An iridium oxide microelectrode for monitoring acute local pH changes of endothelial cells

The Analyst ◽  
2015 ◽  
Vol 140 (12) ◽  
pp. 4224-4231 ◽  
Author(s):  
Shu Rui Ng ◽  
Danny O'Hare
Keyword(s):  
Endothelial Cells ◽  
Iridium Oxide ◽  
Ph Changes ◽  
Local Ph ◽  
Stimulation Of

A microelectrode on a chip was modified to detect the local pH changes of the attached endothelial cells under the stimulation of thrombin.

scholarly journals Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

1991 ◽  
Vol 266 (34) ◽  
pp. 23251-23256
Author(s):  
F.J. Oliver ◽  
G. de la Rubia ◽  
E.P. Feener ◽  
M.E. Lee ◽  
M.R. Loeken ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Endothelin 1 ◽  
Stimulation Of

scholarly journals Interleukin-8 and Growth-Regulated Oncogene Alpha Mediate Angiogenesis in Kaposi's Sarcoma

2002 ◽  
Vol 76 (22) ◽  
pp. 11570-11583 ◽  
Author(s):  
Brian R. Lane ◽  
Jianguo Liu ◽  
Paul J. Bock ◽  
Dominique Schols ◽  
Michael J. Coffey ◽  
...  
Keyword(s):  
Cell Culture ◽  
Endothelial Cells ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Interleukin 8 ◽  
Cellular Growth ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Stimulation Of

ABSTRACT The development of the complex neoplasm Kaposi's sarcoma is dependent on infection with the Kaposi's sarcoma-associated herpesvirus (KSHV) and appears to be greatly enhanced by cytokines and human immunodeficiency virus type 1 (HIV-1) Tat. Interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-α) are chemokines involved in chemoattraction, neovascularization, and stimulation of HIV-1 replication. We have previously demonstrated that production of GRO-α is stimulated by exposure of monocyte-derived macrophages (MDM) to HIV-1. Here we show that exposure of MDM to HIV-1, viral Tat, or viral gp120 leads to a substantial increase in IL-8 production. We also demonstrate that IL-8 and GRO-α are induced by KSHV infection of endothelial cells and are crucial to the angiogenic phenotype developed by KSHV-infected endothelial cells in cell culture and upon implantation into SCID mice. Thus, the three known etiological factors in Kaposi's sarcoma pathogenesis—KSHV, HIV-1 Tat, and cellular growth factors—might be linked, in part, through induction of IL-8 and GRO-α.

Evaluation of the role of the DNA surface for enhancing the activity of scaffolded enzymes

2021 ◽  
Vol 57 (32) ◽  
pp. 3925-3928
Author(s):  
Peng Lin ◽  
Huyen Dinh ◽  
Yuki Morita ◽  
Zhengxiao Zhang ◽  
Eiji Nakata ◽  
...  
Keyword(s):  
Ph Changes ◽  
Enhanced Activity ◽  
Local Ph ◽  
Dna Scaffold

Local pH changes on the DNA scaffold surface do not contribute to the enhanced activity of scaffolded enzymes.

Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody

Biomaterials ◽  
2015 ◽  
Vol 51 ◽  
pp. 119-128 ◽  
Author(s):  
Byungtae Hwang ◽  
Sang-Hyun Lee ◽  
Jang-Seong Kim ◽  
Ji Hyun Moon ◽  
In Cheul Jeung ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Receptor Antibody ◽  
Tie2 Receptor ◽  
Stimulation Of
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