The development of paper microfluidic devices for presumptive drug detection

2015 ◽  
Vol 7 (19) ◽  
pp. 8025-8033 ◽  
Author(s):  
Giacomo Musile ◽  
Ling Wang ◽  
Jashaun Bottoms ◽  
Franco Tagliaro ◽  
Bruce McCord
Keyword(s):  
Microfluidic Device ◽  
Colorimetric Detection ◽  
Microfluidic Devices ◽  
Drug Detection ◽  
Paper Microfluidic

Colorimetric detection of morphine on a 6 channel paper microfluidic device.

scholarly journals Citizen-Led Sampling to Monitor Phosphate Levels in Freshwater Environments Using a Simple Paper Microfluidic Device

2021 ◽  
Author(s):  
Samantha Richardson ◽  
Alexander Iles ◽  
Jeanette M. Rotchell ◽  
Tim Charlson ◽  
Annabel Hanson ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Mobile Technology ◽  
High Frequency ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Smartphone App ◽  
Test Device ◽  
Monitoring Campaign ◽  
Paper Microfluidic ◽  
Freshwater Environments

We demonstrate how a combination of paper microfluidic devices and handheld mobile technology can be used by citizen scientists to carry out a sustained water monitoring campaign. We have developed a paper-based analysis device and a 3 minute sampling workflow that requires no more than a container, a test device and a smartphone app. The contaminant measured in these pilots are phosphates, detectable down to 3 mg L<sup>-1</sup>. Together these allow volunteers to successfully carry out cost-effective, high frequency, phosphate monitoring over an extended geographies and periods.

Colorimetric analysis of the decomposition of S-nitrosothiols on paper-based microfluidic devices

The Analyst ◽  
2016 ◽  
Vol 141 (22) ◽  
pp. 6314-6320 ◽  
Author(s):  
Abdulghani Ismail ◽  
Marillya O. Araújo ◽  
Cyro L. S. Chagas ◽  
Sophie Griveau ◽  
Fanny D'Orlyé ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Colorimetric Analysis ◽  
Paper Microfluidic

A disposable paper microfluidic device was developed to analyse different S-nitrosothiols simultaneously decomposed by Hg2+ as well as UV, Vis and IR lamps.

Highly sensitive colorimetric detection of glucose and uric acid in biological fluids using chitosan-modified paper microfluidic devices

The Analyst ◽  
2016 ◽  
Vol 141 (15) ◽  
pp. 4749-4756 ◽  
Author(s):  
Ellen F. M. Gabriel ◽  
Paulo T. Garcia ◽  
Thiago M. G. Cardoso ◽  
Flavio M. Lopes ◽  
Felipe T. Martins ◽  
...  
Keyword(s):  
Uric Acid ◽  
Biological Fluids ◽  
Colorimetric Detection ◽  
Microfluidic Devices ◽  
Analytical Performance ◽  
Highly Sensitive ◽  
Colorimetric Measurements ◽  
Paper Microfluidic ◽  
Enzymatic Bioassays

This paper describes the modification of microfluidic paper-based analytical devices (μPADs) with chitosan to improve the analytical performance of colorimetric measurements associated with enzymatic bioassays.

scholarly journals Correction: The development of paper microfluidic devices for presumptive drug detection

2015 ◽  
Vol 7 (20) ◽  
pp. 8977-8977
Author(s):  
Giacomo Musile ◽  
Ling Wang ◽  
Jashaun Bottoms ◽  
Franco Tagliaro ◽  
Bruce McCord
Keyword(s):  
Microfluidic Devices ◽  
Drug Detection ◽  
Paper Microfluidic

Correction for ‘The development of paper microfluidic devices for presumptive drug detection’ by Giacomo Musile et al., Anal. Methods, 2015, DOI: 10.1039/c5ay01432h.

scholarly journals Simple monitoring of pH and urea in whole blood using wearable smart woman pad

Bioimpacts ◽  
2020 ◽  
Author(s):  
Bambang Kuswandi ◽  
Nur Andriani ◽  
Ari S Nugraha
Keyword(s):  
Blood Cell ◽  
Microfluidic Device ◽  
Red Blood Cell ◽  
Whole Blood ◽  
Color Change ◽  
Clinical Laboratory ◽  
Limit Of Detection ◽  
Colorimetric Detection ◽  
Real Samples ◽  
Paper Microfluidic

Introduction: In this work, we used a thread-paper microfluidic device (μTPAD) system, where a threaded part for the handling of the whole blood samples and a paper part for the reaction of plasma with immobilized bioreagents integrated into woman pad as a wearable sensing device namely as smart women pad. The μTPAD as a wearable smart woman pad is developed for the detection of pH and urea in mensuration blood as real samples. Methods: This combined device was constructed to cover the elements required, that is, separation of red blood cell, conditioning, analyte reaction, and colorimetric detection. The color change in sensing areas was measured in the RGB values via a smartphone using the Color Grab after a smart woman pad was used. The thread allowed red blood cell sampling and separation, while the paper microfluidic device was used for conditioning, biorecognition, and colorimetric transduction of pH and urea as analytes. Results: The time needed for analysis was measured as 110 s using the equilibrium method for both analytes, with a limit of detection (LOD) of 72.55 μg/mL for urea, with precision around 1.68%, while for pH around 0.80%. The smart woman pad allowed rapid detection of pH and urea in menstruation blood as real samples for monitoring of the kidney functions, and the results showed an agreement with the conventional methods that have been generally used in the clinical laboratory. Conclusion: The smart woman pad has the potential to be used as a wearable device to monitor the health status of the user via its blood mensuration analysis.

scholarly journals Citizen-Led Sampling to Monitor Phosphate Levels in Freshwater Environments Using a Simple Paper Microfluidic Device

2021 ◽  
Author(s):  
Samantha Richardson ◽  
Alexander Iles ◽  
Jeanette M. Rotchell ◽  
Tim Charlson ◽  
Annabel Hanson ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Mobile Technology ◽  
High Frequency ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Smartphone App ◽  
Test Device ◽  
Monitoring Campaign ◽  
Paper Microfluidic ◽  
Freshwater Environments

We demonstrate how a combination of paper microfluidic devices and handheld mobile technology can be used by citizen scientists to carry out a sustained water monitoring campaign. We have developed a paper-based analysis device and a 3 minute sampling workflow that requires no more than a container, a test device and a smartphone app. The contaminant measured in these pilots are phosphates, detectable down to 3 mg L<sup>-1</sup>. Together these allow volunteers to successfully carry out cost-effective, high frequency, phosphate monitoring over an extended geographies and periods.

Fabrication of fully enclosed paper microfluidic devices using plasma deposition and etching

Lab on a Chip ◽  
2019 ◽  
Vol 19 (19) ◽  
pp. 3337-3343 ◽  
Author(s):  
N. Raj ◽  
V. Breedveld ◽  
D. W. Hess
Keyword(s):  
Microfluidic Device ◽  
Plasma Etching ◽  
Plasma Deposition ◽  
Microfluidic Devices ◽  
Paper Microfluidic

A fully enclosed paper microfluidic device has been fabricated using pentafluoroethane (PFE) plasma deposition followed by O2 plasma etching.

scholarly journals Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 387
Author(s):  
Carlos Toshiyuki Matsumi ◽  
Wilson José da Silva ◽  
Fábio Kurt Schneider ◽  
Joaquim Miguel Maia ◽  
Rigoberto E. M. Morales ◽  
...  
Keyword(s):  
Electric Fields ◽  
Microfluidic Device ◽  
Soft Lithography ◽  
Low Cost ◽  
Characteristic Curve ◽  
Microfluidic Devices ◽  
Average Diameter ◽  
Internal Diameter ◽  
Medical Diagnostic ◽  
Average Size

Microbubbles have various applications including their use as carrier agents for localized delivery of genes and drugs and in medical diagnostic imagery. Various techniques are used for the production of monodisperse microbubbles including the Gyratory, the coaxial electro-hydrodynamic atomization (CEHDA), the sonication methods, and the use of microfluidic devices. Some of these techniques require safety procedures during the application of intense electric fields (e.g., CEHDA) or soft lithography equipment for the production of microfluidic devices. This study presents a hybrid manufacturing process using micropipettes and 3D printing for the construction of a T-Junction microfluidic device resulting in simple and low cost generation of monodisperse microbubbles. In this work, microbubbles with an average size of 16.6 to 57.7 μm and a polydispersity index (PDI) between 0.47% and 1.06% were generated. When the device is used at higher bubble production rate, the average diameter was 42.8 μm with increased PDI of 3.13%. In addition, a second-order polynomial characteristic curve useful to estimate micropipette internal diameter necessary to generate a desired microbubble size is presented and a linear relationship between the ratio of gaseous and liquid phases flows and the ratio of microbubble and micropipette diameters (i.e., Qg/Ql and Db/Dp) was found.

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