Voltammetric behavior of HeLa cells on a carbon nanotube/ionic liquid modified electrode for cytotoxicity evaluation of chlorophenols

2016 ◽  
Vol 8 (1) ◽  
pp. 171-176 ◽  
Author(s):  
Xiaolin Zhu ◽  
Hongwei Qin ◽  
Guanlan Wu ◽  
Jinlian Li ◽  
Xing Yuan ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Carbon Nanotube ◽  
Modified Electrode ◽  
Cervical Carcinoma ◽  
Hela Cells ◽  
Electrochemical Method ◽  
Purine Metabolism ◽  
Human Cervical Carcinoma ◽  
Voltammetric Behavior

Two voltammetric signals based on the purine metabolism of human cervical carcinoma (HeLa) cells on a sensitive p-MWCNT/IL/GCE was discovered. The cytotoxicity of three chlorophenols was tested with this double-signal electrochemical method.

scholarly journals Cytotoxic activity of proteins isolated from extracts of Corydalis cava tubers in human cervical carcinoma HeLa cells

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Robert Nawrot ◽  
Maria Wolun-Cholewa ◽  
Wojciech Bialas ◽  
Danuta Wyrzykowska ◽  
Stanislaw Balcerkiewicz ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cervical Carcinoma ◽  
Hela Cells ◽  
Human Cervical Carcinoma

Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells

2009 ◽  
Vol 87 (6) ◽  
pp. 933-942 ◽  
Author(s):  
Li Yang ◽  
Hai-wei Zhang ◽  
Rong Hu ◽  
Yong Yang ◽  
Qi Qi ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Cervical Carcinoma ◽  
Hela Cells ◽  
Therapeutic Potential ◽  
P53 Gene ◽  
Mrna Levels ◽  
Human Cervical Carcinoma ◽  
Phase Arrest

Wogonin, a naturally occurring flavonoid, has been shown to have tumor therapeutic potential both in vitro and in vivo. To better understand its anticancer mechanism, we examined the effect of wogonin on human cervical carcinoma HeLa cells. In this study, we observed that G1 phase arrest was involved in wogonin-induced growth inhibition in HeLa cells. Over a 24 h exposure of HeLa cells to 90 µmol·L–1 wogonin, the promoters of G1–S transition, including cyclin D1/Cdk4 and pRb, decreased within 12 h and E2F-1 depleted in the nucleus at the same time. As the G1 phase arrest developed, p53 and the Cdk inhibitor p21Cip1 elevated both at protein and mRNA levels. Furthermore, the up-regulation of p21Cip1 induced by wogonin was dramatically inhibited by siRNA-mediated p53 gene silencing. Collectively, our data suggested that wogonin induced G1 phase arrest in HeLa cells by modulating several key G1 regulatory proteins, such as Cdk4 and cyclin D1, as well as up-regulation of a p53-midiated p21Cip1 expression. This mechanism of wogonin may play an important role in the killing of cancerous cells and offer a potential mechanism for its anticancer action in vivo.

P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells

2012 ◽  
Vol 46 (9) ◽  
pp. 1082-1092 ◽  
Author(s):  
Simiao Fan ◽  
Yang Yu ◽  
Min Qi ◽  
Zhongdong Sun ◽  
Lihua Li ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Hela Cells ◽  
Human Cervical Carcinoma

Effect of aspirin alone or combined with cisplatin on human cervical carcinoma HeLa cells

2010 ◽  
Vol 25 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Wang Yueling ◽  
Zhao Hongmin ◽  
Liu Lin ◽  
Wang Jiangfen
Keyword(s):  
Cervical Carcinoma ◽  
Hela Cells ◽  
Human Cervical Carcinoma
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