Delivering anti-cancer drugs with endosomal pH-sensitive anti-cancer liposomes

2016 ◽  
Vol 4 (4) ◽  
pp. 627-638 ◽  
Author(s):  
Gopikrishna Moku ◽  
Suresh Kumar Gulla ◽  
Narendra Varma Nimmu ◽  
Sara Khalid ◽  
Arabinda Chaudhuri
Keyword(s):  
Drug Carriers ◽  
Ph Sensitive ◽  
Acidic Ph ◽  
Cancer Drugs ◽  
Tumor Tissues ◽  
Anti Cancer ◽  
Endosomal Ph

Numerous prior studies have been reported on the use of pH-sensitive drug carriers such as micelles, liposomes, peptides, polymers, nanoparticles,etc. that are sensitive to the acidic (pH = ∼6.5) microenvironments of tumor tissues.

scholarly journals pH-Sensitive Ratiometric Fluorescent Probe for Evaluation of Tumor Treatments

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1632
Author(s):  
Peisen Zhang ◽  
Junli Meng ◽  
Yingying Li ◽  
Zihua Wang ◽  
Yi Hou
Keyword(s):  
Ph Sensitive ◽  
Fluorescent Imaging ◽  
Tat Peptide ◽  
Cancer Drugs ◽  
Ph Response ◽  
In Vivo Experiments ◽  
Anti Cancer ◽  
Amidation Reaction

Determining therapeutic efficacy is critical for tumor precision theranostics. In order to monitor the efficacy of anti-cancer drugs (e.g., Paclitaxel), a pH-sensitive ratiometric fluorescent imaging probe was constructed. The pH-sensitive ratiometric fluorescent dye ANNA was covalently coupled to the N-terminal of the cell-penetrating TAT peptide through an amidation reaction (TAT-ANNA). The in vitro cellular experiments determined that the TAT-ANNA probe could penetrate the cell membrane and image the intracellular pH in real time. The in vivo experiments were then carried out, and the ratiometric pH response to the state of the tumor was recorded immediately after medication. The TAT-ANNA probe was successfully used to monitor the pharmacodynamics of anti-cancer drugs in vivo.

Dual-vectors of anti-cancer drugs and genes based on pH-sensitive micelles self-assembled from hybrid polypeptide copolymers

2011 ◽  
Vol 21 (9) ◽  
pp. 3100 ◽  
Author(s):  
Yong-Yong Li ◽  
Shou-Hu Hua ◽  
Wang Xiao ◽  
Hui-Yuan Wang ◽  
Xiao-Hua Luo ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Self Assembled

Multilayer fluorescent magnetic nanoparticles with dual thermoresponsive and pH-sensitive polymeric nanolayers as anti-cancer drug carriers

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 29653-29662 ◽  
Author(s):  
Maziar Torkpur-Biglarianzadeh ◽  
Mehdi Salami-Kalajahi
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Carriers ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Anti Cancer

Fluorescent magnetic nanoparticles with dual thermoresponsive and pH-sensitive polymeric nanolayers as anti-cancer drug carriers.

scholarly journals Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement

2020 ◽  
Vol 10 (4) ◽  
pp. 524-541
Author(s):  
Shashank Chaturvedi ◽  
Anurag Verma ◽  
Vikas Anand Saharan
Keyword(s):  
Drug Exposure ◽  
Biological Membrane ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Cancer Drugs ◽  
Proliferating Cells ◽  
Bioavailability Enhancement ◽  
Glycoprotein P ◽  
Anti Cancer ◽  
Lymphatic Route

In the treatment of cancer, chemotherapy plays an important role though the efficacy of anticancer drug administered orally is limited, due to their poor solubility in physiological medium, inability to cross biological membrane, high Para-glycoprotein (P-gp) mediated drug efflux, and pre-systemic metabolism. These all factors cumulatively reduce drug exposure at the target site leading to multidrug resistance (MDR). Lipid based carriers systems has been explored to overcome solubility and permeability related issues of anti-cancer drugs. The lipid based formulations have also been reported to circumvent the effect of P-gp and CYP3A4. Further long chain triglycerides (LCT) has shown their ability to access Lymphatic route over Medium Chain Triglycerides, as the former has been extensively used for targeting anti-cancer drugs at proliferating cells through lymphatic route. Therefore this review tries to reflect the usefulness of lipid based drug carriers systems (viz. liposome, solid lipid nanoparticle, nano-lipid carriers, self-emulsifying, lipidic pro-drugs) in targeting lymphatic system and overcoming issues related to solubility and permeability of anti-cancer drugs. Moreover, we have also tried to reflect how critically lipid based carriers are important in maximizing therapeutic safety and efficacy of anti-cancer drugs.

scholarly journals pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1899 ◽  
Author(s):  
Evgeny Apartsin ◽  
Nadezhda Knauer ◽  
Valeria Arkhipova ◽  
Ekaterina Pashkina ◽  
Alina Aktanova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Smart Vehicles ◽  
New Class ◽  
Self Assembling ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

A Case of Malignant Melanoma Treated with a Combination of Anti-Cancer Drugs and Biological Response Modifiers.

1993 ◽  
Vol 55 (1) ◽  
pp. 43-46
Author(s):  
Jun YOSHIDA ◽  
Juichiro NAKAYAMA ◽  
Nobuyuki SHIMIZU ◽  
Shonosuke NAGAE ◽  
Yoshiaki HORI
Keyword(s):  
Malignant Melanoma ◽  
Biological Response ◽  
Biological Response Modifiers ◽  
Cancer Drugs ◽  
Anti Cancer

Current Scenario in Structure and Ligand-Based Drug Design on Anti-colon Cancer Drugs

2019 ◽  
Vol 24 (32) ◽  
pp. 3829-3841 ◽  
Author(s):  
Lakshmanan Loganathan ◽  
Karthikeyan Muthusamy
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Anticancer Agent ◽  
Computational Power ◽  
Cancer Drugs ◽  
Recent Advances ◽  
Anti Cancer ◽  
Drug Designing ◽  
Current Scenario ◽  
Molecular Modeling Studies

Worldwide, colorectal cancer takes up the third position in commonly detected cancer and fourth in cancer mortality. Recent progress in molecular modeling studies has led to significant success in drug discovery using structure and ligand-based methods. This study highlights aspects of the anticancer drug design. The structure and ligand-based drug design are discussed to investigate the molecular and quantum mechanics in anti-cancer drugs. Recent advances in anticancer agent identification driven by structural and molecular insights are presented. As a result, the recent advances in the field and the current scenario in drug designing of cancer drugs are discussed. This review provides information on how cancer drugs were formulated and identified using computational power by the drug discovery society.

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