scholarly journals Label-free detection of missense mutations and methylation differences in the p53 gene using optically diffracting hydrogels

The Analyst ◽  
2015 ◽  
Vol 140 (18) ◽  
pp. 6354-6362 ◽  
Author(s):  
Kelsey I. MacConaghy ◽  
Duncan M. Chadly ◽  
Mark P. Stoykovich ◽  
Joel L. Kaar
Keyword(s):  
Photonic Crystal ◽  
Optical Detection ◽  
P53 Gene ◽  
Epigenetic Modifications ◽  
Missense Mutations ◽  
Label Free ◽  
Novel Approach ◽  
Label Free Detection ◽  
Hydrogel Films

A novel approach for the optical detection of DNA was developed via polymerization of a photonic crystal within DNA-responsive hydrogel films, allowing for screening of genetic and epigenetic modifications.

Photonic crystals: A platform for label-free and enhanced fluorescence biomolecular and cellular assays

2008 ◽  
Vol 1133 ◽  
Author(s):  
Brian T. Cunningham ◽  
Leo Chan ◽  
Patrick C. Mathias ◽  
Nikhil Ganesh ◽  
Sherine George ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Photonic Crystals ◽  
High Throughput Screening ◽  
High Sensitivity ◽  
Excitation Wavelength ◽  
Label Free ◽  
Crystal Surfaces ◽  
Enhanced Fluorescence ◽  
Preferred Direction ◽  
Label Free Detection

Abstract Photonic crystal surfaces represent a class of resonant optical structures that are capable of supporting high intensity electromagnetic standing waves with near-field and far-field properties that can be exploited for high sensitivity detection of biomolecules and cells. While modulation of the resonant wavelength of a photonic crystal by the dielectric permittivity of adsorbed biomaterials enables label-free detection, the resonance can also be tuned to coincide with the excitation wavelength of common fluorescent tags - including organic molecules and semiconductor quantum dots. Photonic crystals are also capable of efficiently channeling fluorescent emission into a preferred direction for enhanced extraction efficiency. Photonic crystals can be designed to support multiple resonant modes that can perform label free detection, enhanced fluorescence excitation, and enhanced fluorescence extraction simultaneously on the same device. Because photonic crystal surfaces may be inexpensively produced over large surface areas by nanoreplica molding processes, they can be incorporated into disposable labware for applications such as pharmaceutical high throughput screening. In this talk, the optical properties of surface photonic crystals will be reviewed and several applications will be described, including results from screening a 200,000-member chemical compound library for inhibitors of protein-DNA interactions, gene expression microarrays, and high sensitivity of protein biomarkers.

LSPR-enhanced photonic crystal allows ultrasensitive and label-free detection of hazardous chemicals

2020 ◽  
Vol 310 ◽  
pp. 127671 ◽  
Author(s):  
Yanqiu Song ◽  
Jialei Bai ◽  
Rong Zhang ◽  
Enqi Wu ◽  
Jiang Wang ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Label Free ◽  
Hazardous Chemicals ◽  
Label Free Detection

Label-free optical detection of C-reactive protein by nanoimprint lithography-based 2D-photonic crystal film

2016 ◽  
Vol 11 (6) ◽  
pp. 831-837 ◽  
Author(s):  
Tatsuro Endo ◽  
Hiroshi Kajita ◽  
Yukio Kawaguchi ◽  
Terumasa Kosaka ◽  
Toshiyuki Himi
Keyword(s):  
Photonic Crystal ◽  
Nanoimprint Lithography ◽  
Optical Detection ◽  
Label Free ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Crystal Film

Double-layer Fano resonance photonic-crystal-slab-based sensor for label-free detection of different size analytes

2019 ◽  
Vol 36 (2) ◽  
pp. 215 ◽  
Author(s):  
Zheng Wang ◽  
Chao Wang ◽  
Fujun Sun ◽  
Zhongyuan Fu ◽  
Zekun Xiao ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Double Layer ◽  
Fano Resonance ◽  
Label Free ◽  
Photonic Crystal Slab ◽  
Label Free Detection

scholarly journals Label-free detection of cardiac troponin I with a photonic crystal biosensor

2014 ◽  
Vol 58 ◽  
pp. 107-113 ◽  
Author(s):  
Bailin Zhang ◽  
Andres W. Morales ◽  
Ralph Peterson ◽  
Liang Tang ◽  
Jing Yong Ye
Keyword(s):  
Photonic Crystal ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Label Free ◽  
Label Free Detection
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