A review on the latest developments in nanostructure-based electrochemical sensors for glutathione

2016 ◽  
Vol 8 (8) ◽  
pp. 1745-1754 ◽  
Author(s):  
Shabi Abbas Zaidi ◽  
Jae Ho Shin
Keyword(s):  
Molecular Mass ◽  
Normal Level ◽  
Electrochemical Sensors ◽  
Biological Fluids ◽  
Thiol Compound

Glutathione, a low molecular mass thiol compound, is considered a vital biomarker for various disease and cancers owing to the variation in the level of GSH from its normal level in the micromolar to millimolar range in biological fluids and cells.

Nuclease Hydrolysis Does Not Drive the Rapid Signaling Decay of DNA Aptamer-Based Electrochemical Sensors in Biological Fluids

Langmuir ◽  
2021 ◽  
Vol 37 (17) ◽  
pp. 5213-5221
Author(s):  
Alexander Shaver ◽  
Nandini Kundu ◽  
Brian E. Young ◽  
Philip A. Vieira ◽  
Jonathan T. Sczepanski ◽  
...  
Keyword(s):  
Electrochemical Sensors ◽  
Biological Fluids ◽  
Dna Aptamer ◽  
Rapid Signaling

The molecular mass and concentrations of protein 1 or Clara cell protein in biological fluids: A reappraisal

1993 ◽  
Vol 223 (1-2) ◽  
pp. 189-191 ◽  
Author(s):  
A. Bernard ◽  
X. Dumont ◽  
H. Roels ◽  
R. Lauwerys ◽  
I. Dierynck ◽  
...  
Keyword(s):  
Molecular Mass ◽  
Biological Fluids ◽  
Clara Cell ◽  
Cell Protein ◽  
Clara Cell Protein

scholarly journals Development of a Novel Biosensor Using Cationic Antimicrobial Peptide and Nickel Phthalocyanine Ultrathin Films for Electrochemical Detection of Dopamine

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Maysa F. Zampa ◽  
Inês Maria de S. Araújo ◽  
José Ribeiro dos Santos Júnior ◽  
Valtencir Zucolotto ◽  
José Roberto de S. A. Leite ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Electrochemical Sensors ◽  
Biological Fluids ◽  
Fundamental Aspect ◽  
Layer By Layer ◽  
Cationic Antimicrobial Peptide ◽  
Nickel Phthalocyanine ◽  
Layer Technique ◽  
Potential Applications ◽  
Pharmaceutical Industries

The antimicrobial peptide dermaseptin 01 (DS 01), from the skin secretion ofPhyllomedusa hypochondrialisfrogs, was immobilized in nanostructured layered films in conjunction with nickel tetrasulfonated phthalocyanines (NiTsPc), widely used in electronic devices, using layer-by-layer technique. The films were used as a biosensor to detect the presence of dopamine (DA), a neurotransmitter associated with diseases such as Alzheimer's and Parkinson's, with detection limits in the order of 10−6 mol L−1. The use of DS 01 in LbL film generated selectivity in the detection of DA despite the presence of ascorbic acid found in biological fluids. This work is the first to report that the antimicrobial peptide and NiTsPc LbL film exhibits electroanalytical activity to DA oxidation. The selectivity in the detection of DA is a fundamental aspect for the development of electrochemical sensors with potential applications in the biomedical and pharmaceutical industries.

scholarly journals Oxidative damage to hyaluronate and glucose in synovial fluid during exercise of the inflamed rheumatoid joint. Detection of abnormal low-molecular-mass metabolites by proton-n.m.r. spectroscopy

1991 ◽  
Vol 273 (2) ◽  
pp. 459-467 ◽  
Author(s):  
M Grootveld ◽  
E B Henderson ◽  
A Farrell ◽  
D R Blake ◽  
H G Parkes ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Molecular Mass ◽  
Biological Fluids ◽  
Reactive Oxygen ◽  
Oxygen Radical ◽  
Normal Serum ◽  
Joint Disease ◽  
Serum Samples ◽  
Rheumatoid Synovial Fluid ◽  
Gamma Radiolysis

Proton Hahn spin-echo n.m.r. spectroscopy was employed to detect abnormal metabolites present in rheumatoid synovial fluid that are derived from the deleterious generation of reactive oxygen radical species during exercise of the inflamed rheumatoid joint. A resonance attributable to a low-molecular-mass N-acetylglucosamine-containing oligosaccharide formed by the oxygen-radical-mediated depolymerization of synovial-fluid hyaluronate was clearly demonstrable when subjects with inflammatory joint disease were exercised. Moreover, formate, which may be derived from the attack of OH.radical on synovial-fluid carbohydrates, was also readily detectable in these samples. gamma-Radiolysis of rheumatoid synovial fluid samples and aqueous solutions of hyaluronate also gave rise to the production of the low-molecular-mass hyaluronate-derived oligosaccharide species and markedly elevated concentrations of (non-protein-bound) formate in the biological fluids. As expected, corresponding spectra of gamma-irradiated blood serum samples obtained from normal volunteers did not contain the signal attributable to the low-molecular-mass oligosaccharide species, but the formate resonance (barely detectable in non-irradiated normal serum samples) became clearly visible. Additionally, a curious increase in the effective concentration of non-protein-bound low-molecular-mass metabolites such as acetate, citrate, lactate and glutamine was observed after gamma-radiolysis of all biological fluids studied. The hyaluronate-derived low-molecular-mass oligosaccharide species and formate are suggested as novel markers of reactive oxygen radical activity in the inflamed rheumatoid joint during exercise-induced hypoxic/reperfusion injury.

scholarly journals Electrochemical biosensors in pharmaceutical analysis

2010 ◽  
Vol 46 (3) ◽  
pp. 375-391 ◽  
Author(s):  
Eric de Souza Gil ◽  
Giselle Rodrigues de Melo
Keyword(s):  
Pharmaceutical Analysis ◽  
Active Component ◽  
Electrochemical Sensors ◽  
Degradation Products ◽  
Biological Fluids ◽  
Low Cost ◽  
Analytical Techniques ◽  
Pharmaceutical Formulations ◽  
Quality Analysis ◽  
Increasing Demand

Given the increasing demand for practical and low-cost analytical techniques, biosensors have attracted attention for use in the quality analysis of drugs, medicines, and other analytes of interest in the pharmaceutical area. Biosensors allow quantification not only of the active component in pharmaceutical formulations, but also the analysis of degradation products and metabolites in biological fluids. Thus, this article presents a brief review of biosensor use in pharmaceutical analysis, focusing on enzymatic electrochemical sensors.

Recent Sensing Technologies for First Line Anti-Tuberculosis Drugs in Pharmaceutical Dosages and Biological Fluids: A Review

2019 ◽  
Vol 17 (11) ◽  
pp. 833-858
Author(s):  
Rajasekhar Chokkareddy ◽  
Gan G. Redhi
Keyword(s):  
Blood Plasma ◽  
Human Body ◽  
Electrochemical Sensors ◽  
Biological Fluids ◽  
Body Fluids ◽  
First Line ◽  
Pharmaceutical Samples ◽  
Global Problem ◽  
Voltammetric Techniques ◽  
Voltammetric Detection

Tuberculosis remains a global problem with a huge burden, estimated at 10.4 million new cases of infection in 2015. First line anti-tuberculosis drugs-based electrochemical sensors are being measured as an important development in the arenas of electroanalysis and are nowadays attracting the attention of several researchers. Transformation from classic electrochemical sensors which normally accept the complete value of the signal as the output, first line anti-tuberculosis drugs based electrochemical sensors retain dual electrochemical signals and the quantitative extent of target is based on the ratio of these two signals. Electrochemical methods have integral benefits over other well-established analytical procedures, this review pointing to offer an efficient summary of the newest developments in the voltammetric detection of anti-tuberculosis drugs. Moreover, the advantages and limits of these approaches are critically discussed and deliberated. The review exposes that in spite of exhausting a variation of chemically fabricated electrodes to isolate the first line anti-tuberculosis drugs, there is still a deficiency of applicability of the voltammetric techniques to measure these complexes in human body fluids, exclusively in blood plasma and pharmaceutical samples as well.

Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage

1992 ◽  
Vol 82 (3) ◽  
pp. 315-320 ◽  
Author(s):  
John M. C. Gutteridge
Keyword(s):  
Cerebrospinal Fluid ◽  
Molecular Mass ◽  
Binding Capacity ◽  
Biological Fluids ◽  
Oxidant Stress ◽  
Ferrous Ions ◽  
Ferroxidase Activity ◽  
Anti Oxidant ◽  
Low Levels ◽  
Iron Binding Capacity

1. During pathological states of iron-overload or oxidant stress, low-molecular-mass iron can become available within extracellular fluids. 2. This iron would be converted to the ferrous state were it not for the protective anti-oxidant protein caeruloplasmin. 3. The ferrous-ion-oxidizing activity of caeruloplasmin rapidly converts ferrous ions back to the less reactive ferric state so that they can bind to available binding sites on transferrin. 4. Cerebrospinal fluids, however, often appear to contain low-molecular-mass iron, high levels of ascorbate and low levels of ferroxidase activity with little or no iron-binding capacity. 5. When iron ions are present in cerebrospinal fluid they are therefore likely to be in the ferrous state. 6. The development and application of an assay to speciate and measure ferrous ions in simple aqueous solution and their redox cycling activity in biological fluids is described.

scholarly journals Carbon nanomaterials: synthesis and applications to development of electrochemical sensors in determination of drugs and compounds of clinical interest

2020 ◽  
Vol 38 (3) ◽  
Author(s):  
Laís S. Porto ◽  
Daniela N. Silva ◽  
Ana Elisa F. de Oliveira ◽  
Arnaldo C. Pereira ◽  
Keyller B. Borges
Keyword(s):  
Carbon Nanomaterials ◽  
Electrochemical Sensors ◽  
Biological Fluids ◽  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Synthesis Methods ◽  
Electrocatalytic Effect ◽  
Clinical Interest

AbstractIt is notorious that researches related to electrochemical sensors increased significantly due the promising characteristics that these devices present such as the possibility of obtaining information, with minimum manipulation of the studied system, in real time, and with low environmental impact. This article covers the carbon nanomaterials, presenting important aspects such as main properties, synthesis methods, and the application of these materials in the development of electrochemical sensors for the analysis of drugs and compounds of clinical interest. In this context, drug analysis is extremely important for quality control, to ensure that the medicine fulfills its role effectively without possible complications that could compromise the patient’s health and quality of life. In addition, analytical methods capable of determining compounds of clinical interest in biological fluids are extremely important for the indication of effective diagnoses. Thus, the versatility, selectivity, and portability of the electroanalytical techniques make the electrochemical sensors a favorite tool for the determination of drugs and compounds of clinical interest. It will be possible to follow in the present work that carbon nanomaterials have excellent thermal and electrical conductivity, strong adsorption capacity, high electrocatalytic effect, high biocompatibility, and high surface area. The possibility of formation of different composite materials based on carbonaceous nanomaterials that makes these materials promising for the development of analytical sensors, contributing to rapid, sensitive, and low-cost analyses can also be highlighted.

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