Aerosol inhalation exposure study of respiratory toxicity induced by 20 nm anatase titanium dioxide nanoparticles

2014 ◽  
Vol 3 (5) ◽  
pp. 367 ◽  
Author(s):  
Jilei Yin ◽  
Cheng Kang ◽  
Yufeng Li ◽  
Qinnuan Li ◽  
Xiaoyong Zhang ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Inhalation Exposure ◽  
Exposure Study ◽  
Aerosol Inhalation ◽  
20 Nm ◽  
Respiratory Toxicity

scholarly journals Inhalation Exposure Study of Titanium Dioxide Nanoparticles with a Primary Particle Size of 2 to 5 nm

2007 ◽  
Vol 115 (3) ◽  
pp. 397-402 ◽  
Author(s):  
Vicki H. Grassian ◽  
Patrick T. O’Shaughnessy ◽  
Andrea Adamcakova-Dodd ◽  
John M. Pettibone ◽  
Peter S. Thorne
Keyword(s):  
Particle Size ◽  
Titanium Dioxide ◽  
Primary Particle ◽  
Titanium Dioxide Nanoparticles ◽  
Inhalation Exposure ◽  
Primary Particle Size ◽  
Exposure Study

Lung injury study by 15 days inhalation exposure of titanium dioxide nanoparticles in rats

2009 ◽  
Vol 189 ◽  
pp. S186 ◽  
Author(s):  
Kyuhong Lee ◽  
Young-Su Yang ◽  
Soon-Jin Kwon ◽  
Jin-Su Lee ◽  
Seung-Jin Choi ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Lung Injury ◽  
Titanium Dioxide Nanoparticles ◽  
Inhalation Exposure

scholarly journals Synthesis and Characterization of Magnetic Nanomaterials with Adsorptive Properties of Arsenic Ions

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4117
Author(s):  
Agnieszka Wojciechowska ◽  
Zofia Lendzion-Bieluń
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Synthesis Method ◽  
Magnetic Nanomaterials ◽  
Molar Ratio ◽  
Magnetic Adsorbents ◽  
New Synthesis ◽  
Removal Of Arsenic ◽  
20 Nm ◽  
Adsorptive Properties

A new synthesis method of hybrid Fe3O4/C/TiO2 structures was developed using microwave-assisted coprecipitation. The aim of the study was to examine the effect of the addition of glucose and titanium dioxide on adsorptive properties enabling removal of arsenic ions from the solution. The study involved the synthesis of pure magnetite, magnetite modified with glucose and magnetite modified with glucose and titanium dioxide in magnetite: glucose: titanium dioxide molar ratio 1:0.2:3. Materials were characterized by XRD, FT-IR, and BET methods. Magnetite and titanium dioxide nanoparticles were below 20 nm in size in obtained structures. The specific surface area of pure magnetite was approximately 79 m2/g while that of magnetite modified with titanium dioxide was above 190 m2/g. Obtained materials were examined as adsorbents used for removal As(V) ions from aqueous solutions. Adsorption of arsenic ions by pure magnetite and magnetite modified with titanium dioxide was very high, above 90% (initial concentration 10 mg/L), pH in the range from 2 to 7. The preparation of magnetic adsorbents with a high adsorption capacity of As(V) ions was developed (in the range from 19.34 to 11.83 mg/g). Magnetic properties enable the easy separation of an adsorbent from a solution, following adsorption.

Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats

2017 ◽  
Vol 265 ◽  
pp. 61-69 ◽  
Author(s):  
Laurent Gaté ◽  
Clémence Disdier ◽  
Frédéric Cosnier ◽  
François Gagnaire ◽  
Jérôme Devoy ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Inhalation Exposure

scholarly journals Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

2021 ◽  
Author(s):  
Shotaro Yamano ◽  
Tomoki Takeda ◽  
Yuko Goto ◽  
Shigeyuki Hirai ◽  
Yusuke Furukawa ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Inhalation Exposure ◽  
Alternative Methods ◽  
Whole Body ◽  
Dependent Manner ◽  
Exposure Group ◽  
Inhalation Study ◽  
Tio2 Nps ◽  
Rash2 Mice

Background: With the rapid development of alternative methods based on the spirit of animal welfare, the publications of animal studies evaluating endpoints such as cancer have been extremely reduced. There have been no systemic inhalation exposure studies of titanium dioxide nanoparticles (TiO2 NPs) using CByB6F1-Tg(HRAS)2Jic (rasH2) 26-week study mice model for detecting carcinogenicity. Methods: Male and female rasH2 mice were exposed to 2, 8 or 32 mg/m3 of TiO2 NPs for 6 hours/day, 5 days/week for 26 weeks using a whole-body inhalation exposure system, with reference to the Organization for Economic Co-operation and Development principles of Good Laboratory Practice. All tissues including lungs, and blood were collected and subjected to biological and histopathological analyses. Additionally, Ki67 positive index were evaluated in mice lung alveolar epithelial type 2 cell (AEC2). Results: This study established a stable method for generating and exposing TiO2 NPs aerosol, and clarified the dose-response relationship by TiO2 NPs inhalation to rasH2 mice. TiO2 NPs exposure induced deposition of particles in lungs and mediastinal lymph nodes in a dose-dependent manner in each exposure group. Additionally, alveolar inflammation was only observed in 32 mg/m3 exposure group in both the sexes. Exposure to TiO2 NPs, as well as other organs, did not increase the incidence of lung tumors in any group, and pulmonary fibrosis and pre-neoplastic lesions were not observed in all groups. Finally, the cell proliferative activity of AEC2 was examined, and it was not increased by exposure to TiO2 NPs. Conclusions: This is the first report showing the lack of pulmonary fibrogenicity and carcinogenicity (no evidence of carcinogenic activity) of TiO2 NPs in 26-week inhalation study in rasH2 mice exposed up to 32 mg/m3, which is considered to be a high concentration. Macrophages undergoing phagocytosis due to TiO2 NPs exposure formed inflammatory foci in the alveolar regions of exposed mice but did not develop fibrosis or hyperplasia or tumors. Moreover, the cell proliferative ability of AEC2 in lesions was not increased. In addition, no carcinogenicity was observed for any organs other than the lungs in this study.

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