Simultaneous determination of 41 components in Gualou Guizhi granules by UPLC coupled with triple quadrupole mass spectrometry

2015 ◽  
Vol 7 (19) ◽  
pp. 8285-8296 ◽  
Author(s):  
Yu Lin ◽  
Wei Xu ◽  
Wen Xu ◽  
Mingqing Huang ◽  
Yuqin Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Classical Formula ◽  
Cord Injury

Gualou Guizhi granules (GLGZGs) are a classical formula of traditional Chinese medicine, which have been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury.

scholarly journals Research progress in use of traditional Chinese medicine for treatment of spinal cord injury

2020 ◽  
Vol 127 ◽  
pp. 110136 ◽  
Author(s):  
Yubao Lu ◽  
Jingjing Yang ◽  
Xuexi Wang ◽  
Zhanjun Ma ◽  
Sheng Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Research Progress ◽  
Cord Injury

scholarly journals Therapeutic Effects of Traditional Chinese Medicine on Spinal Cord Injury: A Promising Supplementary Treatment in Future

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Qian Zhang ◽  
Hao Yang ◽  
Jing An ◽  
Rui Zhang ◽  
Bo Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Epigallocatechin Gallate ◽  
Therapeutic Effects ◽  
Cord Injury ◽  
Supplementary Treatment ◽  
Natural Drugs ◽  
Doctoral Dissertations

Objective. Spinal cord injury (SCI) is a devastating neurological disorder caused by trauma. Pathophysiological events occurring after SCI include acute, subacute, and chronic phases, while complex mechanisms are comprised. As an abundant source of natural drugs, Traditional Chinese Medicine (TCM) attracts much attention in SCI treatment recently. Hence, this review provides an overview of pathophysiology of SCI and TCM application in its therapy.Methods. Information was collected from articles published in peer-reviewed journals via electronic search (PubMed, SciFinder, Google Scholar, Web of Science, and CNKI), as well as from master’s dissertations, doctoral dissertations, and Chinese Pharmacopoeia.Results. Both active ingredients and herbs could exert prevention and treatment against SCI, which is linked to antioxidant, anti-inflammatory, neuroprotective, or antiapoptosis effects. The detailed information of six active natural ingredients (i.e., curcumin, resveratrol, epigallocatechin gallate, ligustrazine, quercitrin, and puerarin) and five commonly used herbs (i.e., Danshen, Ginkgo, Ginseng, Notoginseng, and Astragali Radix) was elucidated and summarized.Conclusions. As an important supplementary treatment, TCM may provide benefits in repair of injured spinal cord. With a general consensus that future clinical approaches will be diversified and a combination of multiple strategies, TCM is likely to attract greater attention in SCI treatment.

Rapid and Sensitive Determination of 13 Components in a Traditional Chinese Medicine Formula of Da-Huang-Gan-Cao Decoction by High-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry

2017 ◽  
Vol 100 (5) ◽  
pp. 1428-1433
Author(s):  
Jialin Qu ◽  
Nan Xiao ◽  
Hua Sui ◽  
Lina Liang ◽  
Jing Chen ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
High Performance ◽  
Gradient Elution ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Test Range ◽  
Chinese Medicine Formula ◽  
Sensitive Determination

Abstract Da-Huang-Gan-Cao decoction (DHGCD), which is a classic formula in traditional Chinese medicine, has been clinically used for the treatment of vomiting, constipation, pancreatitis, and cholelithiasis in China and Japan. In this study, a rapid and validated method using HPLC coupled with triple quadrupole MS was developed for the simultaneous determination of 13 components in DHGCD. Separation was performed on an XBridge BEH C18 column (50 × 2.1 mm, 2.5 μm) with a gradient elution of acetonitrile and0.1% formic acid in water. All calibration curves showed good linear regression (r > 0.9981) within the test range. LODs and LOQs were in the range of 1.0–20 and 2.6–69 ng/mL, respectively. The proposed method was applied for the analysis of the target compounds in 10 batches of DHGCD within a total time of 10 min. This method was conducive for the QC of DHGCD.

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