scholarly journals Dual use of porphyrazines as sensitizers and viscosity markers in photodynamic therapy

2015 ◽  
Vol 3 (6) ◽  
pp. 1089-1096 ◽  
Author(s):  
M. Angeles Izquierdo ◽  
Aurimas Vyšniauskas ◽  
Svetlana A. Lermontova ◽  
Ilya S. Grigoryev ◽  
Natalia Y. Shilyagina ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Dual Function ◽  
Dual Use ◽  
Viscosity Measurements ◽  
Therapy Treatment

A dual-function photoactive macrocycle enables simultaneous viscosity measurements and photodynamic therapy treatment, allowing the monitoring of PDT progress by FLIM.

scholarly journals Targeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells

Oncotarget ◽  
2019 ◽  
Vol 10 (58) ◽  
pp. 6079-6095 ◽  
Author(s):  
Channay Naidoo ◽  
Cherie Ann Kruger ◽  
Heidi Abrahamse
Keyword(s):  
Photodynamic Therapy ◽  
Metastatic Melanoma ◽  
Melanoma Cells ◽  
Targeted Photodynamic Therapy ◽  
Therapy Treatment

Molecular geometries and spectra of methyl pyropheophorbide-a pyrazole derivatives: a density functional theory study

2012 ◽  
Vol 16 (02) ◽  
pp. 218-226 ◽  
Author(s):  
Sang Joon Choe ◽  
Young Key Shim ◽  
Oyunbieg Galindev
Keyword(s):  
Density Functional Theory ◽  
Photodynamic Therapy ◽  
Interaction Energy ◽  
Density Functional ◽  
Time Dependent ◽  
Dual Function ◽  
Pyrazole Derivatives ◽  
Excitation Energies ◽  
Functional Theory ◽  
Pyropheophorbide A

Density functional theory (DFT) electronic structure calculations were performed to predict the geometries of the chlorin macrocycle core in methyl pyropheophorbide-a pyrazole derivatives (e.g. HPMPPa and PPMPPa). These compounds are new photosensitizer materials that possess the dual function activity in photodynamic therapy. We found that the geometries of the two compounds were nearly the same, and that substitution of the pyrazole moieties at C31 -position of methyl pyropheophorbide-a did not have significant effects on the geometries of the chlorin macrocycle core. Excitation energies and oscillator strengths were computed by time-dependent DFT. The time-dependent DFT spectrum of HPMPPa and PPMPPa were not affected by the pyrazole substituent. To determine the hydrophilic effect of photosensitizers, we calculated the interaction energy between photosensitizer and water, and observed that the interaction energy of HPMPPa was higher than that of PPMPPa. We found that the interaction energy with specific wavelength (Q-bands) is an important factor to consider in the development of photodynamic therapy.

Photodynamic therapy treatment of superficial fungal infections: A systematic review

2020 ◽  
Vol 31 ◽  
pp. 101774 ◽  
Author(s):  
Julia J. Shen ◽  
Gregor B.E. Jemec ◽  
Maiken C. Arendrup ◽  
Ditte Marie L. Saunte
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Fungal Infections ◽  
Therapy Treatment

Long-term healing of photodynamic therapy: treatment of experimental intimal hyperplasia

1994 ◽  
Author(s):  
Glenn M. LaMuraglia ◽  
N. R. ChandraSekar ◽  
Thomas J. Flotte ◽  
Tayyaba Hasan
Keyword(s):  
Photodynamic Therapy ◽  
Intimal Hyperplasia ◽  
Therapy Treatment
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