Folic acid conjugated magnetic iron oxide nanoparticles for nondestructive separation and detection of ovarian cancer cells from whole blood

2016 ◽  
Vol 4 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Wenting Liu ◽  
Liju Nie ◽  
Fulai Li ◽  
Zoraida P. Aguilar ◽  
Hong Xu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Folic Acid ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Whole Blood ◽  
Ovarian Cancer Cells ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles

An effective method for separation and detection of ovarian cancer cells from whole blood using folic acid conjugated magnetic nanoparticles.

scholarly journals A Comprehensive Review of the Diagnostic and Treatment Methods for Ovarian Cancer

2018 ◽  
Vol 3 (2) ◽  
pp. 13
Author(s):  
Michelle Davis
Keyword(s):  
Ovarian Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Standard Of Care ◽  
Ovarian Cancer Cells ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Ovarian Cancers

Ovarian cancer is amongst the most life-threatening malignancy of the female reproductive system, whereas 90% of those ovarian cancers are epithelial with an overall poor five-year survival rate of 44% across all stages and all races [1]–[2], [31]. This paper aims to review the current treatment and diagnostic strategies for ovarian cancer [3]. Using grounded substantial research, multiple figures were developed to show the relations of ovarian cancer diagnostics and ovarian cancer therapeutics.  It is a great start to look into what may be causing most patients to become resistant to the current standard of care, platinum-based chemotherapeutics, for ovarian cancer [4]. A comprehensive literature review will be used to understand the genetic basis of the disease and possible cancer growth patterns, so we could possibly introduce better diagnostics and therapeutics [5]. The findings show that there are a variety of treatments options other than the standard of care, platinum-based therapy [6]. Nanoparticle encapsulation therapy is one way that has been approved by the FDA to therapeutically treat ovarian cancer without the platinum resistant side effects [7]. Also, the discovery of different diagnostics for ovarian cancer can help with better individualized treatments for patients with different forms of ovarian cancer [8]. Currently, the only serous diagnostic test for the detection of ovarian cancer is high levels of Cancer Antigen 125 (CA-125), which is only shown in 50% of early staged ovarian cancers [16]. The main treatment option for ovarian cancer is platinum-based drugs, in which most cases of patients with ovarian cancer will become resistant. Detecting and treating ovarian cancer while the cells are small, contained, and still in the early stages in vivo still remains to be a challenge [9]. Here, we will demonstrate the bioelectrical interactions of the ovarian cancer cells fused with the magnetic iron oxide nanoparticles with the use of an MRI. The findings demonstrate that the diagnostic method for the early detection of epithelial ovarian cancer requires the use of magnetic iron oxide nanoparticles with specific ligand external profiles as a contrast reagent to make the small-sized ovarian cancer cells appear more visible under MRI. 

scholarly journals Efficient delivery of chlorin e6 into ovarian cancer cells with octalysine conjugated superparamagnetic iron oxide nanoparticles for effective photodynamic therapy

2016 ◽  
Vol 4 (47) ◽  
pp. 7741-7748 ◽  
Author(s):  
Li Zhao ◽  
Hongkuan Yang ◽  
Tsukuru Amano ◽  
Hongmei Qin ◽  
Luyi Zheng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Photodynamic Therapy ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Chlorin E6 ◽  
Ovarian Cancer Cells ◽  
Oxide Nanoparticles ◽  
Efficient Delivery

Chlorin e6, loaded on the surface of SPION-PG-Lys8 through electrostatic attraction, was delivered preferentially into mitochondria of SKOV3 ovarian cancer cells, improving efficacy of photodynamic therapy significantly.

Sensitization of cisplatin-resistant ovarian cancer cells by magnetite iron oxide nanoparticles: an in vitro study

Nanomedicine ◽  
2019 ◽  
Vol 14 (24) ◽  
pp. 3177-3191
Author(s):  
Kurtulus Gokduman
Keyword(s):  
Ovarian Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
In Vitro Study ◽  
Ovarian Cancer Cells ◽  
Oxide Nanoparticles ◽  
Particle Size Analyzer ◽  
20 Nm

Aim: To investigate potential of magnetite iron oxide nanoparticles (MION) to sensitize cisplatin-resistant ovarian cancer cells to cisplatin, which to the best of found knowledge has not been reported previously. Materials & methods: MION with a diameter of approximately 20 nm were synthesized, and characterized using Fourier transform infrared spectroscopy, powder x-ray diffraction and particle size analyzer. Results: The synthesized MION have increased reactive oxygen species levels and decreased glutathione levels in cisplatin-resistant ovarian cancer cells (OVCAR-3 and SKOV-3). Using MTT, capsase-3 activity and live/dead assays, capability of the synthesized MION to sensitize cisplatin-resistant ovarian cancer cells has been illustrated. Conclusion: Thus, for further investigations, the synthesized MION can be considered as a potent agent enabling much more effective cisplatin-based therapies for ovarian cancer.

Surface active magnetic iron oxide nanoparticles for extracting metal nanoparticles across an aqueous–organic interface

2019 ◽  
Vol 7 (34) ◽  
pp. 10623-10634 ◽  
Author(s):  
Meenakshi Verma ◽  
Kultar Singh ◽  
Mandeep Singh Bakshi
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Metal Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Gemini Surfactants ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Surface Active

Highly surface active magnetic nanoparticles (Fe3O4 NPs) were synthesized by using tetraalkylammonium and imidazolium Gemini surfactants.

scholarly journals Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

2018 ◽  
Vol 9 ◽  
pp. 1613-1622 ◽  
Author(s):  
Sašo Gyergyek ◽  
David Pahovnik ◽  
Ema Žagar ◽  
Alenka Mertelj ◽  
Rok Kostanjšek ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Methyl Methacrylate ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Uniform Loading ◽  
Magnetic Iron Oxide ◽  
Induced Hyperthermia ◽  
Pmma Matrix

Nanocomposites with a high, uniform loading of magnetic nanoparticles are very desirable for applications such as electromagnetic shielding and cancer treatment based on magnetically induced hyperthermia. In this study, a simple and scalable route for preparing nanocomposites with a high, uniform loading of magnetic nanoparticles is presented. The magnetic iron-oxide nanoparticles were functionalized with a methacrylate-based monomer that copolymerized in a toluene solution with the methyl methacrylate (MMA) monomer. The resulting suspension of magnetic nanoparticles decorated with poly(methyl methacrylate) (PMMA) chains in toluene were colloidal, even in the presence of a magnetic field gradient. Nanocomposites were precipitated from these suspensions. The transmission electron microscopy investigation of the prepared nanocomposites revealed that the magnetic nanoparticles were homogeneously dispersed in the PMMA matrix, even in amounts up to 53 wt %. The uniform dispersion of the nanoparticles in the PMMA matrix was attributed to the good solvation of the grafted PMMA chains from the magnetic nanoparticles by the PMMA chains of the matrix. The nanocomposites were superparamagnetic and exhibited large values for the saturation magnetization of up to 36 emu/g. Moreover, the nanocomposite with the largest amount of incorporated nanoparticles exhibited relatively large values for the specific power loss when subjected to alternating magnetic fields, giving this material great potential for the magnetically induced hyperthermia-based treatment of cancer.

Deep Eutectic Solvent Electrolysis for Preparing Water-Soluble Magnetic Iron Oxide Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Haiyang Jia ◽  
Jiawei Sun ◽  
Meng Dong ◽  
Hui Dong ◽  
Hongtao Zhang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Deep Eutectic Solvent ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

Magnetic iron oxide nanoparticles have been proven versatile applications in biomedicine. Although numerous strategies have been developed to synthsize hydrophilic magnetic nanoparticles, it is still a challenge in quantity and...

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