Surface modified titania nanotubes containing anti-bacterial drugs for controlled delivery nanosystems with high bioactivity

2014 ◽  
Vol 2 (48) ◽  
pp. 8616-8625 ◽  
Author(s):  
Peilin Huang ◽  
Jingnan Wang ◽  
Shuting Lai ◽  
Fang Liu ◽  
Nan Ni ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Controlled Delivery ◽  
Titania Nanotubes ◽  
Surface Modified

Drug delivery nanosystems have been designed as Enro-NH2-TNTs and Enro-SH-TNTs with high bioactivity and excellent in vitro and in vivo controlled release.

Bio-Resorbable Nanoceramics for Gene and Drug Delivery

MRS Bulletin ◽  
2004 ◽  
Vol 29 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Waltraud M. Kriven ◽  
Seo-Young Kwak ◽  
Matthew A. Wallig ◽  
Jin-Ho Choy
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Negative Charge ◽  
Acidic Environment ◽  
Biological Cells ◽  
Double Hydroxides ◽  
Or Genes

AbstractNanoscale ceramic particles, such as layered double hydroxides (LDHs), have been developed to deliver drugs or genes into biological cells. In this article, we describe the controlled-release properties of LDHs as drug delivery carriers, the formation of bio-LDH nanohybrids, theirin vivoandin vitrocytotoxicity tests, and their potential as anticancer gene delivery carriers. Unstable biomolecules can be intercalated into LDHs, displacing the interlayer anions; the drug or gene's negative charge is thus shielded, enabling penetration into the cell. In the slightly acidic environment of the cell, ceramic nanoplatelets of ∼100 nm diameter dissolve, thus releasing the intercalates in a controlled manner.

scholarly journals PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery

2019 ◽  
Author(s):  
Meishan Chen ◽  
Xiangru Feng ◽  
Weiguo Xu ◽  
Yanqiao Wang ◽  
Yanan Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Delivery ◽  
Tert Butyl ◽  
Chemical Structures ◽  
Biomedical Polymers ◽  
Poly Ethylene ◽  
4T1 Cells ◽  
Chemical Groups

In recent years, polyureas with dynamic hindered urea bonds (HUBs), as a class of promising biomedical polymers, have attracted attention as a benefit of their controlled hydrolytic property. The effect of the chemical structures on the properties of polyureas and their assemblies was rarely reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyurea from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. The amphiphilic polyurea composed of hydrophobic cyclohexyl-tert-butyl polyurea and hydrophilic poly(ethylene glycol) was synthesized for controlled delivery of antitumor drug paclitaxel (PTX). The PTX-loaded PEGylated polyurea micelle more effectively entered into the murine breast cancer 4T1 cells and inhibited the corresponding tumor growth in vitro and in vivo. Therefore, the PEGylated polyurea with adjustable degradation might be a promising polymer matrix for drug delivery.

Latest advances in hydrogel-based drug delivery systems for optimization of metabolic syndrome treatment

2021 ◽  
Vol 28 ◽  
Author(s):  
Diego Arauna ◽  
Sekar Vijayakumar ◽  
Esteban Durán-Lara
Keyword(s):  
Drug Delivery ◽  
Metabolic Syndrome ◽  
Controlled Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Epigallocatechin Gallate ◽  
Delivery Systems ◽  
The Metabolic Syndrome

Background: Drug delivery systems such as hydrogels have become relevant in cardiovascular and metabolic therapies due to their sustained and controlled release properties of drugs, versatile polymer structures, safety and biodegradability. Results: The literature presented demonstrates that a hydrogel-based controlled release system increases the therapeutic efficacy in different components of the metabolic syndrome. Hypertension has been the most explored component with advances in vitro and murine models. However, clinical evidence in humans is scarce, and more translational studies are needed. Hydrogel-based systems for diabetes, obesity, and dyslipidemia have been little explored. Observations mainly demonstrated an increase in therapeutic efficacy, in vitro and in vivo, for the use of insulin, leptin, and natural components, such as epigallocatechin gallate. In all cases, the hydrogel systems achieve better plasma levels of the loaded compound, higher bioavailability, and low cytotoxicity; compared to conventional systems. Also, the evidence existing suggests that the development of an injectable hydrogel system for controlled release of drugs or therapeutic compounds is presented as an attractive option for MeS treatment, due to the possibility of sustained pharmacological release, no need for repeated doses, and a safe administration route. Conclusion: The following review aims to evaluate the use of the hydrogel systems in the therapy of diabetes, obesity, hypertension, and dyslipidemia, which are the main components of metabolic syndrome.

scholarly journals Evaluation of Metformin Hydrochloride Floating Drug Delivery System: In vitro Study and In vivo Prediction

2021 ◽  
pp. 143-155
Author(s):  
Rajesh Pawar ◽  
Swati Jagdale
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Dosage Form ◽  
Metformin Hydrochloride ◽  
Test Product ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System ◽  
Controlled Release Tablets

Aim: This research work was aimed to evaluate Metformin hydrochloride (MH) floating dosage form by In vitro evaluation/In vivo prediction and to evaluate it’s predictability through it’s application during the R&D using Insilico technique in WINONLIN Software. MH was examined as a model drug, which is a biguanide and is an hypoglycemic agent administered orally. The study was aimed to determine the the systemic concentrations of MH using In-vivo prediction. Study Design: Fabrication and assessment of Metformin hydrochloride floating drug delivery system: In Vitro evaluation /In Vivo prediction. Biorelevant media was selected for dissolution profile of 12 units of dosage form. Software assisted program used for data feeding and results output. Methodology: The absorption window for MH is the upper portion of the small gut in which the GI absorption is complete after 6 h. Hence gastroretentive formulation was developed and validity of dissolution study was extended by In vivo pharmacokinetic prediction using WinNonlin Software. A mechanistic oral absorption model was built in Phoenix WinNonlin® software. In the presented work, significant yet crucial, gastrointestinal (GI) variables are considered for biopredictive dissolution testing to account for a valuable input for physiologically-based pharmacokinetic (PBPK) platform programs. While simulations are performed and mechanistic insights are gained from such simulations from the WinNonlin program. Results: These floating tablets were observed for In vitro release and studied for In vivo pharmacokinetic prediction. From the obtained values, a meaningful In vivo prediction was done. interestingly from the results attained floating tablets showed sustained drug release and extended drug absorbed in 24h. Fascinatingly, from the data it was proved that drug formulation resides for desired time. The absorption of MH from the developed CR tablet was 1.4 fold higher than its marketed tablet and it had higher AUC0–t values than the marketed product which indicates superior bioavailability of test product compared to marketed tablet with similar dose in Invivo pharmacokinetic prediction. The mean value of biological half-life (t1/2) and Tmax of MH from test formulation is two times more, Test product has shown higher MRT, showing that the drug is maintained longer in the body in comparison to marketed product indicates controlled absorption. Conclusion: Here we concluded that, a comparative prediction pharmacokinetic evaluation of the fabricated controlled release tablets and the marketed formulation indicates that the fabricated controlled release tablets are well absorbed and the degree of absorption is greater than that of the marketed ER formulation with larger gastric residence time.

scholarly journals PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1538 ◽  
Author(s):  
Chen ◽  
Feng ◽  
Xu ◽  
Wang ◽  
Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Delivery ◽  
Tert Butyl ◽  
Chemical Structures ◽  
Biomedical Polymers ◽  
Poly Ethylene ◽  
4T1 Cells ◽  
Chemical Groups

In recent years, polyureas with dynamic hindered urea bonds (HUBs), a class of promising biomedical polymers, have attracted wide attention as a result of their controlled hydrolytic properties. The effect of the chemical structures on the properties of polyureas and their assemblies has rarely been reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyureas from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. The amphiphilic polyurea composed of hydrophobic cyclohexyl-tert-butyl polyurea and hydrophilic poly(ethylene glycol) (PEG) was synthesized for the controlled delivery of the antitumor drug paclitaxel (PTX). The PTX-loaded PEGylated polyurea micelle more effectively entered into the murine breast cancer 4T1 cells and inhibited the corresponding tumor growth in vitro and in vivo. Therefore, the PEGylated polyurea with adjustable degradation might be a promising polymer matrix for drug delivery.

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