A simple and visible colorimetric method through Zr4+–phosphate coordination for the assay of protein tyrosine phosphatase 1B and screening of its inhibitors

The Analyst ◽  
2015 ◽  
Vol 140 (16) ◽  
pp. 5716-5723 ◽  
Author(s):  
Juan Zhang ◽  
Jun Lv ◽  
Xiaonan Wang ◽  
Defeng Li ◽  
Zhaoxia Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Colorimetric Method ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Diabetes And Obesity

Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors.

scholarly journals Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes

Diabetes ◽  
2004 ◽  
Vol 53 (11) ◽  
pp. 3007-3012 ◽  
Author(s):  
J. L. Bento ◽  
N. D. Palmer ◽  
J. C. Mychaleckyj ◽  
L. A. Lange ◽  
C. D. Langefeld ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Protein Tyrosine Phosphatase ◽  
Gene Polymorphisms ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine

scholarly journals Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People

Diabetes ◽  
2005 ◽  
Vol 54 (6) ◽  
pp. 1884-1891 ◽  
Author(s):  
J. C. Florez ◽  
C. M. Agapakis ◽  
N. P. Burtt ◽  
M. Sun ◽  
P. Almgren ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Association Testing

scholarly journals PROTEIN TYROSINE PHOSPHATASE 1B (PTP1B) IN OBESITY AND TYPE 2 DIABETES

2009 ◽  
Vol 38 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Mirela Delibegovic ◽  
Nimesh Mody
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Developed Countries ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
The Developed Countries

Increased incidence in obesity is reaching epidemic proportions and is placing a major burden on the healthcare systems in the developed countries. Obesity is a major risk factor for the development of type 2 diabetes, metabolic syndrome, cardiovascular disease and cancer. Thus, the search for molecules that regulate the development of obesity and its associated pathologies is ongoing. Protein tyrosine phosphatase 1B (PTP1B) has been found to be a major regulator of body fat stores, energy balance, and insulin sensitivity in vivo. Increased expression of PTP1B is associated with insulin resistance in rodents and humans and deletion of PTP1B leads to leanness and insulin sensitivity in rodents, suggesting that PTP1B may be a very attractive molecular target for anti-obesity, anti-diabetic agents.

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