Simultaneous quantitation of nine kinds of (d)- and (l)-amino acid enantiomers by HPLC-MS/MS: application to the quality control of amino acid tablets

2015 ◽  
Vol 7 (20) ◽  
pp. 8817-8825 ◽  
Author(s):  
Xiaoyan Li ◽  
Yan Cui ◽  
Yuping Xing ◽  
Chunxiao Lv ◽  
Qing Li ◽  
...  
Keyword(s):  
Quality Control ◽  
Amino Acid ◽  
Simultaneous Determination ◽  
Amino Acid Enantiomers

A HPLC-MS/MS method was developed for the simultaneous determination of nine kinds of (d)- and (l)-amino acid enantiomers and applied to control the quality of amino acid tablets.

Simultaneous Determination of Eight Potential Q-Markers in Zishen Tongguan Capsules Based on UHPLC-MS/MS

2020 ◽  
Vol 17 (1) ◽  
pp. 47-56
Author(s):  
Shun Liu ◽  
Xun Wang ◽  
Kaiping Zou ◽  
Wei Liu ◽  
Cunyu Li ◽  
...  
Keyword(s):  
Quality Control ◽  
Chinese Medicine ◽  
Simultaneous Determination ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Gradient Elution ◽  
Quality Markers ◽  
High Repeatability ◽  
Comprehensive Study

Background: Zishen Tongguan (ZSTG) capsules were prepared at the Affiliated Hospital of Nanjing University of Chinese Medicine and have been proven to be clinically effective for treating pyelonephritis and benign prostatic hyperplasia. However, the quality standards are not ideal; a comprehensive study of the “quality markers” (Q-markers), the chemicals inherent in traditional Chinese medicine and its preparations, has not been carried out. Experimental Methods: In this paper, a sensitive and specific ultra-high-performance liquid chromatographictandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of eight potential Q-markers of ZSTG, including timosaponin A3, berberine, jatrorrhizine, phellodendrine, palmatine, mangiferin, neomangiferin, and timosaponin BII. A Kromasil 100-3.5 C18 column was used with a mobile phase of 0.2% formic acid with acetonitrile, and gradient elution at a flow rate of 0.2 mL/min was achieved in 13 minutes and used for separation. Detection was performed in positive/negative mode with multiple reaction monitoring (MRM). Results: The analytical method was validated in terms of the sensitivity, linearity, accuracy, precision, repeatability, stability and recovery. The method established here was successfully applied to study the potential Q-markers in 8 batches of commercial samples, which demonstrated its use in improving the quality control of ZSTG. Conclusion: The developed method had high repeatability and accuracy and was suitable for the simultaneous analysis of multiple Q-markers, which may provide a new basis for the comprehensive assessment and overall quality control of ZSTG.

Determination of amino acid enantiomers by two-column gas chromatography with valveless column switching

1983 ◽  
Vol 262 ◽  
pp. 352-359 ◽  
Author(s):  
Chinghai Wang ◽  
Hartmut Frank ◽  
Guanghua Wang ◽  
Liangmo Zhou ◽  
Ernst Bayer ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Amino Acid ◽  
Column Switching ◽  
Amino Acid Enantiomers

scholarly journals Determination of gas-saturated oil density at reservoir conditions and development of quality control index of PVT laboratory report

2020 ◽  
Author(s):  
Muhammad Ali Al-Marhoun
Keyword(s):  
Quality Control ◽  
Production Engineering ◽  
Accuracy Estimate ◽  
Bubble Point ◽  
Laboratory Report ◽  
Reservoir Conditions ◽  
Data Yield ◽  
Oil Density

AbstractThe oil density at the bubble point is an important thermodynamic property required in reservoir simulation and production engineering. A higher-accuracy estimate of this property would improve the accuracy of reservoir and production engineering calculations. The bubble point oil density is obtained either from separator tests of reservoir fluids or from differential gas liberation tests. A new procedure utilizing separator and differential tests is proposed whereby the experimental data yield a unique value with high accuracy for the bubble point oil density. A consistent correction of other PVT properties, which are influenced by the bubble point oil density, is required to reflect the unique density value. A quantitative quality control index is defined to measure the quality of PVT laboratory reports. This is achieved by utilizing the unique property of the bubble point oil density, which is usually ignored.

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