scholarly journals Three-dimensional multilayered fibrous constructs for wound healing applications

2016 ◽  
Vol 4 (2) ◽  
pp. 319-330 ◽  
Author(s):  
Tiago C. Reis ◽  
Steven Castleberry ◽  
Ana M. B. Rego ◽  
Ana Aguiar-Ricardo ◽  
Paula T. Hammond
Keyword(s):  
Wound Healing ◽  
Physicochemical Properties ◽  
Three Dimensional ◽  
Wound Dressings ◽  
Self Organization ◽  
Electrospun Fibers

Electrical driven self-organization of electrospun fibers is used to create topographically bioinspired three-dimensional multilayered constructs, with tunable morphological and physicochemical properties for ideal wound dressings.

scholarly journals Electrospun nanofibers for the fabrication of engineered vascular grafts

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Sonia Fathi Karkan ◽  
Soodabeh Davaran ◽  
Reza Rahbarghazi ◽  
Roya Salehi ◽  
Abolfazl Akbarzadeh
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Physicochemical Properties ◽  
Review Paper ◽  
Vascular Grafts ◽  
Three Dimensional ◽  
Electrospun Nanofibers ◽  
Electrospun Fibers

Abstract Attention has recently increased in the application of electrospun fibers because of their putative capability to create nanoscale platforms toward tissue engineering. To some extent, electrospun fibers are applicable to the extracellular matrix by providing a three-dimensional microenvironment in which cells could easily acquire definite functional shape and maintain the cell-to-cell connection. It is noteworthy to declare that placement in different electrospun substrates with appropriate physicochemical properties enables cells to promote their bioactivities, dynamics growth and differentiation, leading to suitable restorative effects. This review paper aims to highlight the application of biomaterials in engineered vascular grafts by using electrospun nanofibers to promote angiogenesis and neovascularization

scholarly journals Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

2020 ◽  
Vol 13 (05) ◽  
pp. 2030012 ◽  
Author(s):  
Zhimei Wei ◽  
Liqun Wang ◽  
Shouyu Zhang ◽  
Tonghai Chen ◽  
Jie Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biomedical Applications ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Electrospun Fibers ◽  
Chronic Infections ◽  
Antibacterial Material

Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used in many biomedical applications including drug delivery, regenerative medicine, wound healing and so on. Thus, this review provides an overview of all recently published studies on the development of electrospun antibacterial nanofibers in wound dressings and tissue medicinal fields. This reviewer begins with a brief introduction of electrospinning process and then discusses electrospun fibers by incorporating various types of antimicrobial agents used as in wound dressings and tissue. Finally, we finish with conclusions and further perspectives on electrospun antibacterial nanofibers as 2D biomedicine materials.

Insight into the bioactive hydrogels for wound healing and drug delivery systems

2021 ◽  
Vol 28 ◽  
Author(s):  
Jing Li ◽  
Qinhua Chen ◽  
Jin Wang ◽  
Xiaoyan Pan ◽  
Jie Zhang
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Delivery Systems ◽  
Three Dimensional ◽  
Polymer System ◽  
Delivery Systems ◽  
Water Soluble ◽  
Wound Dressings ◽  
Water Soluble Polymer ◽  
Dimensional Network

: Hydrogel is a hydrophilic but water-soluble polymer system with a three-dimensional network structure. Hydrogel can absorb large amounts of water and maintain its shape and remain soft. The high-moisturizing properties, good biocompatibility and controlled biodegradability of hydrogels have allowed them to be widely used in wound dressing, tissue engineering, controlled drug delivery systems and other fields. This article reviews the most widely used antibacterial gel dressings for wound healing in recent years and focuses on the application of an environmentally responsive intelligent hydrogel delivery system. Finally, the development prospects and challenges of hydrogel wound dressings are forecasted.

scholarly journals Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

2021 ◽  
Vol 22 (7) ◽  
pp. 3391
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska ◽  
Ewa Olewnik-Kruszkowska ◽  
Katarzyna Reczyńska ◽  
Elżbieta Pamuła
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Silk Fibroin ◽  
Three Dimensional ◽  
Microscopy Imaging ◽  
Maximum Deformation ◽  
One Step ◽  
Chitosan Blends ◽  
Fourier Transfer Infrared Spectroscopy

The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm3; cross-linked with DAC: 14.6 ± 0.7 g/cm3) and lower mechanical properties (maximum deformation for DAC cross-linked scaffolds was about 69%; for DAS cross-linked scaffolds it was in the range of 12.67 ± 1.51% and 19.83 ± 1.30%) in comparison to materials cross-linked with DAC. Additionally, scaffolds cross-linked with DAS exhibited higher biocompatibility than those cross-linked with DAC. However, the obtained results showed that both types of scaffolds can provide the support required in regenerative medicine and tissue engineering. The scaffolds presented in the present work can be potentially used in bone tissue engineering to facilitate healing of small bone defects.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Elastic Janus film for Wound Dressings: Unidirectional Biofluid Transport and Effectively Promoting Wound Healing

2021 ◽  
pp. 2105265
Author(s):  
Bing Xu ◽  
Ang Li ◽  
Rui Wang ◽  
Juan Zhang ◽  
Yinlong Ding ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings

scholarly journals Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 713
Author(s):  
Nina Melnikova ◽  
Alexander Knyazev ◽  
Viktor Nikolskiy ◽  
Peter Peretyagin ◽  
Kseniia Belyaeva ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zinc Oxide ◽  
Bacterial Cellulose ◽  
Zinc Oxide Nanoparticles ◽  
Wound Dressings ◽  
Oxide Nanoparticles ◽  
Burn Wound ◽  
Zno Nps ◽  
Wound Model ◽  
And Oxidative Stress

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5–25%) corresponded to 5–6 nm and 10–18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings “BC-ZnO NPs-BDP” was investigated in rats using a burn wound model. Morpho-histological studies have shown that more intensive healing was observed during treatment with hydrophilic nanocomposites than the oleophilic standard (ZnO NPs-BDP oleogel; p < 0.001). Treatment by both hydrophilic and lipophilic agents led to increases in antioxidant enzyme activity (superoxide dismutase (SOD), catalase) in erythrocytes and decreases in the malondialdehyde (MDA) concentration by 7, 10 and 21 days (p < 0.001). The microcirculation index was restored on the 3rd day after burn under treatment with BC-ZnO NPs-BDP wound dressings. The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.

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