The design and synthesis of a soluble composite silica xerogel and the short-time release of proteins

2015 ◽  
Vol 3 (16) ◽  
pp. 3141-3149 ◽  
Author(s):  
Rong Chen ◽  
Haibo Qu ◽  
Shaoyun Guo ◽  
Paul Ducheyne
Keyword(s):  
Controlled Release ◽  
Silica Xerogel ◽  
Large Molecules ◽  
Design And Synthesis ◽  
Short Time

The controlled release of large molecules (such as proteins) in a very short time (several days) was achieved through the co-hydrolysis and co-condensation of different precursors.

Challenges to large molecular encapsulation

2014 ◽  
Vol 86 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Daishi Fujita
Keyword(s):  
Molecular Weight ◽  
Personal Account ◽  
Molecular Encapsulation ◽  
Large Molecules ◽  
Design And Synthesis ◽  
Molecular Cages ◽  
History Of ◽  
Synthetic Scaffold ◽  
One To One ◽  
Synthetic Hosts

Abstract One-to-one capture and confinement of a molecule within a finely designed synthetic scaffold is a highly topical field of research that aims to control the functions, properties, and stabilities of trapped molecules. In this account, a brief history of molecular encapsulation, for the design and synthesis of suitable molecular cages for large molecules, summarizes the daunting synthetic challenge associated with increasing molecular weight, and the attendant challenge to encapsulate macromolecules like proteins by synthetic hosts. Recent approaches toward the overall objective of large molecular encapsulation are discussed, and a personal account is given of the design and assembly of an advanced scaffolding system, which offers the promise of unprecedented progress toward this goal.

scholarly journals Injectable controlled release depots for large molecules

2014 ◽  
Vol 190 ◽  
pp. 240-253 ◽  
Author(s):  
Steven P. Schwendeman ◽  
Ronak B. Shah ◽  
Brittany A. Bailey ◽  
Anna S. Schwendeman
Keyword(s):  
Controlled Release ◽  
Large Molecules

Ultrasound-responsive NIPAM-based hydrogels with tunable profile of controlled release of large molecules

Ultrasonics ◽  
2018 ◽  
Vol 83 ◽  
pp. 157-163 ◽  
Author(s):  
Chueh-Hung Wu ◽  
Ming-Kuan Sun ◽  
Jay Shieh ◽  
Chuin-Shan Chen ◽  
Chang-Wei Huang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Large Molecules

scholarly journals Solution Phase Synthesis of Chemical Libraries for Lead Discovery

1996 ◽  
Vol 1 (4) ◽  
pp. 179-186 ◽  
Author(s):  
Cheryl D. Garr ◽  
John R. Peterson ◽  
Lauri Schultz ◽  
Amy R. Oliver ◽  
Ted L. Underiner ◽  
...  
Keyword(s):  
Analytical Data ◽  
Synthesis Method ◽  
Computational Design ◽  
Significant Degree ◽  
Reaction Products ◽  
Lead Discovery ◽  
Drug Candidates ◽  
Design And Synthesis ◽  
The Individual ◽  
Short Time

By integrating advanced computational design and synthesis, a series of structurally diverse reaction products based on three core scaffolds were prepared by a propietary high throughput synthesis method. Incorporation of auto-mated work stations and sample handling techniques allowed for the production of more than 20,000 compounds in a relatively short time. A method to efficiently obtain quantitative and qualitative analytical data on these compounds was developed. Structural comparison of the individual members of this library with a database of clinical drug candidates revealed a significant degree of similarity based on Tanimoto coefficients.

scholarly journals Periphery Decorated and Core Initiated Neutral and Polyanionic Borane Large Molecules: Forthcoming and Promising Properties for Medicinal Applications

2019 ◽  
Vol 26 (26) ◽  
pp. 5036-5076 ◽  
Author(s):  
Clara Viñas ◽  
Rosario Núñez ◽  
Ines Bennour ◽  
Francesc Teixidor
Keyword(s):  
Self Assembly ◽  
Steric Structure ◽  
Lipid Bilayer Membranes ◽  
Aryl Ether ◽  
Bilayer Membranes ◽  
Boron Clusters ◽  
Large Molecules ◽  
Design And Synthesis ◽  
Novel Applications

A mini-review based on radial growing macromolecules and core initiated Borane periphery decorated with o-carboranes and metallacarboranes that has been developed in the authors laboratories is reported. The review is divided into four sections; three of them are related to the design and synthesis of these large boron-containing molecules and the fourth deals with the unique properties of anionic metallacarborane molecules that provide a glimpse of their potential for their promising use in medicinal applications. Their unique stability along with their geometrical and electronic properties, as well as the precise steric structure of 1,2-closo-C2B10H12 (o-carborane) that has the potential for the incorporation of many substituents: at the carbon (Cc), at the boron and at both carbon and boron vertices, suggests this cluster as an innovative building block or platform for novel applications that cannot be achieved with organic hydrocarbon compounds. Poly(aryl-ether) dendrimers grown from fluorescent cores, such as 1,3,5-triarylbenzene or meso-porphyrins, have been decorated with boron clusters to attain rich boron containing dendrimers. Octasilsesquioxane cubes have been used as a core for its radial growth to get boron-rich large molecules. The unique properties of cobaltabisdicarbollide cluster, which include: i) self-assembly in water to produce monolayer nano-vesicles, ii) crossing lipid bilayer membranes, iii) interacting with membrane cells, iv) facilitating its visualization within cells by Raman and fluorescence techniques and v) their use as molecular platform for “in vivo” imaging are discussed in detail.

Silica xerogel carrier material for controlled release of toremifene citrate

2000 ◽  
Vol 195 (1-2) ◽  
pp. 219-227 ◽  
Author(s):  
Manja Ahola ◽  
Pirjo Kortesuo ◽  
Ilkka Kangasniemi ◽  
Juha Kiesvaara ◽  
Antti Yli-Urpo
Keyword(s):  
Controlled Release ◽  
Silica Xerogel ◽  
Carrier Material
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