Dendrimer-functionalized electrospun cellulose acetate nanofibers for targeted cancer cell capture applications

2014 ◽  
Vol 2 (42) ◽  
pp. 7384-7393 ◽  
Author(s):  
Yili Zhao ◽  
Xiaoyue Zhu ◽  
Hui Liu ◽  
Yu Luo ◽  
Shige Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Cellulose Acetate ◽  
Cancer Cell ◽  
Cell Capture

Multifunctional folic acid-functionalized dendrimers can be modified on the surface of electrospun cellulose acetate nanofibers for the specific capture of FAR-overexpressing cancer cells.

scholarly journals Folic acid modified electrospun poly(vinyl alcohol)/polyethyleneimine nanofibers for cancer cell capture applications

2016 ◽  
Vol 34 (6) ◽  
pp. 755-765 ◽  
Author(s):  
Zhang-yu Fan ◽  
Yi-li Zhao ◽  
Xiao-yue Zhu ◽  
Yu Luo ◽  
Ming-wu Shen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cell ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Cell Capture

Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip for cancer cell capture and culture

2017 ◽  
Vol 5 (4) ◽  
pp. 752-761 ◽  
Author(s):  
Gangwei Xu ◽  
Yulong Tan ◽  
Tiegang Xu ◽  
Di Yin ◽  
Mengyuan Wang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Microfluidic Chip ◽  
Cell Capture

Hyaluronic acid-functionalized electrospun PLGA nanofibers embedded in a microfluidic chip are able to effectively capture cancer cells.

Coordination-driven reversible surfaces with site-specifically immobilized nanobody for dynamic cancer cell capture and release

2020 ◽  
Vol 8 (33) ◽  
pp. 7511-7520
Author(s):  
Lulu Han ◽  
Ruilian Peng ◽  
Wenning Jiang ◽  
Ting Xu ◽  
Chong Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
High Efficiency ◽  
Cell Capture ◽  
Capture And Release

Coordination-driven reversible surfaces with site-specifically immobilized his-tagged nanobody for high-efficiency capture and release of cancer cells.

Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells

2004 ◽  
Vol 287 (3) ◽  
pp. G541-G546 ◽  
Author(s):  
Kiran K. Nagothu ◽  
Arun K. Rishi ◽  
Richard Jaszewski ◽  
Omer Kucuk ◽  
Adhip P. N. Majumdar
Keyword(s):  
Colon Cancer ◽  
Folic Acid ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Promoter Activity ◽  
Colon Cancer Cell ◽  
Luciferase Reporter ◽  
Colon Cancer Cells ◽  
Hct 116 ◽  
Stimulation Of

Although accumulating evidence suggests a chemopreventive role for folic acid (FA) in colorectal carcinogenesis, the underlying mechanisms are largely unknown. Previously, we reported that supplemental FA inhibits the expression and activation of epidermal growth factor receptor (EGFR) in colon cancer cell lines. To determine the mechanism(s) by which FA affects EGFR function, we have examined whether and to what extent supplemental FA or its metabolites 5-methyltetrahydrofolate (MTF), dihydrofolate (DF), and tetrahydrofolate (TF) will modulate basal and serum-induced activation of the EGFR promoter in the HCT-116 colon cancer cell line. HCT-116 cells were preincubated with or without (control) FA or one of its metabolites (10 μg/ml) for 48 h, transfected with the EGFR promoter luciferase reporter construct, and incubated for 48 h with FA, DF, TF, or 5-MTF in the absence or presence of 10% FBS. Supplemental FA as well as its metabolites markedly inhibited EGFR promoter activity and its methylation status. Exposure of the cells to 10% FBS caused a marked stimulation of EGFR promoter activity and its expression, both of which were greatly abrogated by supplemental FA and 5-MTF. In contrast, serum-induced activation of c- fos promoter activity was unaffected by 5-MTF. The 5-MTF-induced inhibition of serum-mediated stimulation of EGFR promoter activity and EGFR expression was reversed when methylation was inhibited by 5-aza-2′-deoxycytidine. Our data suggest that FA and its metabolite 5-MTF inhibit EGFR promoter activity in colon cancer cells by enhancing methylation. This could partly be responsible for FA-mediated inhibition of growth-related processes in colorectal neoplasia.

MICROFLUIDIC CHIP FOR CANCER CELL DETECTION AND DIAGNOSIS

2018 ◽  
Vol 18 (01) ◽  
pp. 1830001 ◽  
Author(s):  
CHIYU LI ◽  
WANG LI ◽  
CHUNYANG GENG ◽  
HAIJUN REN ◽  
XIAOHUI YU ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Microfluidic Chip ◽  
Cell Biology ◽  
Cell Detection ◽  
Microfluidic Chips ◽  
Cell Capture ◽  
Unique Method ◽  
Detection And Diagnosis ◽  
Cancer Cell Detection

Since cancer becomes the most deadly disease to our health, research on early detection on cancer cells is necessary for clinical treatment. The combination of microfluidic device with cell biology has shown a unique method for cancer cell research. In the present review, recent development on microfluidic chip for cancer cell detection and diagnosis will be addressed. Some typical microfluidic chips focussed on cancer cells and their advantages for different kinds of cancer cell detection and diagnosis will be listed, and the cell capture methods within the microfluidics will be simultaneously mentioned. Then the potential direction of microfluidic chip on cancer cell detection and diagnosis in the future is also discussed.

Cancer cell–nanomaterial interface: role of geometry and surface charge of nanocomposites in the capture efficiency and cell viability

2019 ◽  
Vol 7 (7) ◽  
pp. 2759-2768 ◽  
Author(s):  
Yishu He ◽  
Jingwen Qin ◽  
Shengming Wu ◽  
Haocheng Yang ◽  
Huiyun Wen ◽  
...  
Keyword(s):  
Cell Viability ◽  
Surface Charge ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Capture Efficiency ◽  
Experimental Results ◽  
Magnetic Nanocomposites ◽  
Cell Capture ◽  
Cell Interface

The nanomaterial–cell interface plays an important role in biodetection and therapy. The experimental results in this study indicated that the magnetic nanocomposites with strong positive surface charge but different geometry interacted with cancer cells in different ways, leading to various cell capture efficiency and cytotoxicity.

Cancer Cell Surface Negative Charges: A Bio-Physical Manifestation of the Warburg Effect

Nano LIFE ◽  
2017 ◽  
Vol 07 (03n04) ◽  
pp. 1771001 ◽  
Author(s):  
Donglu Shi
Keyword(s):  
Early Detection ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Cell ◽  
Cell Detection ◽  
Cell Capture ◽  
Metabolic Pattern ◽  
Early Cancer Diagnosis ◽  
Highly Sensitive

The early detection of circulating tumor cells (CTCs) in blood as part of medical diagnosis will give the doctors a head start in the provision and treatment of cancer, and therefore, with the advance in Nano technology, there is an increasing expectation of some form of early detection of circulating tumor cells at a highly sensitive level, without any biomarkers, for both early cancer diagnosis and monitoring disease progression after medical intervention. This technical note reports on the recent development in detection of highly sensitive detection of cancer cells without biomarkers. This novel concept is developed based on a hallmark cancer metabolic pattern: high glycolysis rate. Secretion of high level of lactate acid by cancer cells ultimately results in negative electrical charges on their surfaces, enabling strong binding and capturing by the positively-charged nanoprobes, and subsequent magnetic separation. When nanoprobes are incubated with cancer cells in suspension, binding takes place due to charge differences, and cancer cells are then magnetically separated. The separated cells are enumerated using a flow cytometry and identified by pathological and genome sequencing methods. Preliminary results using the approach have shown exceptionally high cancer cell capture rates, therefore potentially applicable in cancer cell detection in clinical settings.

PEI–folic acid modified carbon nanodots for cancer cell-targeted delivery and two-photon excitation imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 19662-19668 ◽  
Author(s):  
Jing Wang ◽  
Jun Liu
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Targeted Delivery ◽  
Carbon Nanodots ◽  
Two Photon ◽  
Photon Excitation ◽  
Binding Capability ◽  
Coated Carbon ◽  
Target Cancer

PET–folic acid coated carbon nanodots (CDots) as the targeting fluorescence imaging probe agents. Folic acid (FA) was used as the targeting ligand to enhance the CDots' binding capability and penetration into the target cancer cells.

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