An arylboronate-based fluorescent probe for peroxynitrite with fast response and high selectivity

2015 ◽  
Vol 7 (12) ◽  
pp. 4885-4888 ◽  
Author(s):  
Jian Zhang ◽  
Yaping Li ◽  
Wei Guo
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
Fast Response

An arylboronate-based fluorescent probe was developed for detecting peroxynitrite in vitro and in vivo with fast response and high selectivity.

A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85957-85963 ◽  
Author(s):  
Peng Wang ◽  
Ke Wang ◽  
Dan Chen ◽  
Yibo Mao ◽  
Yueqing Gu
Keyword(s):  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Near Infrared

A novel NIR fluorescent probe (DCM-B2) based on dicyanomethylene-4H-pyran was synthesized for the detection of H2O2.

scholarly journals Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides

2020 ◽  
Author(s):  
Jinming Guan ◽  
Christina Spry ◽  
Erick T. Tjhin ◽  
Penghui Yang ◽  
Tanakorn Kittikool ◽  
...  
Keyword(s):  
Contact Time ◽  
High Selectivity ◽  
Amide Group ◽  
Antiplasmodial Activity ◽  
Time Data ◽  
Facile Synthesis ◽  
Isoxazole Derivative ◽  
Nanomolar Range

ABSTRACTThe Plasmodium parasites that cause malaria are adept at developing resistance to antimalarial drugs, necessitating the search for new antiplasmodials. Although several amide analogs of pantothenate (pantothenamides) show potent antiplasmodial activity, hydrolysis by pantetheinases (or vanins) present in blood rapidly inactivates them. We report herein the facile synthesis and biological activity of a small library of pantothenamide analogs in which the labile amide group is replaced with a variety of heteroaromatic rings. Several of the new analogs display antiplasmodial activity in the nanomolar range against P. falciparum and/or P. knowlesi in the presence of pantetheinase. A previously reported triazole and an isoxazole derivative presented here were further characterized and found to possess high selectivity indices, medium or high Caco-2 permeability, and medium or low microsomal clearance in vitro. Although we show here that the two compounds fail to suppress proliferation of P. berghei in vivo, pharmacokinetic and contact time data presented provide a benchmark for the compound profile required to achieve antiplasmodial activity in mice and should facilitate lead optimization.

A ratiometric fluorescence sensor for HOCl based on a FRET platform and application in living cells

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17059-17063 ◽  
Author(s):  
Yan-Ru Zhang ◽  
Zhi-Min Zhao ◽  
Le Su ◽  
Jun-Ying Miao ◽  
Bao-Xiang Zhao
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
Fast Response ◽  
Living Cells ◽  
Fluorescence Sensor ◽  
Ratiometric Fluorescence ◽  
Ratiometric Fluorescent Probe

A ratiometric fluorescent probe CRSH based on a FRET platform for detecting HOCl. CRSH showed high selectivity, excellent sensitivity and a fast response toward HOCl.

A thiazolo[4,5-b]pyridine-based fluorescent probe for detection of zinc ions and application for in vitro and in vivo bioimaging

Talanta ◽  
2018 ◽  
Vol 185 ◽  
pp. 396-404 ◽  
Author(s):  
Jiao Gong ◽  
Yuan-heng Li ◽  
Chan-juan Zhang ◽  
Jian Huang ◽  
Qi Sun
Keyword(s):  
Fluorescent Probe ◽  
Zinc Ions

The development of a hemicyanine-based ratiometric CO fluorescent probe with a long emission wavelength and its applications for imaging CO in vitro and in vivo

2020 ◽  
Vol 44 (28) ◽  
pp. 12107-12112 ◽  
Author(s):  
Yunyan Zhang ◽  
Xiuqi Kong ◽  
Yonghe Tang ◽  
Min Li ◽  
Yaguang Yin ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Living Cells ◽  
Emission Wavelength ◽  
Long Wavelength ◽  
Wavelength Emission ◽  
Ratiometric Fluorescent Probe

A novel ratiometric fluorescent probe, Hcy-CO, with long-wavelength emission was developed for visualizing CO in living cells and zebrafish.

Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo

The Analyst ◽  
2019 ◽  
Vol 144 (12) ◽  
pp. 3807-3816 ◽  
Author(s):  
Xiaojun He ◽  
Chenglin Wu ◽  
Yuna Qian ◽  
Yahui Li ◽  
Lilei Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Chromium Ions ◽  
Highly Sensitive ◽  
Bio Imaging

Here reported an NBDT sensor could be effectively responsive to gallium and chromium for bio-imaging in vivo.

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