From slow to fast – the user controls the rate of the release of molecules from masked forms using a photoswitch and different types of light

2015 ◽  
Vol 51 (32) ◽  
pp. 7039-7042 ◽  
Author(s):  
C. Chad Warford ◽  
Carl-Johan Carling ◽  
Neil R. Branda
Keyword(s):  
Visible Light ◽  
Small Molecule ◽  
Different Types

Light-gated release of a small molecule increases when exposed to UV or visible light.

Nitroacenaphthene as a New Photocatalyst for the Synthesis of Sulfonyl Amidines

Synthesis ◽  
2019 ◽  
Vol 51 (23) ◽  
pp. 4425-4433
Author(s):  
Yong Jian ◽  
Ming Chen ◽  
Chao Yang ◽  
Wujiong Xia
Keyword(s):  
Visible Light ◽  
Small Molecule ◽  
Reaction Pathways ◽  
Visible Light Photocatalyst ◽  
Mild Conditions ◽  
Sulfonyl Azides ◽  
Site Selective ◽  
First Time

A small molecule, namely nitroacenaphthene, is reported for the first time as a recyclable visible-light photocatalyst for the construction of the C=N bond from sulfonyl azides and amines. This scalable, site-selective protocol provides a convenient way to access various sulfonyl amidines under mild conditions. Two reaction pathways are proposed, according to different transformation patterns.

scholarly journals Competition NMR for Detection of Hit/Lead Inhibitors of Protein–Protein Interactions

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3017 ◽  
Author(s):  
Bogdan Musielak ◽  
Weronika Janczyk ◽  
Ismael Rodriguez ◽  
Jacek Plewka ◽  
Dominik Sala ◽  
...  
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Point Mutations ◽  
Protein Protein Interactions ◽  
Competition Assay ◽  
Fragment Screening ◽  
Different Types ◽  
Lead Inhibitors

Screening for small-molecule fragments that can lead to potent inhibitors of protein–protein interactions (PPIs) is often a laborious step as the fragments cannot dissociate the targeted PPI due to their low μM–mM affinities. Here, we describe an NMR competition assay called w-AIDA-NMR (weak-antagonist induced dissociation assay-NMR), which is sensitive to weak μM–mM ligand–protein interactions and which can be used in initial fragment screening campaigns. By introducing point mutations in the complex’s protein that is not targeted by the inhibitor, we lower the effective affinity of the complex, allowing for short fragments to dissociate the complex. We illustrate the method with the compounds that block the Mdm2/X-p53 and PD-1/PD-L1 oncogenic interactions. Targeting the PD-/PD-L1 PPI has profoundly advanced the treatment of different types of cancers.

scholarly journals Radical Carbonylative Synthesis of Heterocycles by Visible Light Photoredox Catalysis

Catalysts ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1054
Author(s):  
Xiao-Qiang Hu ◽  
Zi-Kui Liu ◽  
Wen-Jing Xiao
Keyword(s):  
Visible Light ◽  
Efficient Synthesis ◽  
Acyl Radical ◽  
Acyl Chlorides ◽  
Aryl Radicals ◽  
Keto Acids ◽  
Acyl Radicals ◽  
Different Types ◽  
The Impact ◽  
Visible Light Photocatalytic

Visible light photocatalytic radical carbonylation has been established as a robust tool for the efficient synthesis of carbonyl-containing compounds. Acyl radicals serve as the key intermediates in these useful transformations and can be generated from the addition of alkyl or aryl radicals to carbon monoxide (CO) or various acyl radical precursors such as aldehydes, carboxylic acids, anhydrides, acyl chlorides or α-keto acids. In this review, we aim to summarize the impact of visible light-induced acyl radical carbonylation reactions on the synthesis of oxygen and nitrogen heterocycles. The discussion is mainly categorized based on different types of acyl radical precursors.

scholarly journals Varying experimental conditions to study interactions in the solid state

2014 ◽  
Vol 70 (a1) ◽  
pp. C631-C631
Author(s):  
Elena Boldyreva
Keyword(s):  
Crystal Structure ◽  
Solid State ◽  
Crystal Structures ◽  
Intermolecular Interactions ◽  
Small Molecule ◽  
Variable Temperature ◽  
Variable Pressure ◽  
Continuous Lattice ◽  
Experimental Conditions ◽  
Different Types

Supramolecular interactions in the solid state attract much attention. Different experimental and computational approaches are used, to predict and to design crystal structures, to predict the properties based on molecular and crystal structures, to range different types of intermolecular interactions. Analysis of the crystal structures at fixed (e.g. ambient) temperature and pressure conditions is most common for experiments, whereas most DFT calculations are limited to 0 K, to minimize computational costs. At the same time, evolution of a crystal structure as a function of experimental conditions can contribute significantly to understanding the structure-forming role and relative energies of different types of intermolecular interactions in the same crystal structure and of similar interactions in a series of different but structurally or chemically related compounds. In the present invited contribution I attempt to illustrate this using several selected examples from my own practice and from the papers published by other research groups. I consider, in particular, the results of variable-temperature and variable-pressure studies of continuous lattice strain and phase transitions in small-molecule organic compounds, the results of variable-temperature and variable-pressure crystallization, the results of comparing the dissolution profiles of mono- and multi-component small-molecule organic crystals. I shall also discuss how variable-temperature and variable-pressure experimental diffraction data can assist in optimizing the calculations aimed at comparing the relative stability of polymorphs and predicting polymorph transitions. The study was supported by Russian Ministry of Science and Education and Russian Academy of Sciences.

scholarly journals Biscoumarin-containing acenes as stable organic semiconductors for photocatalytic oxygen reduction to hydrogen peroxide

2017 ◽  
Vol 5 (39) ◽  
pp. 20780-20788 ◽  
Author(s):  
Marek K. Węcławski ◽  
Marie Jakešová ◽  
Martyna Charyton ◽  
Nicola Demitri ◽  
Beata Koszarna ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Visible Light ◽  
Oxygen Reduction ◽  
Organic Semiconductors ◽  
Small Molecule ◽  
Light Illumination ◽  
Visible Light Illumination

Organic small-molecule semiconductors can be photocatalysts in their own right, oxidizing water while reducing oxygen to hydrogen peroxide under visible light illumination.

Metal nanoparticles embedded in AIEE active supramolecular assemblies: robust, green and reusable nanocatalysts

2019 ◽  
Vol 48 (15) ◽  
pp. 4769-4773 ◽  
Author(s):  
Harnimarta Deol ◽  
Gurpreet Singh ◽  
Manoj Kumar ◽  
Vandana Bhalla
Keyword(s):  
Visible Light ◽  
Metal Nanoparticles ◽  
Visible Light Irradiation ◽  
Supramolecular Assemblies ◽  
Light Irradiation ◽  
Organic Transformations ◽  
Different Types

Multi-functional AIEE-active supramolecular assemblies act as nanoreactors for the preparation of different types of metal NPs. The in situ generated metal NPs stabilized by supramolecular assemblies act as nanocatalysts for various organic transformations under thermal/visible light irradiation.

Photocatalytic oxidation of small molecule hydrocarbons over Pt/TiO2 nanocatalysts

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 2760-2767 ◽  
Author(s):  
Yunpeng Li ◽  
Yuanzhu Cai ◽  
Xuxing Chen ◽  
Xiaoyang Pan ◽  
Mingxue Yang ◽  
...  
Keyword(s):  
Visible Light ◽  
Small Molecule ◽  
Photocatalytic Oxidation ◽  
Light Activity

Pt loading on P25 resulted in unexpected visible light activity for the oxidation of small molecule hydrocarbons.

Structural Design Principle of Small-Molecule Organic Semiconductors for Metal-Free, Visible-Light-Promoted Photocatalysis

2016 ◽  
Vol 55 (33) ◽  
pp. 9783-9787 ◽  
Author(s):  
Lei Wang ◽  
Wei Huang ◽  
Run Li ◽  
Dominik Gehrig ◽  
Paul W. M. Blom ◽  
...  
Keyword(s):  
Visible Light ◽  
Organic Semiconductors ◽  
Small Molecule ◽  
Structural Design ◽  
Design Principle ◽  
Metal Free
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