Determination and pharmacokinetic study of kaempferide in rat plasma by UPLC

2015 ◽  
Vol 7 (24) ◽  
pp. 10238-10242
Author(s):  
Song-Feng Lv ◽  
Xiang-Hong Wang ◽  
Bo Wang ◽  
Hong-Wei Li ◽  
Xiao-Lei Zhang ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Pharmacokinetic Study ◽  
Analytical Method ◽  
Internal Standard ◽  
Ultra Performance Liquid Chromatography ◽  
Rat Plasma

In this study, a simple, sensitive, and robust analytical method based on ultra-performance liquid chromatography (UPLC) has been developed for the determination of kaempferide in rat plasma using diazepam as the internal standard (IS).

Simultaneous determination of ivabradine, metoprolol and their metabolites in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry and its application in a pharmacokinetic study

2015 ◽  
Vol 7 (19) ◽  
pp. 8459-8465 ◽  
Author(s):  
Wei Sun ◽  
Ruimin Chen ◽  
Wanshu Li ◽  
Hui Zhang ◽  
Jifeng Ye ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Pharmacokinetic Study ◽  
Ultra Performance Liquid Chromatography ◽  
Rat Plasma ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

A sensitive and rapid UPLC-MS/MS method was developed to determine ivabradine, metoprolol and their corresponding metabolites in rat plasma simultaneously.

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