Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (8) ◽  
pp. 1712-1721 ◽  
Author(s):  
Lin Xiong ◽  
Xin Du ◽  
Bingyang Shi ◽  
Jingxiu Bi ◽  
Freddy Kleitz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Label Free ◽  
Ethylene Imine ◽  
Intracellular Drug Delivery ◽  
Poly Ethylene

Tunable stellate mesoporous silica nanoparticles are functionalized with low molecular poly(ethylene imine) for efficient label-free intracellular drug delivery.

scholarly journals Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 237 ◽  
Author(s):  
Diti Desai ◽  
Malin Åkerfelt ◽  
Neeraj Prabhakar ◽  
Mervi Toriseva ◽  
Tuomas Näreoja ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Surface Charge ◽  
Silica Nanoparticles ◽  
Lipid Bilayers ◽  
Mesoporous Silica Nanoparticles ◽  
Cellular Level ◽  
Dependent Manner ◽  
Ethylene Imine ◽  
Intracellular Drug Delivery

Intracellular drug delivery by mesoporous silica nanoparticles (MSNs) carrying hydrophilic and hydrophobic fluorophores as model drug cargo is demonstrated on 2D cellular and 3D tumor organoid level. Two different MSN designs, chosen on the basis of the characteristics of the loaded cargo, were used: MSNs with a surface-grown poly(ethylene imine), PEI, coating only for hydrophobic cargo and MSNs with lipid bilayers covalently coupled to the PEI layer as a diffusion barrier for hydrophilic cargo. First, the effect of hydrophobicity corresponding to loading degree (hydrophobic cargo) as well as surface charge (hydrophilic cargo) on intracellular drug release was studied on the cellular level. All incorporated agents were able to release to varying degrees from the endosomes into the cytoplasm in a loading degree (hydrophobic) or surface charge (hydrophilic) dependent manner as detected by live cell imaging. When administered to organotypic 3D tumor models, the hydrophilic versus hydrophobic cargo-carrying MSNs showed remarkable differences in labeling efficiency, which in this case also corresponds to drug delivery efficacy in 3D. The obtained results could thus indicate design aspects to be taken into account for the development of efficacious intracellular drug delivery systems, especially in the translation from standard 2D culture to more biologically relevant organotypic 3D cultures.

scholarly journals Label-Free Luminescent Mesoporous Silica Nanoparticles for Imaging and Drug Delivery

Theranostics ◽  
2013 ◽  
Vol 3 (9) ◽  
pp. 650-657 ◽  
Author(s):  
Hongmin Chen ◽  
Zipeng Zhen ◽  
Wei Tang ◽  
Trever Todd ◽  
Yen-Jun Chuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Label Free

Bifunctional Succinylated ε-Polylysine-Coated Mesoporous Silica Nanoparticles for pH-Responsive and Intracellular Drug Delivery Targeting the Colon

2017 ◽  
Vol 9 (11) ◽  
pp. 9470-9483 ◽  
Author(s):  
Chau T. H. Nguyen ◽  
Richard I. Webb ◽  
Lynette K. Lambert ◽  
Ekaterina Strounina ◽  
Edward C. Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

scholarly journals Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

2017 ◽  
Vol 5 (48) ◽  
pp. 9497-9501 ◽  
Author(s):  
Mingyang Hei ◽  
Jun Wang ◽  
Kelly Wang ◽  
Weiping Zhu ◽  
Peter X. Ma
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Disulfide Bonds ◽  
Mesoporous Silica Nanoparticles ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Dual Responsive ◽  
Intracellular Drug Delivery ◽  
Upper Critical Solution Temperature

A novel, dual responsive and intracellular delivery system was developed by grafting UCST-type polymers onto the surface of mesoporous silica nanoparticles through disulfide bonds.

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