scholarly journals Smart branched polymer drug conjugates as nano-sized drug delivery systems

2015 ◽  
Vol 3 (10) ◽  
pp. 1321-1334 ◽  
Author(s):  
A. Duro-Castano ◽  
J. Movellan ◽  
M. J. Vicent
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Branched Polymers ◽  
Branched Polymer ◽  
Drug Conjugates ◽  
Polymer Drug Conjugates

Branched polymers own special properties derived from their intrinsic characteristics. These properties make them ideal candidates to be used as carriers for an improved generation of polymer-drug conjugates.

Polymer–Drug Conjugates as Drug Delivery Systems

2019 ◽  
pp. 61-75
Author(s):  
Sauraj Singh ◽  
Ruchir Priyadarshi ◽  
Bijender Kumar ◽  
Saleheen Bano ◽  
Farha Deeba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Conjugates ◽  
Polymer Drug Conjugates

Prospects of Delivering Natural Compounds by Polymer-Drug Conjugates in Cancer Therapeutics

2021 ◽  
Vol 21 ◽  
Author(s):  
Nompumelelo P. Mthimkhulu ◽  
Karabo S. Mosiane ◽  
Ekene E. Nweke ◽  
Mohammed Balogun ◽  
Pascaline Fru
Keyword(s):  
Drug Delivery ◽  
Plant Extracts ◽  
Drug Delivery Systems ◽  
Cancer Therapeutics ◽  
Natural Compounds ◽  
Delivery Systems ◽  
Drug Conjugates ◽  
Medicinal Plant Extracts ◽  
Novel Drug ◽  
Polymer Drug Conjugates

: Synthetic chemotherapeutics have played a crucial role in minimizing mostly palliative symptoms associated with cancer; however, they have also created other problems such as system toxicity due to a lack of specificity. This has led to the development of polymer-drug conjugates amongst other novel drug delivery systems. Most of the formulations designed using delivery systems consist of synthetic drugs and face issues such as drug resistance, which has already rendered drugs such as antibiotics ineffective. This is further exacerbated by toxicity due to long term use. Given these problems and the fact that conjugation of synthetic compounds to polymers has been relatively slow with no formulation on the market after a decade of extensive studies, the focus has shifted to using this platform with medicinal plant extracts to improve solubility, specificity and increase drug release of medicinal and herbal bioactives. In recent years, various plant extracts such as flavonoids, tannins and terpenoids have been studied extensively using this approach. The success of formulations developed using novel drug-delivery systems is highly dependent on the tumour microenvironment especially on the enhanced permeability and retention effect. As a result, the compromised lymphatic network and ‘leaky’ vasculature exhibited by tumour cells act as a guiding principle in the delivering of these formulations. This review focuses on the state of the polymer-drug conjugates and their exploration with natural compounds, the progress and difficulties thus far, and future directions concerning cancer treatment.

Cancer Nanotechnology-An Excursion on Drug Delivery Systems

2019 ◽  
Vol 18 (15) ◽  
pp. 2078-2092 ◽  
Author(s):  
Mala Sharma ◽  
Chitranshu Pandey ◽  
Neha Sharma ◽  
Mohammad A. Kamal ◽  
Usman Sayeed ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Cancer Chemoprevention ◽  
Delivery Systems ◽  
Nanostructured Lipid Carrier ◽  
Nanodrug Delivery ◽  
Drug Conjugates ◽  
Drug Nanoparticles ◽  
Cancer Nanotechnology

Background: Nanotechnology pictures a breakthrough in the domain of cancer therapy owing to its novel properties and functions. This technology is quite amendable as it allows the scientists to engineer drug nanoparticles of dimensions 10nm – 500nm permitting them to pass via leaky vasculature of tumorigenic microenvironment with higher specificity, reduced cytotoxicity and effective release without any after effects. The central part of the review zooms onto the role of nanoparticles and their targeted delivery for the cure of cancer. Methods: The novel and various versatile nanoparticle platforms viz. polymeric (drug-conjugates, micelles, dendrimers), Lipid-based (liposomes, solid nanoparticle, nanostructured lipid carrier, lipid-polymer hybrid), and stimuli-sensitive (thermoresponsive, ultrasound, pH-responsive, hydrogel) etc. have been designed for a persistent, précised nanodrug delivery and the co-delivery of collegial drug conjugates leading to the formation of safer release of myriad of drugs for cancer chemoprevention. Results: The review concerns about tracing and detailing the drug delivery systems of cancer nanotechnology. Conclusion: Nanotechnology is bestowed with the design, depiction, fabrication, and application of nanostructures, and devices with their controlled delivery together with the imaging of the selected target site and drug release at the specific site of action.

scholarly journals Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery

2019 ◽  
Vol 5 (8) ◽  
pp. eaax0780 ◽  
Author(s):  
Tejabhiram Yadavalli ◽  
Joshua Ames ◽  
Alex Agelidis ◽  
Rahul Suryawanshi ◽  
Dinesh Jaishankar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Antiviral Drug ◽  
Cost Effective ◽  
Delivery Systems ◽  
Carbon Particles ◽  
Drug Conjugates ◽  
Carbon Structures ◽  
Simplex Virus

Current drug-delivery systems are designed primarily for parenteral applications and are either lipid or polymer drug conjugates. In our quest to inhibit herpes simplex virus infection via the compounds found in commonly used cosmetic products, we found that activated carbon particles inhibit infection and, in addition, substantially improve topical delivery and, hence, the efficacy of a common antiviral drug, acyclovir (ACV). Our in vitro studies demonstrate that highly porous carbon structures trapped virions, blocked infection and substantially improved efficacy when ACV was loaded onto them. Also, using murine models of corneal and genital herpes infections, we show that the topical use of drug-encapsulated carbon (DECON) reduced dosing frequency, shortened treatment duration, and exhibited higher therapeutic efficacy than currently approved topical or systemic antivirals alone. DECON is a nontoxic, cost-effective and nonimmunogenic alternative to current topical drug-delivery systems that is uniquely triggered for drug release by virus trapping.

Targeting ovarian solid tumors by Elastin-like polypeptide drug conjugates: Current trends and future prospectives

2021 ◽  
Vol 22 ◽  
Author(s):  
Deepthi Ramamurthi ◽  
Moola Joghee Nanjan Chandrasekar ◽  
Shanthi Bhupathi Santhosh ◽  
Sunil Kumar Patnaik
Keyword(s):  
Drug Delivery ◽  
Solid Tumors ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Thermoresponsive Polymers ◽  
Anticancer Chemotherapy ◽  
Anticancer Drug Delivery ◽  
Stimuli Responsive Polymers ◽  
Drug Conjugates

Background: Ovarian cancer is one of the leading causes of death worldwide. Polymers have low cytotoxicity and high functional ability and hence used for drug delivery systems, tissue engineering, and polymer therapeutics. In drug delivery systems, polymer-drug conjugates have shown considerable promise, especially in anticancer chemotherapy. Objective: Anticancer drug delivery systems (DDS) deliver drugs to the tumor site, leading to reduced exposure to healthy cells and reduced side effects. Efforts have been made to develop effective DDS using stimuli-responsive polymers like thermo sensitive and pH-sensitive polymers. Conclusion: Elastin-like polypeptides (ELP), one of the thermoresponsive polymers, have been identified as drug carriers in anticancer therapy. ELP-drug conjugates have the potential and can be used effectively in combination with hyperthermia for targeting drugs to solid tumors. This review reports on the use of ELPs in cancer therapy, its biomedical applications, and recent developments to target medicines to solid ovarian tumors.

scholarly journals Polymer based Drug Delivery Systems- benchtop to Bedside Transition

2021 ◽  
Vol 2 (2) ◽  
pp. 1-3
Author(s):  
Priyanka Ray ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Materials ◽  
Therapeutic Index ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Drug Molecules ◽  
Drug Conjugates ◽  
Life Threatening ◽  
The Stability

Research in the field of polymers and polymeric materials has garnered immense attention in the past few decades due to the versatile functional and structural capabilities of polymers which often can be manipulated for applications in the field of therapy and diagnosis for a host of diseases and disorders. Polymer therapeutics comprises polymer-drug and polymer-protein conjugates as well as supramolecular systems used as drug delivery systems. Although the pharmacological industry invests immensely in the design and discovery of novel drug molecules, small molecular drugs are often inefficient in targeting many diseases like deep seated low vasculature tumours, metastasized cancers and various autoimmune diseases. Coupled with a rapid clearance rate, low solubility, drug resistance and high off target toxicity these small molecular drugs often present modest benefits for a host of common diseases. In order to improve the therapeutic index of pre-existing drugs and shortening the translation from preclinical validation to clinical approval, a vast area of drug delivery research focuses on the improvement of drug carriers by various alterations. The major challenges currently faced by drug delivery systems include a low payload, transition through the desmoplastic barrier for solid tumours and high hepatic and renal clearance. In order to address these issues numerous polymer–protein and polymer-drug conjugates have been engineered and have reported to enhance the stability and pharmacokinetic properties of the active drugs. Highly toxic anticancer drugs like doxorubicin, cis-platin and gemcitabine have successfully been coupled with high molecular weight polymers to formulate targeted drug delivery agents, some of which have undergone successful clinical trials. Apart from PEGylated polymers, dendritic polymers and polyplexes with DNA or RNA moieties have also been considered as candidates for improving the therapeutic index of various drugs. Ongoing efforts in the development of polymer-based therapeutics are promising and open new horizons for personalized medicine for effective cure of various life-threatening diseases.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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