scholarly journals Cellular uptake of ribonuclease A-functionalised core–shell silica microspheres

2014 ◽  
Vol 2 (42) ◽  
pp. 7307-7315 ◽  
Author(s):  
G. F. Chimonides ◽  
J. M. Behrendt ◽  
E. Chundoo ◽  
C. Bland ◽  
A. V. Hine ◽  
...  
Keyword(s):  
Cell Viability ◽  
Cellular Uptake ◽  
Ribonuclease A ◽  
Core Shell ◽  
Protein Transduction ◽  
Silica Microspheres ◽  
P Protein

Protein transduction: core–shell microspheres have been synthesised and coupled to ribonuclease A. Cellular uptake of these microspheres causes significantly reduced levels of intracellular RNA and reduced cell viability demonstrating that core–shell microsphere-mediated delivery of active enzymes into cells is effective.

Probing Cellular Outcomes Using Heterobivalent Constructs

2019 ◽  
Author(s):  
Rohit Bhadoria ◽  
Kefeng Ping ◽  
Christer Lohk ◽  
Ivar Järving ◽  
Pavel Starkov
Keyword(s):  
Cell Viability ◽  
Small Molecules ◽  
Cellular Uptake ◽  
Kinase Inhibitors ◽  
Rho Kinase ◽  
Intracellular Delivery ◽  
Rho Kinase Inhibitors

<div> <div> <div> <p>Conjugation techniques are central to improving intracellular delivery of bioactive small molecules. However, tracking and assessing the overall biological outcome of these constructs remains poorly understood. We addressed this issue by having developed a focused library of heterobivalent constructs based on Rho kinase inhibitors to probe various scenarios. By comparing induction of a phenotype of interest vs. cell viability vs. cellular uptake, we demonstrate that such conjugates indeed lead to divergent cellular outcomes. </p> </div> </div> </div>

Multifunctional core-shell silica microspheres and their performance in self-carrier decomposition, sustained drug release and fluorescent bioimaging

2018 ◽  
Vol 263 ◽  
pp. 148-156 ◽  
Author(s):  
Yamina Ait Mehdi ◽  
Asma Itatahine ◽  
Meriem Fizir ◽  
Deli Xiao ◽  
Pierre Dramou ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Silica Microspheres ◽  
Sustained Drug Release

Cell viability assessments of green synthesized water-soluble AgInS2/ZnS core/shell quantum dots against different cancer cell lines

2019 ◽  
Vol 34 (24) ◽  
pp. 4037-4044 ◽  
Author(s):  
Oluwatobi S. Oluwafemi ◽  
Bambesiwe M.M. May ◽  
Sundararajan Parani ◽  
Jose Varghese Rajendran
Keyword(s):  
Quantum Dots ◽  
Cell Viability ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Water Soluble ◽  
Core Shell ◽  
Image Position

Abstract

A phenotypic approach to probing cellular outcomes using heterobivalent constructs

2020 ◽  
Vol 56 (30) ◽  
pp. 4216-4219
Author(s):  
Rohit Bhadoria ◽  
Kefeng Ping ◽  
Christer Lohk ◽  
Ivar Järving ◽  
Pavel Starkov
Keyword(s):  
Cell Viability ◽  
Cellular Uptake

By comparing the induction of the phenotype of interest, cell viability and cellular uptake, we demonstrate that various conjugates lead to divergent cellular outcomes.

Cellular uptake, cytotoxicity, and ROS generation with silica/conducting polymer core/shell nanospheres

Biomaterials ◽  
2011 ◽  
Vol 32 (29) ◽  
pp. 7217-7225 ◽  
Author(s):  
Yoon Seon Jeong ◽  
Wan-Kyu Oh ◽  
Sojin Kim ◽  
Jyongsik Jang
Keyword(s):  
Conducting Polymer ◽  
Cellular Uptake ◽  
Ros Generation ◽  
Core Shell
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