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