Investigation of antimalarial drug pyrimethamine and its interaction with dsDNA by electrochemical and spectroscopic techniques

2015 ◽  
Vol 7 (10) ◽  
pp. 4159-4167 ◽  
Author(s):  
Abd-Elgawad Radi ◽  
Hossam M. Nassef ◽  
Mohamed I. Attallah
Keyword(s):  
Cyclic Voltammetry ◽  
Differential Pulse Voltammetry ◽  
Electrochemical Behavior ◽  
Antimalarial Drug ◽  
Differential Pulse ◽  
Spectroscopic Techniques ◽  
Carbon Electrode ◽  
Screen Printed Carbon Electrode ◽  
Pulse Voltammetry ◽  
Screen Printed

The electrochemical behavior of the antimalarial drug pyrimethamine (PMT) was examined at a screen printed carbon electrode (SPCE) in different aqueous supporting electrolytes using cyclic voltammetry (CV) and differential pulse voltammetry (DPV).

scholarly journals MODIFIKASI SPCE (SCREEN PRINTED CARBON ELECTRODE) DENGAN PEDOT-PSS (POLY (3,4-ETHYLENEDIOXYTHIOPHENE) POLY (STYRENE SULFONIC ACID)) UNTUK PENENTUAN FENOL

2020 ◽  
Vol 1 (1) ◽  
pp. 39-45
Author(s):  
Farahdilla Andhika
Keyword(s):  
Differential Pulse Voltammetry ◽  
Sulfonic Acid ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Screen Printed Carbon Electrode ◽  
Pulse Voltammetry ◽  
Styrene Sulfonic Acid ◽  
Screen Printed

Pada penelitian ini, modifikasi Screen Printed Carbon Electrode (SPCE) secara fisik dilakukan dengan menggunakan poly (3,4-ethylenedioxythiophene) -poly (styrene sulfonic acid) (PEDOT-PSS) untuk meningkatkan sensitivitas penentuan fenol secara voltametri. Pengukuran fenol dilakukan dengan metode differential pulse voltammetry (DPV) pada kisaran potensial -0,5 sampai 1 Volt, durasi 180 detik, potensial deposisi -0,5 Volt, dan kecepatan penyapuan 100 mV/s pada pH 6-9, rentang konsentrasi fenol 0-100 mikro M, serta konsentrasi PEDOT-PSS sebesar 0-100%. Berdasarkan hasil penelitian, peningkatan konsentrasi PEDOT-PSS berpengaruh terhadap respon arus. Kondisi optimum dicapai pada pH 8 dengan konsentrasi PEDOT-PSS 50%, sensitivitas sebesar 0.009 mikro A/mikro M dengan batas deteksi 0.1595 mikro M.

scholarly journals 3A-Amino-3A-Deoxy-(2AS, 3AS)-β-Cyclodextrin Hydrate/Tin Disulfide Modified Screen-Printed Carbon Electrode for the Electrochemical Detection of Polychlorinated Biphenyls

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Xinke Liu ◽  
Rajalakshmi Sakthivel ◽  
Chia-Yin Cheng ◽  
Jiangliu Luo ◽  
Lijun Song ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Detection Range ◽  
Tin Disulfide ◽  
Screen Printed Carbon Electrode ◽  
Endocrine Disrupting ◽  
Pulse Voltammetry ◽  
Limit Detection ◽  
Screen Printed

AbstractPolychlorinated biphenyls (PCBs) are persistent organic pollutants that are widely distributed in the environment. It is noteworthy that the PCBs are endocrine-disrupting substances, and their toxicity induces cancer and damage to the mammalian reproductive system, immune system, stomach, skin, liver, etc. This work aimed to synthesize 3A-amino-3A-deoxy-(2AS, 3AS)-β-cyclodextrin hydrate/tin disulfide composite material and to study its material properties, electrochemical properties, and application to PCB detection. The nanostructured tin disulfide (SnS2) synthesized by hydrothermal technique and 3A-amino-3A-deoxy-(2AS, 3AS)-β-cyclodextrin hydrate were sequentially modified onto the disposable screen-printed carbon electrode (SPCE) via titration using a micropipette. The 3A-amino-3A-deoxy-(2AS, 3AS)-β-cyclodextrin hydrate (β-CD) improved the selectivity of the modified electrode. The fabricated β-CD/SnS2/SPCE was employed to determine the presence of PCBs by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The detection range was 0.625–80 μM, with a limit detection of approximately 5 μM. The electrodes were as stable as 88% after 7 days’ storage. The results showed that the β-CD successfully encapsulated PCBs to achieve an electrochemical sensor that reduced the time and increased the convenience of PCBs detection.

Electrochemical characterization of luminol and its determination in real samples

2014 ◽  
Vol 6 (19) ◽  
pp. 7809-7813 ◽  
Author(s):  
Gulcemal Yildiz ◽  
Ugur Tasdoven ◽  
Necati Menek
Keyword(s):  
Cyclic Voltammetry ◽  
Glassy Carbon ◽  
Electrochemical Behavior ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Buffer Solution ◽  
Solution Ph ◽  
Real Samples ◽  
Pulse Voltammetry

The electrochemical behavior of luminol, an important molecule in forensic science, was studied in Britton–Robinson buffer solution (pH 2–pH 13) at a glassy carbon electrode using cyclic voltammetry and differential pulse voltammetry techniques.

scholarly journals Penentuan Hidrokuinon dalam Sampel Krim Pemutih Wajah secara Voltammetri Menggunakan Screen Printed Carbon Electrode (SPCE)

2015 ◽  
pp. 97-102
Author(s):  
Ani Mulyasuryani ◽  
Alfita Savitri
Keyword(s):  
Limit Of Detection ◽  
Differential Pulse ◽  
Electrode System ◽  
Carbon Electrode ◽  
Peak Potential ◽  
Screen Printed Carbon Electrode ◽  
The Face ◽  
High Pulse ◽  
Pulse Voltammetry ◽  
Screen Printed

Hydroquinone in whitening face cream has been banned since 2008, but is still found facial bleaching creams containing hydroquinone. Therefore, in this study have been developed voltammetric method for the determination hydroquinone in face whitening cream. This study has been carried out optimization of pH and measurement conditions. Optimizationof pH has been done in cyclic voltammetry, while the optimization of measurement carried out by differential pulse voltammetry. In this study, using a screen printed carbon electrode with a three electrode system. The results showed that the increase in pH causes a decrease in the anodic peak potential (Epa) of hydroquinone. The optimum conditions resulted at pH 2 in which the anodic current (Ipa) is the highest. The optimum condition resulted at high pulse 200 mV and scan rate at 15 mV/sec. The linear regression concentration is 1-100 μM, limit of detection is 0.015 μM and sensitivity is 0.0652 μM/µA. The results showed that the concentration of hydroquinone in the face whitening cream samples ranged from 0 to 0.02%DOI :http://dx.doi.org/10.15408/jkv.v0i0.3145.

Solar Exfoliated Graphene Oxide: A Platform for Electrochemical Sensing of Epinephrine

2020 ◽  
Vol 16 (4) ◽  
pp. 393-403 ◽  
Author(s):  
Renjini Sadhana ◽  
Pinky Abraham ◽  
Anithakumary Vidyadharan
Keyword(s):  
Cyclic Voltammetry ◽  
Graphene Oxide ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Simultaneous Detection ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Reduced Graphene ◽  
Pulse Voltammetry

Introduction: In this study, solar exfoliated graphite oxide modified glassy carbon electrode was used for the anodic oxidation of epinephrine in a phosphate buffer medium at pH7. The modified electrode showed fast response and sensitivity towards Epinephrine Molecule (EP). The electrode was characterized electrochemically through Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV). Area of the electrode enhanced three times during modification and studies reveal that the oxidation process of EP occurs by an adsorption controlled process involving two electrons. The results showed a detection limit of 0.50 ± 0.01μM with a linear range up to 100 μM. The rate constant calculated for the electron transfer reaction is 1.35 s-1. The electrode was effective for simultaneous detection of EP in the presence of Ascorbic Acid (AA) and Uric Acid (UA) with well-resolved signals. The sensitivity, selectivity and stability of the sensor were also confirmed. Methods: Glassy carbon electrode modified by reduced graphene oxide was used for the detection and quantification of epinephrine using cyclic voltammetry and differential pulse voltammetry. Results: The results showed an enhancement in the electrocatalytic oxidation of epinephrine due to the increase in the effective surface area of the modified electrode. The anodic transfer coefficient, detection limit and electron transfer rate constant of the reaction were also calculated. Conclusion: The paper reports the determination of epinephrine using reduced graphene oxide modified glassy carbon electrode through CV and DPV. The sensor exhibited excellent reproducibility and repeatability for the detection of epinephrine and also its simultaneous detection of ascorbic acid and uric acid, which coexist in the biological system.

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