Development of a miniature mass spectrometer with continuous atmospheric pressure interface

The Analyst ◽  
2015 ◽  
Vol 140 (10) ◽  
pp. 3406-3414 ◽  
Author(s):  
Yanbing Zhai ◽  
Yan Feng ◽  
Yongzheng Wei ◽  
Yuzhuo Wang ◽  
Wei Xu
Keyword(s):  
Mass Spectrometer ◽  
Atmospheric Pressure ◽  
Miniature Mass Spectrometer ◽  
Ionization Methods ◽  
Spot Analysis

The demand for on-the-spot analysis is met by a miniature mass spectrometer which is preferred to be robust, stable, as small as possible and capable of analyzing different samples by coupling with various ionization methods.

An aerodynamic assisted miniature mass spectrometer for enhanced volatile sample analysis

The Analyst ◽  
2016 ◽  
Vol 141 (18) ◽  
pp. 5404-5411 ◽  
Author(s):  
Yanbing Zhai ◽  
Ting Jiang ◽  
Guangyan Huang ◽  
Yongzheng Wei ◽  
Wei Xu
Keyword(s):  
Mass Spectrometer ◽  
Atmospheric Pressure ◽  
Detection Sensitivity ◽  
Sample Analysis ◽  
Ionization Source ◽  
Plasma Ionization ◽  
Vacuum Plasma ◽  
Miniature Mass Spectrometer ◽  
Voc Detection

Low ppb-level VOC detection sensitivity was achieved by integrating an in-vacuum plasma ionization source into the continuous atmospheric pressure interfaced miniature mass spectrometer.

scholarly journals Mini 2000: A Robust Miniature Mass Spectrometer with Continuous Atmospheric Pressure Interface

Instruments ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 2 ◽  
Author(s):  
Xiangzhi Meng ◽  
Xiaohua Zhang ◽  
Yanbing Zhai ◽  
Wei Xu
Keyword(s):  
Mass Spectrometer ◽  
Atmospheric Pressure ◽  
Miniature Mass Spectrometer

Atmospheric Pressure Ionization in a Miniature Mass Spectrometer

2005 ◽  
Vol 77 (9) ◽  
pp. 2928-2939 ◽  
Author(s):  
Brian C. Laughlin ◽  
Christopher C. Mulligan ◽  
R. Graham Cooks
Keyword(s):  
Mass Spectrometer ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Ionization ◽  
Miniature Mass Spectrometer

On-Site Diagnosis of Poultry Coccidiosis by a Miniature Mass Spectrometer and Machine Learning

2021 ◽  
Author(s):  
Wei-Chieh Wang ◽  
Hsin-Hsiang Chung ◽  
Ewelina P. Dutkiewicz ◽  
Jhih-Ying Wong ◽  
Wen-Chin Yang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Mass Spectrometer ◽  
Miniature Mass Spectrometer ◽  
Poultry Coccidiosis

scholarly journals Ionization of Volatile Organics and Nonvolatile Biomolecules Directly from a Titanium Slab for Mass Spectrometric Analysis

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6760
Author(s):  
De-Yi Huang ◽  
Meng-Jiy Wang ◽  
Jih-Jen Wu ◽  
Yu-Chie Chen
Keyword(s):  
Mass Spectrometer ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Chemical Ionization ◽  
Metal Substrate ◽  
Ion Source ◽  
Spectrometric Analysis ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical ◽  
High Vapor ◽  
Apci Mass Spectrometry

Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) and electrospray ionization (ESI)-MS can cover the analysis of analytes from low to high polarities. Thus, an ion source that possesses these two ionization functions is useful. Atmospheric surface-assisted ionization (ASAI), which can be used to ionize polar and nonpolar analytes in vapor, liquid, and solid forms, was demonstrated in this study. The ionization of analytes through APCI or ESI was induced from the surface of a metal substrate such as a titanium slab. ASAI is a contactless approach operated at atmospheric pressure. No electric contacts nor any voltages were required to be applied on the metal substrate during ionization. When placing samples with high vapor pressure in condensed phase underneath a titanium slab close to the inlet of the mass spectrometer, analytes can be readily ionized and detected by the mass spectrometer. Furthermore, a sample droplet (~2 μL) containing high-polarity analytes, including polar organics and biomolecules, was ionized using the titanium slab. One titanium slab is sufficient to induce the ionization of analytes occurring in front of a mass spectrometer applied with a high voltage. Moreover, this ionization method can be used to detect high volatile or polar analytes through APCI-like or ESI-like processes, respectively.

scholarly journals Characterisation of the transfer of cluster ions through an atmospheric pressure interface time-of-flight mass spectrometer with hexapole ion guides

2019 ◽  
Vol 12 (10) ◽  
pp. 5231-5246 ◽  
Author(s):  
Markus Leiminger ◽  
Stefan Feil ◽  
Paul Mutschlechner ◽  
Arttu Ylisirniö ◽  
Daniel Gunsch ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Atmospheric Pressure ◽  
Time Of Flight ◽  
Mass Range ◽  
Transmission Efficiency ◽  
Binding Energies ◽  
Cluster Ions ◽  
Ion Transfer ◽  
Flight Mass Spectrometer ◽  
Ion Guides

Abstract. Here we present an alternative approach of an atmospheric pressure interface (APi) time-of-flight mass spectrometer for the study of atmospheric ions and cluster ions, the so-called ioniAPi-TOF. The novelty is the use of two hexapoles as ion guides within the APi. In our case, hexapoles can accept and transmit a broad mass range enabling the study of small precursor ions and heavy cluster ions at the same time. Weakly bound cluster ions can easily de-cluster during ion transfer depending on the voltages applied to the ion transfer optics. With the example system of H3O+(H2O)n=0-3, we estimate that cluster ions with higher binding energies than 17 kcal mol−1 can be transferred through the APi without significant fragmentation, which is considerably lower than about 25 kcal mol−1 estimated from the literature for APi-TOFs with quadrupole ion guides. In contrast to the low-fragmenting ion transfer, the hexapoles can be set to a high-fragmenting declustering mode for collision-induced dissociation (CID) experiments as well. The ion transmission efficiency over a broad mass range was determined to be on the order of 1 %, which is comparable to existing instrumentation. From measurements under well-controlled conditions during the CLOUD experiment, we demonstrate the instrument's performance and present results from an inter-comparison with a quadrupole-based APi-TOF.

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